公开(公告)号：US06800369B2

公开(公告)日：2004-10-05

申请号：US10037045

申请日：2001-11-09

Applicant: James Gimzewski ,  Reto Schlittler ,  Jin Won Seo

Inventor： James Gimzewski ,  Reto Schlittler ,  Jin Won Seo

IPC: B32B108

CPC classification number: C30B23/005 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/02 ,  C30B1/00 ,  C30B23/00 ,  C30B29/02 ,  C30B29/605 ,  Y10S977/75 ,  Y10S977/843 ,  Y10S977/844 ,  Y10T428/13 ,  Y10T428/30 ,  Y10T428/31663

Abstract: The invention is directed to a method of manufacturing single-walled carbon nanotubes comprising the steps of providing on a substrate at least one pillar comprising alternate layers of a first precursor material comprising fullerene molecules and a second precursor material comprising a catalyst, and heating the at least one pillar in the presence of a first magnetic or electric field. It further is directed to a precursor arrangement for manufacturing single-walled carbon nanotubes comprising on a substrate at least one pillar comprising alternate layers of a first precursor material comprising fullerene molecules and a second precursor material comprising a catalyst. A third aspect is a nanotube arrangement comprising a substrate and thereupon at least one crystal comprising a bundle of single-walled carbon nanotubes with essentially identical orientation and structure.

Abstract translation: 本发明涉及一种制造单壁碳纳米管的方法，包括以下步骤：在基材上提供至少一个柱，该柱包括包含富勒烯分子的第一前体材料和包含催化剂的第二前体材料的交替层， 在第一磁场或电场的存在下至少有一个支柱。 本发明还涉及用于制造单壁碳纳米管的前体装置，其包括在至少一个支柱上的至少一个柱，所述至少一个柱包括包含富勒烯分子的第一前体材料的交替层和包含催化剂的第二前体材料。 第三方面是纳米管布置，其包括基底，并且随后至少一个晶体包括具有基本上相同取向和结构的单层碳纳米管束。

公开(公告)号：US08396181B2

公开(公告)日：2013-03-12

申请号：US11745556

申请日：2007-05-08

Applicant: Brian Naranjo ,  James Gimzewski ,  Seth Putterman

Inventor： Brian Naranjo ,  James Gimzewski ,  Seth Putterman

IPC: G21G4/02

CPC classification number: G21B3/00 ,  G21B3/006 ,  Y02E30/18

Abstract: Gently heating a pyroelectric crystal in a deuterated atmosphere can generate fusion under desktop conditions. The electrostatic field of the crystal is used to generate and accelerate a deuteron beam (>100 keV and >4 nA), which, upon striking a deuterated target, produces a neutron flux over 400 times the background level. The presence of neutrons within the target is confirmed by pulse shape analysis and proton recoil spectroscopy. Several elements of the system may be modified, including the configuration of the crystal or crystals, the composition of the surrounding environment and the target, the use of multiple probe tips, and the composition of the probe tip.

Abstract translation: 在氘化气氛下轻轻加热热电晶体可在桌面条件下产生融合。 晶体的静电场用于产生和加速氘核束（> 100keV和> 4nA），其在击氘氘化靶时产生超过400倍背景水平的中子通量。 通过脉冲形状分析和质子反冲光谱法确认靶内存在的中子。 可以修改系统的几个元件，包括晶体或晶体的配置，周围环境和靶的组成，多个探针尖端的使用以及探针尖端的组成。

公开(公告)号：US07560070B1

公开(公告)日：2009-07-14

申请号：US10129254

申请日：2000-10-16

Applicant: Marko K. Baller ,  Juergen Fritz ,  Christoph Gerber ,  James Gimzewski ,  Hans Peter Lang

Inventor： Marko K. Baller ,  Juergen Fritz ,  Christoph Gerber ,  James Gimzewski ,  Hans Peter Lang

IPC: G01N33/00

CPC classification number: G01N33/54373 ,  Y10T436/11

Abstract: Sensor system (70) for detecting a target substance in a reference liquid, comprising a measurement cantilever (71) being functionalized by application of a first coating to one of the measurement cantilever's surfaces, whereby this first coating is sensitive to the target substance. In addition, the system (70) comprises a reference cantilever (72) with a reference coating on one of the reference cantilever's surfaces, whereby this reference coating is less sensitive to the target substance than the first coating. Both cantilevers are arranged such that they can be exposed in a reference step to the reference liquid and in a detection step to the reference liquid with the target substance. A detector unit (73, 74, 83) is employed for determining the difference in the deflection of the measurement cantilever (71) and the reference cantilever (72) during the reference step and the detection step.

Abstract translation: 用于检测参考液体中的目标物质的传感器系统（70），包括通过向测量悬臂表面之一施加第一涂层而被功能化的测量悬臂（71），由此该第一涂层对目标物质敏感。 此外，系统（70）包括在参考悬臂表面之一上具有参考涂层的参考悬臂（72），由此该参考涂层比第一涂层对目标物质的敏感性较低。 两个悬臂布置成使得它们可以在参考步骤中暴露于参考液体，并且在用目标物质进行参考液体的检测步骤中。 采用检测器单元（73,74,83）来确定参考步骤和检测步骤期间测量悬臂（71）和参考悬臂（72）的偏转差。

公开(公告)号：US20080142717A1

公开(公告)日：2008-06-19

申请号：US11745556

申请日：2007-05-08

Applicant: Brian Naranjo ,  James Gimzewski ,  Seth Putterman

Inventor： Brian Naranjo ,  James Gimzewski ,  Seth Putterman

IPC: G01J5/02

CPC classification number: G21B3/00 ,  G21B3/006 ,  Y02E30/18

Abstract: Gently heating a pyroelectric crystal in a deuterated atmosphere can generate fusion under desktop conditions. The electrostatic field of the crystal is used to generate and accelerate a deuteron beam (>100 keV and >4 nA), which, upon striking a deuterated target, produces a neutron flux over 400 times the background level. The presence of neutrons within the target is confirmed by pulse shape analysis and proton recoil spectroscopy. Several elements of the system may be modified, including the configuration of the crystal or crystals, the composition of the surrounding environment and the target, the use of multiple probe tips, and the composition of the probe tip.

Abstract translation: 在氘化气氛下轻轻加热热电晶体可在桌面条件下产生融合。 晶体的静电场用于产生和加速氘核束（> 100keV和> 4nA），其在击氘氘化靶时产生超过400倍背景水平的中子通量。 通过脉冲形状分析和质子反冲光谱法确认靶内存在的中子。 可以修改系统的几个元件，包括晶体或晶体的配置，周围环境和靶的组成，多个探针尖端的使用以及探针尖端的组成。

公开(公告)号：US20070092905A1

公开(公告)日：2007-04-26

申请号：US11582938

申请日：2006-10-17

Applicant: James Gimzewski ,  Bhubaneswar Mishra ,  Jason Reed

Inventor： James Gimzewski ,  Bhubaneswar Mishra ,  Jason Reed

IPC: C12Q1/68 ,  G06F19/00 ,  C12M1/34 ,  C12M3/00

CPC classification number: C12Q1/6834 ,  C12Q1/683 ,  C12Q2565/601 ,  C12Q2565/518 ,  C12Q2521/331 ,  C12Q2522/101

Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

Abstract translation: 本发明提供了检测样品中核酸分析物的方法。 所述方法通常包括将固定化的核酸从样品修改为基本上细长的构型的不溶性支持物，其中修饰产生识别分析物的识别特征; 并使用扫描探针显微镜检测识别特征，以检测分析物。 本发明还提供了将特征的轮廓分配给核酸的方法。 本发明还提供一种用于本发明方法的计算机程序产品。 本发明还提供了一种用于检测样品中核酸的系统; 以及用于将特征的轮廓分配给核酸的系统。 本发明还提供了将核酸固定在不溶性载体上的方法; 并进一步提供其上固定有核酸的不溶性载体。 本发明还提供了诊断个体中的病症或病症的方法，其中所述方法涉及使用本发明的方法来检测核酸分析物。

公开(公告)号：US20070089516A1

公开(公告)日：2007-04-26

申请号：US11543550

申请日：2006-10-04

Applicant: Butrus Khuri-Yakub ,  Calvin Quate ,  James Gimzewski

Inventor： Butrus Khuri-Yakub ,  Calvin Quate ,  James Gimzewski

IPC: G01H13/00

CPC classification number: G01N27/221 ,  G01N1/26 ,  G01N2001/022 ,  G01N2291/02863 ,  G01N2291/0427

Abstract: The present invention provides sensors based on micromachined ultrasonic transducer technology. The sensors preferably include a plurality of sensor elements, but may include only one sensor element. Arrays of sensors are also provided. Sensor elements include a functionalized membrane supported over a substrate by a support frame. The functionalized membrane, support frame and substrate together form a vacuum gap. The sensor element is connected to an electrical circuit, which is configured to operate the sensor element at or near an open circuit resonance condition. The mechanical resonance frequency of the functionalized membrane is responsive to binding of an agent to the membrane. Thus, the sensor element also includes a detector, where the detector provides a sensor output responsive to the mechanical resonance frequency of the sensor element.

公开(公告)号：US20130266665A1

公开(公告)日：2013-10-10

申请号：US13802080

申请日：2013-03-13

Applicant: Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

Inventor： Oliver DORIG ,  James Gimzewski ,  Jianyu Rao ,  Shivani Sharma ,  Chintda Santiskulvong

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N2800/52 ,  G01Q60/366

Abstract: A method of treating a patient having cancer includes: (1) providing a biological sample from the patient, the biological sample including multiple cells; (2) detecting a response of the biological sample to a probing element; (3) based on the response, determining test values for the biological sample, the test values being indicative of a nanomechanical characteristic of the cells; (4) deriving a test nanomechanical profile characterizing a distribution of the test values; and (5) based on the test nanomechanical profile, selecting a therapeutic agent to treat the patient.

Abstract translation: 治疗患有癌症的患者的方法包括：（1）从患者提供生物样品，所述生物样品包括多个细胞; （2）检测生物样品对探测元件的响应; （3）基于响应，确定生物样品的测试值，测试值表示细胞的纳米机械特征; （4）导出表征测试值分布的测试纳米机械轮廓; 和（5）基于测试纳米机械特征，选择治疗剂治疗患者。

公开(公告)号：US20070189920A1

公开(公告)日：2007-08-16

申请号：US10589430

申请日：2005-04-14

Applicant: James Gimzewski

Inventor： James Gimzewski

IPC: G01N25/20

CPC classification number: G01N25/20 ,  G01K1/16 ,  G01K17/00

Abstract: The present invention provides a calorimeter device, generally comprising a reaction vessel which may be U-shaped and which may be cantilevered; and a sensor for detecting temperature changes. In various embodiments, the sensor detects heat input into or output from the reaction vessel; changes in the electrical properties of a material coated onto the reaction vessel; changes in the mechanical properties of the reaction vessel; or changes in the resonance properties of the reaction vessel. The present invention further provides arrays of a subject calorimeter device. The present invention further provides a system for detecting a temperature change. The present invention further provides methods of detecting a temperature change that occurs as a result of a chemical, biochemical, biological, light-induced, or physical process. The methods generally involve introducing a sample into a subject device, and detecting a temperature change.

Abstract translation: 本发明提供了一种热量计装置，其通常包括可以是U形并且可以悬臂的反应容器; 以及用于检测温度变化的传感器。 在各种实施例中，传感器检测进入或从反应容器输出的热量; 涂覆在反应容器上的材料的电性能的变化; 反应容器机械性能的变化; 或反应容器的共振特性的变化。 本发明还提供一种主题量热仪装置的阵列。 本发明还提供一种用于检测温度变化的系统。 本发明还提供了检测作为化学，生物化学，生物学，光诱导或物理过程的结果而发生的温度变化的方法。 所述方法通常涉及将样品引入到本体装置中并检测温度变化。

公开(公告)号：US20050239047A1

公开(公告)日：2005-10-27

申请号：US11077266

申请日：2005-03-09

Applicant: James Gimzewski ,  Andrew Pelling

Inventor： James Gimzewski ,  Andrew Pelling

IPC: C12M1/34 ,  C12Q1/00 ,  G01N33/48 ,  G01N33/50 ,  G01Q20/00 ,  G01Q30/02 ,  G01Q60/00 ,  G06F19/00

CPC classification number: G01N33/5088 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5076 ,  G01N33/5091 ,  G01Q20/02 ,  G01Q60/24 ,  Y02A90/26

Abstract: The present invention provides methods of determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, and biological state. The method generally involves detecting membrane movement in a cell to determine a characteristic of a cell. The methods of the invention are useful for applications such as drug screening and diagnostics. The invention further provides databases of cell characteristics, as determined by the instant methods. The invention further provides systems for determining the characteristic of a cell

Abstract translation: 本发明提供了确定细胞特征的方法，例如细胞类型，对生物化学事件的细胞反应和生物学状态。 该方法通常涉及检测细胞中的膜运动以确定细胞的特征。 本发明的方法对于诸如药物筛选和诊断的应用是有用的。 本发明还提供了通过本方法确定的小区特征的数据库。 本发明还提供用于确定电池特性的系统

公开(公告)号：US5547774A

公开(公告)日：1996-08-20

申请号：US114895

申请日：1993-09-01

Applicant: James Gimzewski ,  Michele Parrinello ,  Bruno Reihl

Inventor： James Gimzewski ,  Michele Parrinello ,  Bruno Reihl

IPC: G01Q20/00 ,  G11B9/00 ,  G11B5/66

CPC classification number: B82Y10/00 ,  G11B9/14 ,  G11B9/149 ,  G11C13/025 ,  Y10S430/146 ,  Y10S977/858 ,  Y10S977/947

Abstract: A recording and reproducing method for binary coded information and a suitable recording medium are described, which use endohedrally doped cagelike molecules 30, especially fullerenes and derivatives thereof, as storage elements. By applying a probing tip 36 to the molecule for the read/write process an enhanced storage density is achieved.

Abstract translation: 描述了用于二进制编码信息和合适的记录介质的记录和再现方法，其使用内向掺杂的笼状分子30，特别是富勒烯及其衍生物作为存储元件。 通过将探测尖端36应用于读/写处理的分子，实现增强的存储密度。