公开(公告)号：US20200375580A1

公开(公告)日：2020-12-03

申请号：US16994327

申请日：2020-08-14

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel ORRINGER ,  Christian FREUDIGER ,  Jay TRAUTMAN ,  Andrew KELLY

IPC: A61B10/02 ,  G01J3/44 ,  G01N21/65

Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.

公开(公告)号：US10743848B2

公开(公告)日：2020-08-18

申请号：US15762904

申请日：2016-09-23

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel Orringer ,  Christian Freudiger ,  Jay Trautman ,  Andrew Kelly

IPC: G01J3/44 ,  A61B10/02 ,  G01N21/65 ,  A61B10/04 ,  G01J3/02

Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.

公开(公告)号：US20160238532A1

公开(公告)日：2016-08-18

申请号：US14899536

申请日：2014-06-20

Applicant: INVENIO IMAGING INC.

Inventor： Christian Wilhelm FREUDIGER ,  Jay Kenneth TRAUTMAN

IPC: G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6458 ,  G01N21/6402 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/0826 ,  G02B21/0032 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/16 ,  H01S3/0672 ,  H01S3/06754

Abstract: The present disclosure provides systems and methods for performing multi-photon imaging using a fiber laser. Systems and methods herein may be used for performing imaging using multi-photon excitation (e.g., using two-photon excitation or multi-color two-photon excited fluorescence). Aspects of the disclosure are applicable to a variety of multi-photon methods without being limited to CRS or multi-photon fluorescence excitation. A multi-wavelength fiber laser system and its use in multi-photon methods are provided.

Abstract translation: 本公开提供了使用光纤激光器执行多光子成像的系统和方法。 本文的系统和方法可以用于使用多光子激发（例如，使用双光子激发或多色双光子激发荧光）进行成像。 本公开的方面适用于多种多光子方法，而不限于CRS或多光子荧光激发。 提供了一种多波长光纤激光系统及其在多光子方法中的应用。

公开(公告)号：US20220087532A1

公开(公告)日：2022-03-24

申请号：US17491844

申请日：2021-10-01

Applicant: INVENIO IMAGING, INC.

Inventor： Christian Wilhelm Freudiger ,  Balaji Pandian ,  Jay Trautman

IPC: A61B5/00 ,  G02B21/00 ,  G06T7/00 ,  G06V20/69 ,  G06V10/774 ,  A61K49/00 ,  G06T7/70

Abstract: Systems and methods are described for using a combination of high-resolution, optical-sectioning imaging modalities to provide quantitative measures of the distribution of a contrast agent in tissue samples by identifying its cellular distribution. In some instances, the systems and methods may be used in an intraoperative setting to guide a biopsy or surgical procedure.

公开(公告)号：US11419590B2

公开(公告)日：2022-08-23

申请号：US16994327

申请日：2020-08-14

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel Orringer ,  Christian Freudiger ,  Jay Trautman ,  Andrew Kelly

IPC: G01J3/02 ,  A61B10/02 ,  G01J3/44 ,  G01N21/65 ,  A61B10/04

Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.

公开(公告)号：US20160178439A1

公开(公告)日：2016-06-23

申请号：US14899533

申请日：2014-06-17

Applicant: INVENIO IMAGING INC.

Inventor： Christian Wilhelm FREUDIGER ,  Jay Kenneth TRAUTMAN

IPC: G01J3/44 ,  G01J3/02

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/44 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1447 ,  G01N2021/653 ,  G01N2021/655

Abstract: Systems and methods employing Coherent Raman Scattering (CRS), e.g., Coherent anti-Stokes Raman Spectroscopy (CARS) and/or Stimulated Raman Scattering (SRS) are provided. Systems and methods for performing flow cytometry, imaging and sensing using low-resolution CRS are also provided.

Abstract translation: 提供了使用相干拉曼散射（CRS）的系统和方法，例如相干抗斯托克斯拉曼光谱（CARS）和/或受激拉曼散射（SRS）。 还提供了使用低分辨率CRS进行流式细胞术，成像和感测的系统和方法。

公开(公告)号：US12161486B2

公开(公告)日：2024-12-10

申请号：US17491844

申请日：2021-10-01

Applicant: INVENIO IMAGING, INC.

Inventor： Christian Wilhelm Freudiger ,  Balaji Pandian ,  Jay Trautman

IPC: A61B5/00 ,  A61K49/00 ,  G02B21/00 ,  G06T7/00 ,  G06T7/70 ,  G06V10/42 ,  G06V10/44 ,  G06V10/48 ,  G06V10/762 ,  G06V10/764 ,  G06V10/774 ,  G06V10/82 ,  G06V20/69

Abstract: Systems and methods are described for using a combination of high-resolution, optical-sectioning imaging modalities to provide quantitative measures of the distribution of a contrast agent in tissue samples by identifying its cellular distribution. In some instances, the systems and methods may be used in an intraoperative setting to guide a biopsy or surgical procedure.

公开(公告)号：US20240192120A1

公开(公告)日：2024-06-13

申请号：US18392546

申请日：2023-12-21

Applicant: INVENIO IMAGING, INC.

Inventor： Christian Wilhelm FREUDIGER ,  Steven PASTORE ,  Jay TRAUTMAN

IPC: G01N15/1434 ,  G01N1/38 ,  G01N1/40 ,  G01N15/01 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N1/38 ,  G01N1/4077 ,  G01N15/01 ,  G01N2001/4088 ,  G01N2015/1006

Abstract: The present disclosure provides methods and systems for preparing, imaging, analyzing, and reprocessing biopsy or other cytologic samples for digital imaging. Systems and methods provided herein are directed towards digital imaging of a biological sample that allow for greater efficiency in time by imaging samples of biological analytes adhered to filter paper.

公开(公告)号：US11756675B2

公开(公告)日：2023-09-12

申请号：US16967052

申请日：2019-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel Orringer ,  Balaji Pandian ,  Christian Freudiger ,  Todd Hollon

IPC: G06K9/00 ,  G16H30/40 ,  G01N21/65 ,  G06N3/08 ,  G06T7/00

CPC classification number: G16H30/40 ,  G01N21/65 ,  G06N3/08 ,  G06T7/0012 ,  G01N2021/655 ,  G06T2207/10061 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30016 ,  G06T2207/30096

Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.

公开(公告)号：US20210050094A1

公开(公告)日：2021-02-18

申请号：US16967052

申请日：2019-02-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel ORRINGER ,  Balaji PANDIAN ,  Christian FREUDIGER ,  Todd HOLLON

IPC: G16H30/40 ,  G06T7/00 ,  G01N21/65 ,  G06N3/08

Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.