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    Colorimetric detection of nucleic acid amplification
    2.
    发明授权
    Colorimetric detection of nucleic acid amplification 有权

    公开(公告)号：US10253357B2

    公开(公告)日：2019-04-09

    申请号：US15306240

    申请日：2015-04-24

    Applicant: Diassess Inc.

    Inventor： Debkishore Mitra ,  Ivan Krastev Dimov ,  John Robert Waldeisen

    IPC: C12P19/34 ,  C12Q1/6844

    Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.

    Image-based disease diagnostics using a mobile device
    3.
    发明授权
    Image-based disease diagnostics using a mobile device 有权

    公开(公告)号：US10146909B2

    公开(公告)日：2018-12-04

    申请号：US15481349

    申请日：2017-04-06

    Applicant: Diassess Inc.

    Inventor： Ivan Krastev Dimov ,  Frank B. Myers, III ,  John Robert Waldeisen ,  Debkishore Mitra

    IPC: G01N33/50 ,  G16H50/20 ,  G06F19/00 ,  A61B5/00 ,  C12Q1/70 ,  G01N33/569 ,  G06T7/00

    Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.

    Colorimetric Detection of Nucleic Acid Amplification
    4.
    发明申请
    Colorimetric Detection of Nucleic Acid Amplification 审中-公开

    公开(公告)号：US20190309356A1

    公开(公告)日：2019-10-10

    申请号：US16359913

    申请日：2019-03-20

    Applicant: Diassess Inc.

    Inventor： Debkishore Mitra ,  Ivan Krastev Dimov ,  John Robert Waldeisen

    IPC: C12Q1/6844

    Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.

    IMAGE-BASED DISEASE DIAGNOSTICS USING A MOBILE DEVICE
    5.
    发明申请
    IMAGE-BASED DISEASE DIAGNOSTICS USING A MOBILE DEVICE 审中-公开

    公开(公告)号：US20190050988A1

    公开(公告)日：2019-02-14

    申请号：US16155829

    申请日：2018-10-09

    Applicant: Diassess Inc.

    Inventor： Ivan Krastev Dimov ,  Frank B. Myers, III ,  John Robert Waldeisen ,  Debkishore Mitra

    IPC: G06T7/00 ,  G06T7/90 ,  G06T7/60 ,  G06F19/24 ,  A61B5/00

    Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.

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