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公开(公告)号：US20160103058A1
公开(公告)日：2016-04-14
申请号：US14893780
申请日：2014-05-28
Applicant: CHEMOMETEC A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
CPC classification number: G01N15/1434 , G01N2015/0065 , G01N2015/1006 , G01N2015/1438 , G01N2015/144 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024
Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).
Abstract translation: 本发明涉及通常在低光学放大下进行图像细胞分析的方法和系统，其中分析基于使用UV亮场，暗场或一个或多个激发光源的生物颗粒的检测。 该系统包括照明装置（11,112），样品保持器（100），样本室（101），成像装置（120），收集装置（121），光调制装置（122,123）和检测装置 130）具有主动检测元件（131）。
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公开(公告)号：US20180195958A1
公开(公告)日：2018-07-12
申请号：US15879696
申请日：2018-01-25
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US10254223B2
公开(公告)日：2019-04-09
申请号：US15879696
申请日：2018-01-25
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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Patent Agency Ranking
公开(公告)号：US09903819B2
公开(公告)日：2018-02-27
申请号：US14473020
申请日：2014-08-29
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
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公开(公告)号：US20150053872A1
公开(公告)日：2015-02-26
申请号：US14473020
申请日：2014-08-29
Applicant: ChemoMetec A/S
Inventor： Søren Kjaerulff , Mette Elena Skinderso , Helle Frobose Sorensen , Frans Ejner Ravn , Martin Glensbjerg
IPC: G01N21/64
CPC classification number: G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478 , G01N2201/0631 , G02B27/0905 , G02B27/0961
Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.
Abstract translation: 根据本发明的实施例，公开了一种从样品中检测荧光的装置。 所述装置包括：样品布置在其上的样品平面，至少包括用于照射样品的光源的激发光单元;以及检测单元，其至少包括具有至少100,000个活性检测元件的检测器，以检测来自 例子。
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公开(公告)号：US20160131658A1
公开(公告)日：2016-05-12
申请号：US14821096
申请日：2015-08-07
Applicant: ChemoMetec A/S
Inventor： Mette Elena Skindersø , Helle Frøbose Sørensen , Søren Kjaerulff
CPC classification number: G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
Abstract translation: 本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。 本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途） 。 本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。 此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。 本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。
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公开(公告)号：US10458896B2
公开(公告)日：2019-10-29
申请号：US14893780
申请日：2014-05-28
Applicant: ChemoMetec A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).
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公开(公告)号：US20170261419A1
公开(公告)日：2017-09-14
申请号：US15532216
申请日：2015-12-03
Applicant: ChemoMetec A/S
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, in particular using light sources to be cooled. Thereby is provided optimal light conditions for image cytometry.
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