Abstract:
The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
Abstract:
More particularly, the present invention relates to the crystal structure of the ErbB2, in particular the crystal structure of an extracellular portion of ErbB2 and to methods of using the crystal and related structural information to screen for and design compounds that interact with ErbB2, or variants of thereof.
Abstract:
A method, system, and computer program that assist consumers in quickly locating items in a store without requiring dedicated electronics equipment and without requiring the store to map the precise location of every item in the store. One exemplary method includes receiving at a host computer location information representative of locations of a plurality of items in a store; providing at least some of the location information to a mobile communications device operated by a consumer to enable the consumer to locate at least some of the items in the store; receiving from the mobile communications device corrected location information for at least one item in the store; and updating the location information in the host computer to account for the corrected location information.
Abstract:
This invention relates to the structure of members of the epidermal growth factor (EGF) receptor family and to receptor/ligand interactions. In particular, it relates to the field of using the EGF receptor family structure to select and screen for compounds that inhibit the formation of active receptor dimers.