公开(公告)号：US20150217249A1

公开(公告)日：2015-08-06

申请号：US14551141

申请日：2014-11-24

Applicant: Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob M. Hooker ,  Richard A. Ferrieri

Inventor： Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob M. Hooker ,  Richard A. Ferrieri

IPC: B01J8/02 ,  C01C3/02

CPC classification number: B01J8/0285 ,  B01J8/0278 ,  B01J8/0492 ,  B01J8/0496 ,  B01J2208/00415 ,  B01J2208/00823 ,  B01J2208/00893 ,  B01J2208/024 ,  C01C3/0212 ,  C01C3/0216 ,  C01C3/0229 ,  C07B59/00

Abstract: A method for providing 11C-labeled cyanides from 11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O2, wherein 11C labeled oxides are reduced with H2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% 11CH4, the 11CH4 is then combined with an excess of NH3 in a carrier/reaction stream flowing at an accelerated velocity and the combined 11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900° C., whereby a product stream comprising at least about 60% H 11CN is provided in less than 10 minutes from retrieval of the 11C labeled oxide.

Abstract translation: 在从含有O 2的被照射的高压气态靶中回收的目标气体流中，从11℃标记的氧化物中提供11C标记的氰化物的方法，其中在镍催化剂存在下，在压力和温度足够的情况下，用H 2还原11℃标记的氧化物 以形成包含至少约95％11CH4的产物流，然后将11CH4与以加速速度流动的载体/反应物流中的过量NH 3合并，然后将组合的11CH 4载体/反应物流与铂（Pt ）催化剂颗粒在至少约900℃的温度下负载在基本上化学反应性的热稳定性载体上，由此在不到10分钟内提供包含至少约60％H 11 CN的产物流， 11C标记氧化物。

公开(公告)号：US20130045151A1

公开(公告)日：2013-02-21

申请号：US13584033

申请日：2012-08-13

Applicant: Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob Hooker ,  Richard A. Ferrieri

Inventor： Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob Hooker ,  Richard A. Ferrieri

IPC: C01C3/02 ,  B01D53/02 ,  C07C1/20 ,  B01J8/00

CPC classification number: B01J8/0285 ,  B01J8/0278 ,  B01J8/0492 ,  B01J8/0496 ,  B01J2208/00415 ,  B01J2208/00823 ,  B01J2208/00893 ,  B01J2208/024 ,  C01C3/0212 ,  C01C3/0216 ,  C01C3/0229 ,  C07B59/00

Abstract: A method for providing 11C-labeled cyanides from 11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O2, wherein 11C labeled oxides are reduced with H2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% 11CH4, the 11CH4 is then combined with an excess of NH3 in a carrier/reaction stream flowing at an accelerated velocity and the combined 11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900° C., whereby a product stream comprising at least about 60% H11CN is provided in less than 10 minutes from retrieval of the 11C labeled oxide.

Abstract translation: 在从含有O 2的被照射的高压气态靶中回收的目标气体流中，从11℃标记的氧化物中提供11C标记的氰化物的方法，其中在镍催化剂存在下，在压力和温度足够的情况下，用H 2还原11℃标记的氧化物 以形成包含至少约95％11CH4的产物流，然后将11CH4与以加速速度流动的载体/反应物流中的过量NH 3合并，然后将组合的11CH 4载体/反应物流与铂（Pt ）催化剂颗粒在至少约900℃的温度下负载在基本上化学反应性热稳定的载体上，由此在不到10分钟内提供包含至少约60％H11CN的产物流，从11C 标记氧化物。

公开(公告)号：US5482865A

公开(公告)日：1996-01-09

申请号：US258053

申请日：1994-06-10

Applicant: Richard A. Ferrieri ,  David J. Schlyer ,  David Alexoff

Inventor： Richard A. Ferrieri ,  David J. Schlyer ,  David Alexoff

IPC: G21G1/10 ,  G01N37/00

CPC classification number: G21G1/10 ,  Y10S422/903 ,  Y10S436/813 ,  Y10T436/13 ,  Y10T436/25

Abstract: A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

Abstract translation: 一种用于制备用于正电子发射断层扫描的可注射形式的氧-15标记水（H2 [150]）的处理和处理装置，优选通过照射氮气和氢气流动气体靶产生的H2。 该装置包括用于接收和引导含有H 2 O气体和杂质（主要是氨（NH 3））的气体到无菌水中以捕集H 2 O并在无菌水中形成铵（NH 4 +）的收集器。 用于通过阳离子树脂移除含有H 2 O和NH 4 +的无菌水的装置从无菌水中除去NH 4 +。 将含有H 2 O的无菌水与盐溶液组合的装置产生可注射溶液。 优选地，该装置包括用于将溶液输送到用于注射到患者体内的注射器的装置。 此外，公开了一种用于制备用于正电子发射断层扫描的可注射形式的H 2 O的方法，其中所述方法既不需要同位素交换反应也不应用高温。

公开(公告)号：US20180250649A1

公开(公告)日：2018-09-06

申请号：US15909000

申请日：2018-03-01

Applicant: David ALEXOFF ,  Dohyun KIM ,  Hank KUNG

Inventor： David ALEXOFF ,  Dohyun KIM ,  Hank KUNG

IPC: B01J19/00 ,  G16H40/40

CPC classification number: B01J19/0006 ,  A61K51/0489 ,  A61K51/0497 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/00412 ,  B01J2219/00418 ,  B01J2219/0072 ,  C07B59/00 ,  G16H30/20 ,  G16H40/40 ,  G16H40/63 ,  G21G1/0005

Abstract: An automated apparatus and method for producing a 68Ga radiopharmaceutical is provided. The apparatus can direct fluid flow through a radiopharmaceutical generator, a vessel in a temperature controlled reactor, and a solid phase extraction cartridge to produce a final radiopharmaceutical product without human intervention under a clean environment.

公开(公告)号：US08932551B2

公开(公告)日：2015-01-13

申请号：US13584033

申请日：2012-08-13

Applicant: Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob Hooker ,  Richard A. Ferrieri

Inventor： Dohyun Kim ,  David Alexoff ,  Sung Won Kim ,  Jacob Hooker ,  Richard A. Ferrieri

IPC: C01C3/02 ,  C07B59/00

CPC classification number: B01J8/0285 ,  B01J8/0278 ,  B01J8/0492 ,  B01J8/0496 ,  B01J2208/00415 ,  B01J2208/00823 ,  B01J2208/00893 ,  B01J2208/024 ,  C01C3/0212 ,  C01C3/0216 ,  C01C3/0229 ,  C07B59/00

Abstract: A method for providing 11C-labeled cyanides from 11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O2 is provided, wherein 11C labeled oxides are reduced with H2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% 11CH4 , the 11CH4 is then combined with an excess of NH3 in a carrier/reaction stream flowing at an accelerated velocity and the combined 11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 ° C., whereby a product stream comprising at least about 60%H11CN is provided in less than 10 minutes from retrieval of the 11C labeled oxide.

Abstract translation: 提供了一种从含有O 2的被照射的高压气态靶中提取的目标气体流中的11C标记的氧化物提供11C标记的氰化物的方法，其中在镍催化剂存在下，在压力下，用H 2还原11℃标记的氧化物， 温度足以形成包含至少约95％11CH4的产物流，然后将11CH4与以加速速度流动的载体/反应物流中的过量NH 3合并，然后将组合的11CH 4载体/反应物流与铂 （Pt）催化剂颗粒，其在至少约900℃的温度下负载在基本上化学反应性的热稳定性载体上，由此在不到10分钟内提供包含至少约60％H11CN的产物流， 11C标记的氧化物。