公开(公告)号：US20120238569A1

公开(公告)日：2012-09-20

申请号：US13399106

申请日：2012-02-17

Applicant: Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

Inventor： Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

IPC: A61K31/5377 ,  C07D417/12 ,  C07D417/14 ,  C07D409/12 ,  C07D409/14 ,  A61P11/06 ,  A61K31/427 ,  A61K31/381 ,  A61K31/416 ,  A61K31/506 ,  A61K31/497 ,  A61P11/00 ,  C07D277/56 ,  A61K31/426

CPC classification number: C07D277/20 ,  C07D333/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。

公开(公告)号：US07115740B2

公开(公告)日：2006-10-03

申请号：US10817697

申请日：2004-04-02

Applicant: Yi Chen ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk ,  Christophe Michoud ,  Pamela Loreen Rossman

Inventor： Yi Chen ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk ,  Christophe Michoud ,  Pamela Loreen Rossman

IPC: C07D487/04 ,  C07D239/47 ,  C07D407/12 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.

Abstract translation: 公开了作为KDR和FGFR激酶的选择性抑制剂的新型嘧啶化合物。 这些化合物及其药学上可接受的盐是可用于治疗或控制实体瘤，特别是乳腺癌，结肠癌，肺癌和前列腺肿瘤的抗增殖剂。 还公开了含有这些化合物的药物组合物和治疗癌症的方法。

公开(公告)号：US20060063804A1

公开(公告)日：2006-03-23

申请号：US11224175

申请日：2005-09-12

Applicant: Li Chen ,  Shaoqing Chen ,  Christophe Michoud

Inventor： Li Chen ,  Shaoqing Chen ,  Christophe Michoud

IPC: A61K31/4709 ,  C07D417/02

CPC classification number: C07D521/00 ,  C07D417/06 ,  C07D417/14

Abstract: Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.

Abstract translation: 噻唑啉酮取代的喹啉衍生物，其中喹啉环在2位被取代，该衍生物表现出CDK1抗增殖活性并且可用作抗癌剂。

公开(公告)号：US20060258740A1

公开(公告)日：2006-11-16

申请号：US11429137

申请日：2006-05-05

Applicant: Christophe Michoud

Inventor： Christophe Michoud

IPC: A61K31/325 ,  C07C271/24

CPC classification number: C07C243/38 ,  C07C255/57 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2603/18 ,  C07D213/86 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D333/38

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

公开(公告)号：US20060178532A1

公开(公告)日：2006-08-10

申请号：US11343567

申请日：2006-01-31

Applicant: David Bolin ,  Christophe Michoud

Inventor： David Bolin ,  Christophe Michoud

IPC: C07C241/02

CPC classification number: C07D335/02 ,  C07C259/08 ,  C07C259/10 ,  C07C317/22 ,  C07C323/18 ,  C07C323/60 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/68 ,  C07D309/08 ,  C07D333/38

Abstract: Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供了式（1）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：US06221867B1

公开(公告)日：2001-04-24

申请号：US09464534

申请日：1999-12-15

Applicant: Kin-Chun Luk ,  Christophe Michoud

Inventor： Kin-Chun Luk ,  Christophe Michoud

IPC: C07D24136

CPC classification number: C07D487/04

Abstract: Disclosed are novel 4,5-pyrazinoxindoles having the formula These compounds inhibit or modulate protein kinases, in particular JNK protein kinases. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are useful as anti-inflammatory agents, particularly useful in the treatment of rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing such compounds, and methods for the treatment and/or control of inflammation, particularly in the treatment or control of rheumatoid arthritis, using these compounds.

Abstract translation: 公开了具有下式的新的4,5-吡嗪氧吲哚：这些化合物抑制或调节蛋白激酶，特别是JNK蛋白激酶。 这些化合物及其药学上可接受的盐和所述化合物的前药可用作抗炎剂，特别可用于治疗类风湿性关节炎。 还公开了含有这些化合物的药物组合物，以及使用这些化合物治疗和/或控制炎症，特别是治疗或控制类风湿性关节炎的方法。

公开(公告)号：US08962622B2

公开(公告)日：2015-02-24

申请号：US11899758

申请日：2007-09-07

Applicant: David Michael Goldstein ,  Levi Gong ,  Christophe Michoud ,  Wylie Solang Palmer ,  Achyutharao Sidduri

Inventor： David Michael Goldstein ,  Levi Gong ,  Christophe Michoud ,  Wylie Solang Palmer ,  Achyutharao Sidduri

IPC: C07D403/04 ,  A61K31/505 ,  C07D403/14

CPC classification number: C07D403/04 ,  C07D403/14

Abstract: Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.

Abstract translation: 式I的化合物调节jnk和cdk：或其药学上可接受的盐，其中R，R 1，R 2，R 3和m如本文所定义。

公开(公告)号：US08404859B2

公开(公告)日：2013-03-26

申请号：US13399106

申请日：2012-02-17

Applicant: Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

Inventor： Paul Gillespie ,  Christophe Michoud ,  Kenneth Carey Rupert ,  Kshitij Chhabilbhai Thakkar

IPC: A61K31/426 ,  A61K31/381 ,  C07D417/12 ,  C07D277/46 ,  C07D333/38

CPC classification number: C07D277/20 ,  C07D333/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

Abstract translation: 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症，例如哮喘和COPD。

公开(公告)号：US07504513B2

公开(公告)日：2009-03-17

申请号：US11703306

申请日：2007-02-07

Applicant: John Frederick Boylan ,  Jianping Cai ,  Nader Fotouhi ,  Paul Gillespie ,  Robert Alan Goodnow, Jr. ,  Kang Le ,  Christophe Michoud

Inventor： John Frederick Boylan ,  Jianping Cai ,  Nader Fotouhi ,  Paul Gillespie ,  Robert Alan Goodnow, Jr. ,  Kang Le ,  Christophe Michoud

IPC: A61K31/427 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D417/04

Abstract: The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

Abstract translation: 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。

公开(公告)号：US6153634A

公开(公告)日：2000-11-28

申请号：US464507

申请日：1999-12-15

Applicant: Kin-Chun Luk ,  Christophe Michoud ,  Steven Gregory Mischke

Inventor： Kin-Chun Luk ,  Christophe Michoud ,  Steven Gregory Mischke

IPC: C07D403/06 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/4188 ,  A61K31/424 ,  A61K31/429

CPC classification number: C07D403/06 ,  C07D487/04 ,  C07D513/04 ,  C09B23/04

Abstract: Disclosed are novel 4,5-azolo-oxindoles having the formula ##STR1## These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. Thus, these compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing these compounds, and methods for the treatment and/or prevention of cancer, particularly in the treatment or control of solid tumors using these compounds, as well as intermediates useful in the preparation of compounds of formula I.

Abstract translation: 公开了具有下式的新的4,5-azo-oxindoles这些化合物抑制细胞周期蛋白依赖性激酶（CDK），特别是CDK2。 因此，这些化合物及其药学上可接受的盐和所述化合物的前药是用于治疗或控制细胞增殖性疾病，特别是癌症的抗增殖剂。 还公开了含有这些化合物的药物组合物，以及用于治疗和/或预防癌症的方法，特别是使用这些化合物治疗或控制实体瘤的方法，以及可用于制备式I化合物的中间体。