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    Method of drying biological material
    2.
    发明申请
    Method of drying biological material 有权
    生物材料干燥方法

    公开(公告)号：US20080050793A1

    公开(公告)日：2008-02-28

    申请号：US11701096

    申请日：2007-02-01

    Applicant: Timothy Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

    Inventor： Timothy Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

    IPC: C12N13/00

    CPC classification number: C08J9/28 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2301/00 ,  F26B5/048 ,  F26B5/06

    Abstract: A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.

    Abstract translation: 描述了生产含有生物材料的泡沫体的方法。 通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。 允许形成的糊料固化，然后可任选地分配成所需的形状。 可以将糊状物冷冻以允许形成冰晶以充当致孔剂。 随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。 这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。 可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。 通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。 该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

    Method of drying biological material
    4.
    发明授权
    Method of drying biological material 有权
    生物材料干燥方法

    公开(公告)号：US08877469B2

    公开(公告)日：2014-11-04

    申请号：US11701096

    申请日：2007-02-01

    Applicant: Timothy D. Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

    Inventor： Timothy D. Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

    IPC: C12N13/00 ,  F26B5/04 ,  C08J9/28 ,  F26B5/06

    CPC classification number: C08J9/28 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2301/00 ,  F26B5/048 ,  F26B5/06

    Abstract: A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.

    Abstract translation: 描述了生产含有生物材料的泡沫体的方法。 通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。 允许形成的糊料固化，然后可任选地分配成所需的形状。 可以将糊状物冷冻以允许形成冰晶以充当致孔剂。 随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。 这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。 可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。 通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。 该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

    Antimicrobial Composition and Method for Use
    5.
    发明申请
    Antimicrobial Composition and Method for Use 审中-公开
    抗微生物成分及使用方法

    公开(公告)号：US20110014178A1

    公开(公告)日：2011-01-20

    申请号：US12752596

    申请日：2010-04-01

    Applicant: Stephen R. Smith ,  Stewart J. Ritchie ,  Guopeng Zhang

    Inventor： Stephen R. Smith ,  Stewart J. Ritchie ,  Guopeng Zhang

    IPC: A61K35/54 ,  A61K38/47 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12

    CPC classification number: A61K38/47 ,  A23K20/105 ,  A23K20/147 ,  A23K20/189 ,  A23K20/195 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A61K31/198 ,  A61K31/722 ,  A61K35/57 ,  A61K38/164 ,  A61K38/38 ,  A61K38/42 ,  A61K2300/00

    Abstract: An antimicrobial composition and a method for administering the antimicrobial composition through the water or feed of livestock, wherein the antimicrobial composition is made up of lysozyme and various other agents that act synergistically with lysozyme, such as, dried egg powder, albumen, a sequestering agent and/or a lantibiotic. The composition is used to inhibit the growth of, and diseases and epidemiological significant effects caused by, Clostridium perfinigens, E, coli and Salmonella, in the gut of livestock. More particularly, the antimicrobial composition and method relate to a feed additive that can be administered to poultry and/or swine through their feed. The use of such a feed additive may also inhibit other enteric pathogens that may be present in the gut of livestock.

    Abstract translation: 一种抗微生物组合物和通过家禽的水或饲料施用抗微生物组合物的方法，其中抗微生物组合物由溶菌酶和与溶菌酶协同作用的各种其它试剂组成，例如干蛋粉，白蛋白，多价螯合剂 和/或羊毛硫抗生素。 该组合物用于抑制肠道肠道中肠梭菌，大肠杆菌和沙门氏菌引起的生长，疾病和流行病学显着影响。 更具体地，抗微生物组合物和方法涉及可以通过其饲料施用于家禽和/或猪的饲料添加剂。 使用这种饲料添加剂还可以抑制可能存在于牲畜肠道中的其它肠道病原体。

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