公开(公告)号：US09220809B2

公开(公告)日：2015-12-29

申请号：US13310282

申请日：2011-12-02

Applicant: Aurelie Brizard ,  Emial Pesters ,  Dirk Jan Broer ,  Rudolf Mathias Johannes Nicolaas Lamariche ,  Anton William Bosman ,  Henricus Marie Janssen ,  Serge Hendrikus Mathÿs Söntjens

Inventor： Aurelie Brizard ,  Emial Pesters ,  Dirk Jan Broer ,  Rudolf Mathias Johannes Nicolaas Lamariche ,  Anton William Bosman ,  Henricus Marie Janssen ,  Serge Hendrikus Mathÿs Söntjens

IPC: A61K49/12 ,  C08L27/12 ,  A61L27/26 ,  A61L27/50

CPC classification number: A61L27/26 ,  A61K49/126 ,  A61L27/50 ,  C08L27/12

Abstract: A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent in 19F magnetic resonance imaging (MRI) of a solid object, said solid object comprising said contrast agent. The invention relates to a solid object comprising a structural component and an imaging component, wherein the imaging component is at least one fluorinated polymer. The invention relates to a method for 19F MRI in solid state using a contrast agent comprising a fluorinated polymer as well as a method for in vivo visualizing a scaffold. It further relates to a method for in vivo monitoring the degradation of a solid object in time, wherein the degradation is monitored in time by using 19F MRI to visualize the solid object, and wherein the amount of degradation of the solid object is determined based on the decrease in the visibility of the amount of 19F.

Abstract translation: 在固体物体的19F磁共振成像（MRI）中使用玻璃化转变温度低于40℃的氟化聚合物作为造影剂的方法，所述固体物体包括所述造影剂。 本发明涉及包含结构组分和成像组分的固体物体，其中成像组分是至少一种氟化聚合物。 本发明涉及使用包含含氟聚合物的造影剂的固态19F MRI的方法以及体内可视化支架的方法。 本发明还涉及一种用于在时间上体内监测固体物质的降解的方法，其中通过使用19F MRI可视化固体物质来及时监测降解，其中固体物质的降解量基于 19F的能见度下降。

公开(公告)号：US20130101804A1

公开(公告)日：2013-04-25

申请号：US13695707

申请日：2011-05-03

Applicant: Dirk Brokken ,  Dirk Jan Broer ,  Floris Maria Hermansz Crompvoets ,  Hendrik De Koning ,  Wendy Mirelle Martam

Inventor： Dirk Brokken ,  Dirk Jan Broer ,  Floris Maria Hermansz Crompvoets ,  Hendrik De Koning ,  Wendy Mirelle Martam

IPC: H01H3/02

CPC classification number: H01H3/02 ,  G06F3/016 ,  G09B21/003 ,  H01L41/04 ,  H01L41/0986 ,  H01L41/45 ,  Y10T428/24612

Abstract: The invention relates to an actuator device (400) comprising an active layer (410) having directly or indirectly a skin layer (420) on top that can be touched by when in use by a user. The configuration of the active layer (410) can controllably be changed in an extension direction (x, y), and the skin layer (420) comprises a plurality of elevations (E) and intermediate recesses (R). Due to its structure, the skin layer (420) does not hinder conformation changes of the active layer (410) in the extension direction, while it provides favorable tactile characteristics of the actuator device (400). The active layer (410) may particularly comprise an electroactive polymer (EAP). The skin layer (420) may be composed of a plurality of grains isolated from each other, or it may comprise a thin surface layer (421) that is stiffer than the active layer (410).

Abstract translation: 本发明涉及一种致动器装置（400），该致动器装置（400）包括有效层（410），其在顶部具有直接或间接的表皮层（420），当使用者在使用时可以触摸该层。 有源层（410）的构造可以可控地沿延伸方向（x，y）改变，并且表层（420）包括多个高度（E）和中间凹槽（R）。 由于其结构，表皮层（420）不会阻碍活性层（410）在延伸方向上的构象变化，同时其提供致动器装置（400）的良好的触觉特性。 活性层（410）可以特别包括电活性聚合物（EAP）。 表层（420）可以由彼此分离的多个晶粒组成，或者它可以包括比有源层（410）更硬的薄表面层（421）。

公开(公告)号：US20120296224A1

公开(公告)日：2012-11-22

申请号：US13521768

申请日：2011-01-10

Applicant: Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

Inventor： Mareike Klee ,  Christianus Martinus Van Heesch ,  Dirk Jan Broer ,  Jacob Roger Haartsen

IPC: A61B5/026

CPC classification number: A61B5/026 ,  A61B5/413 ,  A61B5/6833 ,  A61B5/6876 ,  A61B5/6884 ,  A61B2560/0412

Abstract: The present invention relates to determining or measuring a biological, physical or physiological parameter of an object (10) by a sensor (2). It may be beneficial to constantly monitor or determine a biological, physical or physiological parameter of an object (10) by a sensor (2), subsequently allowing for a preferred removal of the sensor (2) from object (10) when the monitoring is no longer required. Accordingly, a sensor (2) is provided, e.g. a flow sensor, employing a degradable adhesive (8) for attachment of the sensor (2) to the object (10). The degradable adhesive (8) may be degradable e.g. by time, by exposure to a certain measure, e.g. induced heat, or substance for detaching the sensor (2) from the object (10) for subsequent removal of the sensor (2).

Abstract translation: 本发明涉及通过传感器（2）来确定或测量物体（10）的生物，物理或生理参数。 通过传感器（2）持续地监测或确定物体（10）的生物，物理或生理参数可能是有益的，随后允许当监测是（...）时将传感器（2）从对象（10）中移除， 不再需要。 因此，提供传感器（2），例如 流量传感器，使用用于将传感器（2）附接到物体（10）的可降解粘合剂（8）。 可降解粘合剂（8）可以是降解的。 通过暴露于某种措施，例如， 感应的热量或用于将传感器（2）从物体（10）分离以用于随后去除传感器（2）的物质。

公开(公告)号：US08040318B2

公开(公告)日：2011-10-18

申请号：US10597601

申请日：2005-01-27

Applicant: Peter Alexander Duine ,  Dirk Jan Broer ,  Marcellinus Petrus Carolus Krijn ,  Volker Schoellmann ,  Mark Thomas Johnson ,  Patrick John Baesjou ,  Eduard Matheus Johannes Niessen

Inventor： Peter Alexander Duine ,  Dirk Jan Broer ,  Marcellinus Petrus Carolus Krijn ,  Volker Schoellmann ,  Mark Thomas Johnson ,  Patrick John Baesjou ,  Eduard Matheus Johannes Niessen

IPC: G09G3/34 ,  G02B26/00

CPC classification number: G02F1/167 ,  G02F1/134363 ,  G09G3/344

Abstract: The electrophoretic display panel(1) for displaying a picture and subsequently displaying a subsequent picture has a pixel(2) having an electrophoretic medium (5) having first and second charged particles (6,7) and an optical state depending on the positions of the particles (6,7) in the common region (30) of the pixel (2). Furthermore, transition control means are able to control a transition of the first and the second particles (6,7) being in substantially separated domains of the common region (30) for displaying the picture to substantially separated domains of the common region (30) for displaying the subsequent picture. For the display panel (1) to be able to have an attainable optical state for displaying the subsequent picture which is unequal to the optical state determined by the mixture of the first and second particles (6,7), even if the particles (6,7) have substantially equal electrophoretic mobilities, the transition control means are further able to control the first and the second particles (6,7) to be in substantially separated domains of the common region (30) during the transition.

Abstract translation: 用于显示图像并随后显示后续图像的电泳显示面板（1）具有具有第一和第二带电粒子（6,7）的电泳介质（5）的像素（2）和取决于 像素（2）的公共区域（30）中的粒子（6,7）。 此外，过渡控制装置能够控制在公共区域（30）的基本分离的区域中的第一和第二颗粒（6,7）的转变，用于将图像显示为公共区域（30）的基本分离的区域， 用于显示后续图像。 为了使显示面板（1）能够具有可获得的光学状态，用于显示由第一和第二颗粒（6,7）的混合物确定的不同于光学状态的后续图像，即使颗粒（6） ，7）具有基本相等的电泳迁移率，转变控制装置还能够在转变期间将第一和第二颗粒（6,7）控制在公共区域（30）的基本上分离的区域中。

公开(公告)号：US20100015557A1

公开(公告)日：2010-01-21

申请号：US12438185

申请日：2007-08-17

Applicant: Mark Thomas Johnson ,  Martinus Hermanus Wilhelmus Maria Van Delden ,  Dirk Jan Broer

Inventor： Mark Thomas Johnson ,  Martinus Hermanus Wilhelmus Maria Van Delden ,  Dirk Jan Broer

IPC: G03F7/20

CPC classification number: G02F1/167

Abstract: A method for forming a sealed cell structure is disclosed. The sealed cell structure comprises first (10) and second (12) substrates that are spaced apart by a plurality of partition walls (14). The partition walls define a plurality of cells (18, 19) between the first and second substrates. At least one of the substrates and the partition walls have a layer (16, 22, 30) of photo-embossing material on them. A latent image is written (112) onto the photo-embossing material, and then the image is developed, thereby causing expansion of the photo-embossing material in the areas (114) according to the pattern of the latent image. The expansion of the photo-embossing material causes the cells to be sealed apart from one another.

Abstract translation: 公开了形成密封电池结构的方法。 密封单元结构包括由多个间隔壁（14）隔开的第一（10）和第二（12）基板。 分隔壁在第一和第二基板之间限定多个单元（18,19）。 至少一个基板和分隔壁在其上具有光压纹材料层（16,22,30）。 将潜像写入（112）到光压花材料上，然后显影图像，从而根据潜像的图案使区域（114）中的光压花材料膨胀。 光压花材料的膨胀使细胞彼此分开密封。

公开(公告)号：US20090165877A1

公开(公告)日：2009-07-02

申请号：US12278417

申请日：2007-02-01

Applicant: Jacob Marinus Jan Den Toonder ,  Dirk Jan Broer ,  Auke Ronald Van Dijken

Inventor： Jacob Marinus Jan Den Toonder ,  Dirk Jan Broer ,  Auke Ronald Van Dijken

IPC: B81B7/02 ,  F15C3/00 ,  B81C1/00

CPC classification number: F04D33/00 ,  B01F13/0059 ,  B01F13/0091 ,  B01F13/0827 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2400/0484 ,  F04B19/006 ,  Y10T29/49229 ,  Y10T29/494 ,  Y10T137/2191 ,  Y10T137/2213

Abstract: A micro-fluidic system comprises at least one micro-channel having a wall (14), a plurality of ciliary actuator elements (71) attached to said wall (14), said ciliary actuator elements (71) having an original shape when not subjected to a liquid, and means for applying stimuli to said plurality of ciliary actuator elements (71) so as to cause a change in their shape from an initial shape to an end shape. The ciliary actuator elements (71) are adapted to respond to the presence of a particular liquid by changing their original shape into the initial shape. The response to the presence of the particular liquid may be a curving of the original shape of the ciliary actuator element. Application of stimuli to the plurality of ciliary actuator elements provides a way to locally manipulate the flow of complex fluids in a micro-fluidic system.

Abstract translation: 微流体系统包括至少一个具有壁（14）的微通道，附接到所述壁（14）的多个纤毛致动器元件（71），所述纤维致动器元件（71）当不受影响时具有原始形状 以及用于将刺激施加到所述多个纤毛致动器元件（71）以使其形状从初始形状改变为端部形状的装置。 纤毛致动器元件（71）适于通过将其原始形状改变为初始形状来响应特定液体的存在。 对特定液体的存在的响应可以是纤毛致动器元件的原始形状的弯曲。 刺激对多个纤毛致动器元件的应用提供了一种在微流体系统中局部地操纵复杂流体的流动的方式。

公开(公告)号：US20080312106A1

公开(公告)日：2008-12-18

申请号：US12096920

申请日：2006-11-28

Applicant: Ralph Kurt ,  Dirk Jan Broer ,  Roel Penterman ,  Emiel Peeters

Inventor： Ralph Kurt ,  Dirk Jan Broer ,  Roel Penterman ,  Emiel Peeters

IPC: C40B60/04 ,  B01J19/00 ,  B05D3/06

CPC classification number: G01N33/54313

Abstract: The invention relates to a substrate material for analyzing fluids which has first areas with a high porosity and second areas with a lower porosity.

Abstract translation: 本发明涉及一种用于分析具有高孔隙率的第一区域和具有较低孔隙率的第二区域的流体的基底材料。

公开(公告)号：US20080264058A1

公开(公告)日：2008-10-30

申请号：US10597580

申请日：2005-01-26

Applicant: Dirk Jan Broer ,  Christiane Maria Rosette De Witz ,  Grietje Neeltje Mol

Inventor： Dirk Jan Broer ,  Christiane Maria Rosette De Witz ,  Grietje Neeltje Mol

IPC: C09K19/38 ,  C09K19/56 ,  B81B3/00 ,  F03G7/06

CPC classification number: B81B3/0072 ,  C09K19/38 ,  C09K2219/03

Abstract: A foil moveable by non-mechanical means, such as light or heat, comprises an alternating array of first and second foil sections each resiliently and non-mechanically moveable between a flattened state and a bent state. The direction in which the first foil sections bend, when moved from the flattened to the bent state, is opposite to the direction in which the second foil sections bend when moved from the flattened to the bent state. When, in the flattened state, non-mechanically stimulating the first and second foil sections in unison, the first and second foil sections bend in opposite directions causing the foil to wrinkle, which results in a movement which is substantially linear. Using a different or removing the non-mechanical stimulus, the foil sections can be made to unbend resulting in a flattening and expansion of the foil to its original shape.

Abstract translation: 可通过诸如光或热的非机械装置移动的箔包括第一和第二箔片段的交替阵列，每个片状部分在扁平状态和弯曲状态之间弹性地且不可机械地移动。 当从扁平状态移动到弯曲状态时，第一箔片部分弯曲的方向与第二箔片部分从扁平状态移动到弯曲状态时弯曲的方向相反。 当处于扁平状态时，第一和第二箔部分一致地非机械地刺激第一和第二箔片部分，第一和第二箔片部分在相反方向上弯曲，导致箔片起皱纹，这导致基本上线性的运动。 使用不同的或去除非机械刺激，箔片部分可以制成不弯曲，导致箔的平坦化和膨胀到其原始形状。

公开(公告)号：US20080258108A1

公开(公告)日：2008-10-23

申请号：US10597582

申请日：2005-01-26

Applicant: Dirk Jan Broer ,  Christiane Maria Rosette De Witz ,  Grietje Neeltie Mol

Inventor： Dirk Jan Broer ,  Christiane Maria Rosette De Witz ,  Grietje Neeltie Mol

IPC: C09K19/38

CPC classification number: C09K19/38 ,  C09K19/60 ,  C09K2219/03

Abstract: A flexible foil which is moveable by means of light comprises a dye which is capable of changing shape when absorbing light of a predetermined wavelength. The dye is dispersed in the foil such that, near at least one major surface of the foil, the dye is anisotropically oriented. Transverse to the foil, the concentration and/or orientation of the dye changes in an asymmetric manner. The change in orientation and/or concentration is such that, when exposed to light of the predetermined wavelength, the flexible foil moves. When exposed the dye changes shape which change in shape causes a change in lateral dimension of the foil which change in lateral dimension is, due to the change in concentration and/or orientation of the dye, different at different locations with the foil. This causes the flexible foil to move or more particular bend. In a specific embodiment the movement is reversible.

Abstract translation: 通过光可移动的柔性箔包括当吸收预定波长的光时能够改变形状的染料。 染料分散在箔中，使得在箔的至少一个主表面附近，染料是各向异性取向的。 与箔横切，染料的浓度和/或取向以不对称方式变化。 取向和/或浓度的变化使得当暴露于预定波长的光时，柔性箔移动。 当染料改变形状改变形状时，由于染料的浓度和/或取向的变化，箔的侧向尺寸的变化导致横向尺寸的变化，其在不同位置处与箔不同。 这导致柔性箔移动或更特定的弯曲。 在具体实施例中，移动是可逆的。

公开(公告)号：US06864933B2

公开(公告)日：2005-03-08

申请号：US09950475

申请日：2001-09-10

Applicant: Dirk Jan Broer ,  Cornelis Antonius Van Den Heuvel ,  Gerardus Gegorius Petrus Van Gorkom

Inventor： Dirk Jan Broer ,  Cornelis Antonius Van Den Heuvel ,  Gerardus Gegorius Petrus Van Gorkom

IPC: G02B26/00 ,  F21V8/00 ,  G02B5/28 ,  G02B26/02 ,  G02F1/13 ,  G09F9/37 ,  G02F1/1335

CPC classification number: G02B26/001 ,  G02B5/285

Abstract: A light valve for controlled transmission of light comprises first and second elements at least one of which is controllably movable into optical contact with the other element. Means are provided for projecting light on the first of the two elements on the side remote from the second of the two elements. Each facing side of the elements is provided with an interference filter layer, which interference filter layers, when being in optical contact with each other, have a transmission for light projected onto the light valve in a wavelength range determined by the interference filter layers. This transmission differs from the transmission that would occur in the case where the interference filter layers are not in optical contact with each other.

Abstract translation: 用于光的受控传输的光阀包括第一和第二元件，其中至少一个可控制地移动成与另一元件光学接触。 提供了用于将光投射在远离两个元件中的第二个的一侧上的两个元件中的第一元件上的装置。 每个元件的侧面设置有干涉滤光层，当干涉滤光层彼此光学接触时，干涉滤光层在由干涉滤光层确定的波长范围内具有投射到光阀上的光的透射率。 这种传输不同于在干涉滤光层不彼此光学接触的情况下将发生的透射。