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公开(公告)号：US09070006B2
公开(公告)日：2015-06-30
申请号：US11957084
申请日：2007-12-14
Applicant: Kam Lin Wong , David Zahniser , Kathy Mui , Jim Linder , Ellen Sheets
Inventor： Kam Lin Wong , David Zahniser , Kathy Mui , Jim Linder , Ellen Sheets
CPC classification number: G06T7/0012 , G06K9/00147 , G06T7/42 , G06T2207/10056 , G06T2207/30024
Abstract: Components, e.g., background, cytoplasm, nucleus and nucleolus, of a biological specimen are identified using multi-wavelength analysis. Specimen components, such as nucleoli, are selected, and a determination is made whether cells having nucleoli are cancer cells or regular repair cells based on one or more physical characteristics of the identified component. The physical characteristics can be one or more of a shape, size, texture and gray value.
Abstract translation: 使用多波长分析来鉴定生物样本的组分，例如背景，细胞质，细胞核和核仁。 选择样品组分，例如核仁，并且基于鉴定的组分的一种或多种物理特性来确定具有核仁的细胞是癌细胞还是常规修复细胞。 物理特性可以是形状，尺寸，纹理和灰度值中的一个或多个。
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2.发明申请METHOD AND SYSTEM FOR IDENTIFYING BIOLOGICAL SPECIMEN SLIDES USING UNIQUE SLIDE FINGERPRINTS 有权使用独特滑动指纹识别生物样本滑块的方法和系统公开(公告)号：US20100021037A1
公开(公告)日：2010-01-28
申请号：US12340232
申请日：2008-12-19
Applicant: Michael Zahniser , David Zahniser
Inventor： Michael Zahniser , David Zahniser
IPC: G06K9/00
CPC classification number: G02B21/244 , G02B21/34
Abstract: Method and system for processing specimen slides. A first image of a unique feature, such as a fiducial mark, of a specimen slide is acquired, and a second image of the same region of a fiducial mark is acquired at a later time. The first and second fiducial mark images are compared in order to determine whether they are images of the same fiducial mark of the same specimen slide, thereby allowing the system to detect when one specimen slide has been swapped with another specimen slide. The comparison may also involve images of multiple features on the specimen carrier, e.g., sets of multiple fiducial marks.
Abstract translation: 标本片的处理方法及系统。 获取样本幻灯片的独特特征（例如基准标记）的第一图像，并且在稍后时间获取基准标记的相同区域的第二图像。 比较第一和第二基准标记图像以确定它们是否是相同样本载玻片的相同基准标记的图像，从而允许系统检测何时一个标本载片与另一个标本载玻片交换。 该比较还可以包括样本载体上的多个特征的图像，例如多个基准标记的集合。
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3.发明申请METHOD OF DETERMINING A COMPLETE BLOOD COUNT AND A WHITE BLOOD CELL DIFFERENTIAL COUNT 有权确定完全血液计数和白血病细胞差异计数的方法公开(公告)号：US20090269799A1
公开(公告)日：2009-10-29
申请号：US12430885
申请日：2009-04-27
Applicant: James Winkelman , Milenko Tanasijevic , David Zahniser
Inventor： James Winkelman , Milenko Tanasijevic , David Zahniser
CPC classification number: G01N15/1475 , G01N1/2813 , G01N1/312 , G01N21/255 , G01N33/49 , G01N35/00029 , G01N35/00871 , G01N35/1016 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/1497 , G01N2035/00138 , G01N2035/00465 , G01N2035/0091 , G01N2201/062 , G01N2201/126 , G01N2333/805 , G06K9/4652 , G06K9/6267 , G06T7/0012 , H04N5/2256 , H04N5/23293 , H04N5/265
Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。
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4.发明申请METHODS AND SYSTEMS FOR PROCESSING BIOLOGICAL SPECIMENS UTILIZING MULTIPLE WAVELENGTHS 有权用于处理多个波长的生物样本的方法和系统公开(公告)号：US20090087074A1
公开(公告)日：2009-04-02
申请号：US11864744
申请日：2007-09-28
Applicant: Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
Inventor： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
IPC: G06K9/00
CPC classification number: G06K9/00147 , G06K9/033 , G06K9/6253
Abstract: Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.
Abstract translation: 方法，系统和计算机可读介质，用于处理标本载玻片携带的一个或多个生物样本。 获取样本中的对象的图像，并且识别获取的图像中的感兴趣对象。 可以在多个波长处获取所识别的感兴趣对象的附加图像。 基于提取的特征的概率模型，从图像中提取感兴趣对象的细胞特征，并且可以将其用于分类样本，例如正常或可疑/异常。
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公开(公告)号：US07433026B2
公开(公告)日：2008-10-07
申请号：US11313365
申请日：2005-12-20
Applicant: Scott Wolpert , David Zahniser
Inventor： Scott Wolpert , David Zahniser
IPC: G01N33/48
CPC classification number: G02B21/08 , G01J3/18 , G02B21/084 , G06K9/00134 , G06K9/2027
Abstract: Techniques are provided for illuminating cytological specimens using light emitting diodes (LEDs). In one implementation, a pulse width modulated (PWM) LED source allows for color and intensity adjustment. A user may select the desired color and intensity of light, or the desired color and intensity may be electronically calculated. Using various colors of LEDs, such as red, blue, and green LEDs, various colors can be produced by modulating each LED duty cycle, for example, using a PWM controller.
Abstract translation: 提供了使用发光二极管（LED）照射细胞学标本的技术。 在一个实现中，脉冲宽度调制（PWM）LED源允许颜色和亮度调节。 用户可以选择所需的光的颜色和强度，或者可以电子地计算所需的颜色和强度。 使用诸如红色，蓝色和绿色LED的各种颜色的LED，可以通过例如使用PWM控制器调制每个LED占空比来产生各种颜色。
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Patent Agency Ranking
公开(公告)号：US20070139638A1
公开(公告)日：2007-06-21
申请号：US11313365
申请日：2005-12-20
Applicant: Scott Wolpert , David Zahniser
Inventor： Scott Wolpert , David Zahniser
IPC: G01N33/48
CPC classification number: G02B21/08 , G01J3/18 , G02B21/084 , G06K9/00134 , G06K9/2027
Abstract: Techniques are provided for illuminating cytological specimens using light emitting diodes (LEDs). In one implementation, a pulse width modulated (PWM) LED source allows for color and intensity adjustment. A user may select the desired color and intensity of light, or the desired color and intensity may be electronically calculated. Using various colors of LEDs, such as red, blue, and green LEDs, various colors can be produced by modulating each LED duty cycle, for example, using a PWM controller.
Abstract translation: 提供了使用发光二极管（LED）照射细胞学标本的技术。 在一个实现中，脉冲宽度调制（PWM）LED源允许颜色和亮度调节。 用户可以选择所需的光的颜色和强度，或者可以电子地计算所需的颜色和强度。 使用诸如红色，蓝色和绿色LED的各种颜色的LED，可以通过例如使用PWM控制器调制每个LED占空比来产生各种颜色。
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公开(公告)号：US20060077538A1
公开(公告)日：2006-04-13
申请号：US11236407
申请日：2005-09-26
Applicant: David Zahniser , Theodore Geiselman , Roy Ostgaard , James Woodard , Kenneth Scott , Scott Danhof , Jan Yates , Larry Schluer , Joseph Zambanini , Joseph Juratovac , Matthew Zelinski , James Mank , Michael Ulrich , Howard Greene , Randal Chinnock , Thomas Haubert
Inventor： David Zahniser , Theodore Geiselman , Roy Ostgaard , James Woodard , Kenneth Scott , Scott Danhof , Jan Yates , Larry Schluer , Joseph Zambanini , Joseph Juratovac , Matthew Zelinski , James Mank , Michael Ulrich , Howard Greene , Randal Chinnock , Thomas Haubert
IPC: G02B21/00
CPC classification number: G01N1/30 , G01N15/1012 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/3151 , G01N2015/1006 , G01N2015/1472 , G01N2015/1488 , G02B21/0016 , G02B21/32 , G02B21/34 , G06K9/00134 , G06T7/0012 , G06T7/73 , G06T2207/30024
Abstract: The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imaging system and methods for accommodating vibration in the imaging system. In particular, the methods and apparatus may be applied to the automated analysis of cytological specimen slides.
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公开(公告)号：US11047791B2
公开(公告)日：2021-06-29
申请号：US13526223
申请日：2012-06-18
Applicant: David Zahniser , Michael Zahniser , Adam Yie
Inventor： David Zahniser , Michael Zahniser , Adam Yie
Abstract: Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.
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9.发明授权Method of determining a complete blood count and a white blood cell differential count 有权确定完整血细胞计数和白细胞差异计数的方法公开(公告)号：US09017610B2
公开(公告)日：2015-04-28
申请号：US12430885
申请日：2009-04-27
Applicant: James Winkelman , Milenko Tanasijevic , David Zahniser
Inventor： James Winkelman , Milenko Tanasijevic , David Zahniser
CPC classification number: G01N15/1475 , G01N1/2813 , G01N1/312 , G01N21/255 , G01N33/49 , G01N35/00029 , G01N35/00871 , G01N35/1016 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/1497 , G01N2035/00138 , G01N2035/00465 , G01N2035/0091 , G01N2201/062 , G01N2201/126 , G01N2333/805 , G06K9/4652 , G06K9/6267 , G06T7/0012 , H04N5/2256 , H04N5/23293 , H04N5/265
Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。
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10.发明授权公开(公告)号：US08321136B2
公开(公告)日：2012-11-27
申请号：US10794334
申请日：2004-03-05
Applicant: Kam Lin Wong , Louise Isenstein , David Zahniser
Inventor： Kam Lin Wong , Louise Isenstein , David Zahniser
CPC classification number: G06K9/00147 , G01N15/1475 , G06T7/0012 , G06T2207/10056 , G06T2207/30004 , G06T2207/30024
Abstract: The present invention relates to a method and system for classifying biological specimen. A number of objects of interest are identified in a biological specimen. The nuclear area and nuclear integrated optical density for each object of interest in the specimen are measured and used for generating a scatter plot. The specimen is classified as normal or suspicious based on the distribution of points within the scatter plot.
Abstract translation: 本发明涉及一种用于分类生物样本的方法和系统。 在生物样本中识别出许多感兴趣的物体。 测量样品中感兴趣的每个物体的核面积和核集成光密度，并用于产生散点图。 根据分散图中点的分布，将样本分类为正常或可疑。
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