公开(公告)号：US20050074742A1

公开(公告)日：2005-04-07

申请号：US10473359

申请日：2002-03-29

Applicant: Alain Domard ,  Marie-Therese Corvol ,  Francois Guillot ,  Xavier Chevalier ,  Isabelle Morfin ,  Dominique Vacher

Inventor： Alain Domard ,  Marie-Therese Corvol ,  Francois Guillot ,  Xavier Chevalier ,  Isabelle Morfin ,  Dominique Vacher

IPC: A61K35/12 ,  A61L27/20 ,  A61L27/38 ,  A61L27/52 ,  C12N5/00 ,  C12N5/02 ,  C12N5/077

CPC classification number: A61L27/3817 ,  A61K35/12 ,  A61L27/20 ,  A61L27/3633 ,  A61L27/3654 ,  A61L27/3856 ,  A61L27/52 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/72 ,  C08L5/08

Abstract: A cartilaginous neo-tissue that is capable of being grafted is constituted by rows of approximately parallel cells with a cell maturation gradient orientated from a predetermined zone towards its periphery. During preparation of the cartilaginous neo-tissue with a chitosan hydrogel, the predetermined zone corresponds to the junction of cells with the chitosan hydrogel in contact with which the neo-tissue develops.

Abstract translation: 能够接枝的软骨新组织由具有从预定区域朝向其周边定向的细胞成熟梯度的大致平行细胞行构成。 在用壳聚糖水凝胶制备软骨新组织期间，预定区域对应于与新生组织形成接触的壳聚糖水凝胶的细胞的连接处。