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公开(公告)号：US20120238569A1
公开(公告)日：2012-09-20
申请号：US13399106
申请日：2012-02-17
Applicant: Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar
IPC: A61K31/5377 , C07D417/12 , C07D417/14 , C07D409/12 , C07D409/14 , A61P11/06 , A61K31/427 , A61K31/381 , A61K31/416 , A61K31/506 , A61K31/497 , A61P11/00 , C07D277/56 , A61K31/426
CPC classification number: C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：US07115740B2
公开(公告)日：2006-10-03
申请号：US10817697
申请日：2004-04-02
Applicant: Yi Chen , Apostolos Dermatakis , Jin-Jun Liu , Kin-Chun Luk , Christophe Michoud , Pamela Loreen Rossman
Inventor： Yi Chen , Apostolos Dermatakis , Jin-Jun Liu , Kin-Chun Luk , Christophe Michoud , Pamela Loreen Rossman
IPC: C07D487/04 , C07D239/47 , C07D407/12 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04
Abstract: Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.
Abstract translation: 公开了作为KDR和FGFR激酶的选择性抑制剂的新型嘧啶化合物。 这些化合物及其药学上可接受的盐是可用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物和治疗癌症的方法。
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公开(公告)号：US20060063804A1
公开(公告)日：2006-03-23
申请号：US11224175
申请日：2005-09-12
Applicant: Li Chen , Shaoqing Chen , Christophe Michoud
Inventor： Li Chen , Shaoqing Chen , Christophe Michoud
IPC: A61K31/4709 , C07D417/02
CPC classification number: C07D521/00 , C07D417/06 , C07D417/14
Abstract: Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.
Abstract translation: 噻唑啉酮取代的喹啉衍生物，其中喹啉环在2位被取代，该衍生物表现出CDK1抗增殖活性并且可用作抗癌剂。
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公开(公告)号：US20060258740A1
公开(公告)日：2006-11-16
申请号：US11429137
申请日：2006-05-05
Applicant: Christophe Michoud
Inventor： Christophe Michoud
IPC: A61K31/325 , C07C271/24
CPC classification number: C07C243/38 , C07C255/57 , C07C2601/04 , C07C2601/08 , C07C2603/18 , C07D213/86 , C07D307/68 , C07D307/84 , C07D307/85 , C07D333/38
Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
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公开(公告)号：US20060178532A1
公开(公告)日：2006-08-10
申请号：US11343567
申请日：2006-01-31
Applicant: David Bolin , Christophe Michoud
Inventor： David Bolin , Christophe Michoud
IPC: C07C241/02
CPC classification number: C07D335/02 , C07C259/08 , C07C259/10 , C07C317/22 , C07C323/18 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07D307/68 , C07D309/08 , C07D333/38
Abstract: Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Abstract translation: 本文提供了式（1）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。
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Patent Agency Ranking
公开(公告)号：US06221867B1
公开(公告)日：2001-04-24
申请号：US09464534
申请日：1999-12-15
Applicant: Kin-Chun Luk , Christophe Michoud
Inventor： Kin-Chun Luk , Christophe Michoud
IPC: C07D24136
CPC classification number: C07D487/04
Abstract: Disclosed are novel 4,5-pyrazinoxindoles having the formula These compounds inhibit or modulate protein kinases, in particular JNK protein kinases. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are useful as anti-inflammatory agents, particularly useful in the treatment of rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing such compounds, and methods for the treatment and/or control of inflammation, particularly in the treatment or control of rheumatoid arthritis, using these compounds.
Abstract translation: 公开了具有下式的新的4,5-吡嗪氧吲哚：这些化合物抑制或调节蛋白激酶，特别是JNK蛋白激酶。 这些化合物及其药学上可接受的盐和所述化合物的前药可用作抗炎剂，特别可用于治疗类风湿性关节炎。 还公开了含有这些化合物的药物组合物，以及使用这些化合物治疗和/或控制炎症，特别是治疗或控制类风湿性关节炎的方法。
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公开(公告)号：US20120270875A1
公开(公告)日：2012-10-25
申请号：US13399117
申请日：2012-02-17
Applicant: Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
Inventor： Paul Gillespie , Christophe Michoud , Kenneth Carey Rupert , Kshitij Chhabilbhai Thakkar , Lin Yi
IPC: A61K31/5377 , A61K31/506 , C07D413/14 , C07D409/14 , C07D239/42 , C07D409/12 , C07D401/12 , C07D417/14 , A61P11/06 , A61P11/00 , A61K31/505 , A61K31/497 , C07D403/12
CPC classification number: C07D239/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。
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公开(公告)号：US20080146565A1
公开(公告)日：2008-06-19
申请号：US12001021
申请日：2007-12-07
Applicant: James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
Inventor： James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
IPC: A61K31/506 , A61P29/00 , C07D413/04 , A61K31/5377 , C07D413/14 , C07D471/04 , C07D403/04
CPC classification number: C07D403/04 , C07D471/04 , C07D487/04
Abstract: Compounds of formula I modulate JNK: wherein the variables are as defined herein.
Abstract translation: 式I的化合物调节JNK：其中变量如本文所定义。
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公开(公告)号：US20080103142A1
公开(公告)日：2008-05-01
申请号：US11899758
申请日：2007-09-07
Applicant: David Goldstein , Leyi Gong , Christophe Michoud , Wylie Palmer , Achyutharao Sidduri
Inventor： David Goldstein , Leyi Gong , Christophe Michoud , Wylie Palmer , Achyutharao Sidduri
IPC: A61K31/5377 , A61K31/506 , A61P19/02 , A61P25/16 , A61P25/28 , A61P3/10 , C07D403/04 , C07D413/14
CPC classification number: C07D403/04 , C07D403/14
Abstract: Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.
Abstract translation: 式I的化合物调节jnk和cdk：或其药学上可接受的盐，其中R 1，R 1，R 2，R 3，和 m在本文中定义。
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公开(公告)号：US07241893B2
公开(公告)日：2007-07-10
申请号：US11224175
申请日：2005-09-12
Applicant: Li Chen , Shaoqing Chen , Christophe Michoud
Inventor： Li Chen , Shaoqing Chen , Christophe Michoud
IPC: C07D221/02
CPC classification number: C07D521/00 , C07D417/06 , C07D417/14
Abstract: Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.
Abstract translation: 噻唑啉酮取代的喹啉衍生物，其中喹啉环在2位被取代，该衍生物表现出CDK1抗增殖活性并且可用作抗癌剂。
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