公开(公告)号：US20200262873A1

公开(公告)日：2020-08-20

申请号：US16649889

申请日：2018-09-25

Applicant: JSR CORPORATION ,  JSR Life Sciences Corporation ,  JSR Micro Inc. ,  JSR Micro N.V.

Inventor： Jun-ichi YASUOKA ,  Kiichi YOSHIMURA ,  Tomoaki HAGA

IPC: C07K14/195 ,  C12N5/10 ,  C12N15/63 ,  G01N33/543 ,  C07K1/22 ,  B01J20/24 ,  B01J20/288 ,  B01J20/30 ,  B01D15/38

Abstract: Provided are a protein L-derived immunoglobulin binding protein having an increased antibody dissociation rate under acidic conditions, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.

公开(公告)号：US20200150113A1

公开(公告)日：2020-05-14

申请号：US16473835

申请日：2017-12-27

Applicant: JSR CORPORATION ,  JSR LIFE SCIENCES CORPORATION ,  JSR MICRO INC. ,  JSR MICRO N.V.

Inventor： Kazusa OOTA

IPC: G01N33/543 ,  C08C1/065 ,  C08F2/22

Abstract: To provide a novel technique with which the generation of aggregates over time in a dispersion liquid can be suppressed and a target substance can be detected with high sensitivity even if latex particles that have been stored are used. A method for storing in a container a latex particle dispersion liquid in which latex particles for an extracorporeal diagnostic agent are dispersed, the latex particles having a volume average particle size of 10 to 1000 nm and including a polymer containing 70 to 100% by mass of monomer units each derived from a monomer having an aryl group relative to the total monomer units, which is characterized in that the particle dispersion liquid is stored in the container by setting a ratio of a volume of a void space obtained by excluding a volume occupied by the particle dispersion liquid from an internal volume of the container to 0 to 25% (v/v) relative to the internal volume of the container.

公开(公告)号：US20190271696A1

公开(公告)日：2019-09-05

申请号：US16348996

申请日：2017-12-27

Applicant: JSR CORPORATION ,  JSR LIFE SCIENCES CORPORATION ,  JSR Micro, Inc. ,  JSR Micro N.V.

Inventor： Hirokazu KAI ,  Kousuke HIROKI ,  Yuuichi UEYA

IPC: G01N33/553 ,  C07D275/03 ,  C07D275/04

Abstract: The present invention relates to a magnetic particle dispersion, and the magnetic particle dispersion includes a magnetic particle, an isothiazoline compound, and an aqueous medium.

公开(公告)号：US20210163545A1

公开(公告)日：2021-06-03

申请号：US16649879

申请日：2018-09-25

Applicant: JSR CORPORATION ,  JSR Life Sciences Corporation ,  JSR Micro Inc. ,  JSR Micro N. V.

Inventor： Jun-ichi YASUOKA ,  Kiichi YOSHIMURA

IPC: C07K14/195 ,  C07K1/22 ,  C07K14/00 ,  C12P21/02

Abstract: Provided are a protein L-derived immunoglobulin binding protein having an increased alkali tolerance, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.

公开(公告)号：US20180284109A1

公开(公告)日：2018-10-04

申请号：US15936807

申请日：2018-03-27

Applicant: JSR CORPORATION ,  JSR LIFE SCIENCES CORPORATION ,  JSR Micro, Inc. ,  JSR Micro N.V.

Inventor： Yuuichi Ueya ,  Yasuhito Satou

IPC: G01N33/543 ,  G01N33/53 ,  B03C1/01

Abstract: This invention relates to a method of producing a probe-bound carrier, a probe-bound carrier and a method of detecting or separating a target substance. The method of producing a probe-bound carrier includes: step 1 of mixing a carrier having tosyl groups and a probe; and step 2 of reducing the amount of tosyl groups on a surface of a carrier, in which a proportion of area S2 that is occupied by one tosyl group on a surface of the carrier obtained in the step 2 with respect to area S1A that is occupied by one tosyl group on a surface of the carrier used in the step 1 (S2/S1A×100%) is not less than 140%.

公开(公告)号：US20040229453A1

公开(公告)日：2004-11-18

申请号：US10439415

申请日：2003-05-15

Applicant: JSR Micro, Inc.

Inventor： Dung-Ching Perng

IPC: H01L023/48

CPC classification number: H01L21/76843 ,  H01L21/76852 ,  H01L21/76855 ,  H01L21/76858 ,  H01L21/76868 ,  H01L21/76885

Abstract: One method includes porous low k pore sealing that uses a combination of materials that bond and expand, thereby covering any pore or irregularities in the surface of an insulator adjacent to a conductor. The materials form a substantially impermeable barrier between the conductor and insulator that prevents leakage of the conductor into the insulator. Another method encapsulates the conductor on all exposed surfaces with an impermeable barrier before placement of an insulator, thereby preventing both anode extrusion and diffusion via pores in the insulator.

Abstract translation: 一种方法包括使用结合和膨胀的材料的组合的多孔低k孔密封，从而覆盖邻近导体的绝缘体的表面中的任何孔或不规则。 该材料在导体和绝缘体之间形成基本不可渗透的阻挡层，防止导体泄漏到绝缘体中。 另一种方法是在放置绝缘体之前将导体封装在具有不透水屏障的所有暴露表面上，从而防止阳极挤出和扩散通过绝缘体中的孔。

公开(公告)号：US20210179671A1

公开(公告)日：2021-06-17

申请号：US17268804

申请日：2019-08-23

Applicant: JSR CORPORATION ,  JSR MICRO INC. ,  JSR MICRO N.V.

Inventor： Tomoaki HAGA ,  Takashi ICHII ,  Shunsuke ONOGI ,  Satoshi NAKAMURA ,  Toshinari HONDA ,  Tomoyuki KAMIDE

IPC: C07K14/31 ,  C07K16/00 ,  C07K1/22 ,  B01D15/38

Abstract: An affinity carrier may have improved alkali resistance. An immunoglobulin-binding protein containing a mutant polypeptide chain, as well as an affinity carrier containing a solid-phase carrier to which the immunoglobulin-binding protein is bound, may be a mutant polypeptide chain having an amino acid sequence having at least 85% identity to an amino acid sequence indicated by any of SEQ ID NO: 1-6 and 57-62, having a predetermined mutation, and having immunoglobulin-binding activity.

公开(公告)号：US20200319171A1

公开(公告)日：2020-10-08

申请号：US16303941

申请日：2017-05-23

Applicant: JSR Corporation ,  JSR Micro, Inc.

Inventor： Takeaki MASUDA ,  Shunsuke Onogi

IPC: G01N33/545 ,  G01N33/543 ,  G01N33/553

Abstract: The present invention relates to composite particles, coated particles, a method of producing composite particles, a ligand-containing solid phase carrier, and a method of detecting or separating a target substance in a sample. The above described composite particles each contains an organic polymer and inorganic nanoparticles, wherein the content of the inorganic nanoparticles in the composite particles is more than 80% by mass, and wherein the composite particles have a volume average particle size of from 10 to 1,000 nm.