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    Surgical clamps
    4.
    发明授权
    Surgical clamps 失效
    手术钳

    公开(公告)号：US07329266B2

    公开(公告)日：2008-02-12

    申请号：US10521422

    申请日：2002-07-26

    Applicant: Alistair Royse ,  Brett Hamilton ,  David Berry ,  Michael Kerr

    Inventor： Alistair Royse ,  Brett Hamilton ,  David Berry ,  Michael Kerr

    IPC: A61B17/08

    CPC classification number: A61B17/122

    Abstract: An arterial clamp has opposed clamping posts arranged to lie at opposite sides of an artery to clamp the artery between opposed clamping faces of the posts. The posts are carried by a pair of arms pivotally movable one relative to the other to move the posts into clamping relationship with the artery. A ratchet device releasably locks the arms in a selected clamping position. The clamp including posts, arms, and ratchet device is formed as a one-piece plastics moulding.

    Abstract translation: 动脉夹具具有相对的夹持柱，其布置成位于动脉的相对侧以将动脉夹持在柱的相对夹紧面之间。 柱由一对相对于另一个臂枢转运动的臂支撑，以将柱移动成与动脉夹紧关系。 棘爪装置可释放地将臂锁定在选定的夹紧位置。 包括柱，臂和棘轮装置的夹具形成为一体式塑料模制件。

    Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac
    5.
    发明授权
    Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac 失效
    通过在羊水囊中注射天然存在的蛋白质来修复破裂的膜

    公开(公告)号：US07175647B2

    公开(公告)日：2007-02-13

    申请号：US10278726

    申请日：2002-10-23

    Applicant: David Berry

    Inventor： David Berry

    IPC: A61B17/08 ,  A61B19/00

    CPC classification number: A61K38/38 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/42 ,  A61K2300/00

    Abstract: The present invention provides compositions and methods for use in treatment of premature rupture of membranes. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.

    Abstract translation: 本发明提供了用于治疗膜过早破裂的组合物和方法。 本发明的组合物包括治疗量的禽蛋白组合物。 优选地，组合物包括纯化的厚蛋白蛋白质，卵蛋白质。 本发明的方法包括将有效量的组合物注射到患者的过早破裂的羊膜囊中，以密封破裂。

    Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
    6.
    发明申请
    Fluorous oligonucleotide reagents and affinity purification of oligonucleotides 审中-公开
    氟寡核苷酸试剂和寡核苷酸的亲和纯化

    公开(公告)号：US20060178507A1

    公开(公告)日：2006-08-10

    申请号：US11320218

    申请日：2005-12-28

    Applicant: David Berry ,  William Pearson

    Inventor： David Berry ,  William Pearson

    IPC: C07H21/04

    CPC classification number: C07H21/00 ,  C07B63/00 ,  C07B2200/11 ,  C07C245/08 ,  C07F9/2408 ,  C07F9/6561 ,  C07H19/067 ,  C07H19/073 ,  C07H19/167 ,  C07H19/173 ,  C07H21/04 ,  C07H23/00

    Abstract: Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.

    Abstract translation: 含氟标记的寡核苷酸试剂和利用其的寡核苷酸纯化方法，所述方法包括：使用各自携带至少一个氟基的寡核苷酸试剂合成寡核苷酸试剂以产生合成产物和试剂的混合物，所述混合物包含至少一种靶合成寡核苷酸轴承 至少一个氟团; 使混合物通过对至少一个氟族具有亲和力的分离介质，使得带有至少一个氟团的靶合成寡核苷酸被分离介质吸附; 用至少一种第一溶剂洗涤分离介质以选择性地从其中分离除了至少一种带有至少一个氟基的至少一种目标合成寡核苷酸之外的所述异源混合物的所有合成产物和试剂; 并随后使用或不与氟基离开分离介质中的至少一种合成的寡核苷酸。

    Methods and products related to the intracellular delivery of polysaccharides
    7.
    发明申请
    Methods and products related to the intracellular delivery of polysaccharides 审中-公开
    与多糖细胞内转运相关的方法和产品

    公开(公告)号：US20060083711A1

    公开(公告)日：2006-04-20

    申请号：US11107360

    申请日：2005-04-15

    Applicant: David Berry ,  Daniel Anderson ,  David Lynn ,  Ram Sasisekharan ,  Robert Langer

    Inventor： David Berry ,  Daniel Anderson ,  David Lynn ,  Ram Sasisekharan ,  Robert Langer

    IPC: A61K31/785 ,  A61K31/737 ,  A61K31/727

    CPC classification number: A61K45/06 ,  A61K31/726 ,  A61K31/727 ,  A61K31/737 ,  A61K31/785 ,  A61K47/593 ,  A61K2300/00

    Abstract: The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as cancer. The invention is still other aspects relates to improving cell viability. The invention also relates to the delivery of polysaccharides while avoiding unwanted effects of the polysaccharides. For example, heparin can be delivered while avoiding its anticoagulant effects.

    Abstract translation: 本发明部分地涉及多糖的细胞内递送的方法和组合物。 特别地，所述方法和组合物涉及糖胺聚糖如肝素的细胞内递送。 本发明在其它方面涉及使用糖胺聚糖来治疗增殖性疾病如癌症。 本发明还涉及提高细胞活力的其它方面。 本发明还涉及多糖的递送，同时避免多糖的不期望的影响。 例如，可以输送肝素同时避免其抗凝血作用。

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