公开(公告)号：US20050048185A1

公开(公告)日：2005-03-03

申请号：US10824977

申请日：2004-04-14

Applicant: Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

Inventor： Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

IPC: A23L29/20 ,  A61K8/02 ,  A61K8/04 ,  A61K8/73 ,  A61Q19/00 ,  A23L1/05

CPC classification number: A61K8/042 ,  A61K8/0208 ,  A61K8/737 ,  A61Q19/00

Abstract: Abstract of the Disclosure The present invention is directed to a delivery system comprising a homogeneous, thermoreversible gel film, wherein the gel film comprises: (i) a film forming amount of low viscosity polymannan gum, e.g., low viscosity guar gum, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and (ii) an active substance. The present invention is also directed to a process for the manufacture thereof.

Abstract translation: 发明内容本发明涉及包含均质的热可逆凝胶膜的递送系统，其中凝胶膜包括：（i）成膜量低的聚甘露糖，例如低粘度瓜尔胶，并且任选地 至少一种增塑剂，第二成膜剂，填充剂和pH控制剂; 和（ii）活性物质。 本发明还涉及其制造方法。

公开(公告)号：US20050084516A1

公开(公告)日：2005-04-21

申请号：US10824689

申请日：2004-04-14

Applicant: Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

Inventor： Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: Abstract of the Disclosure The present invention is directed to a process for making homogeneous, thermoreversible gel films comprising the steps of: (i) heating, hydrating, mixing, solubilizing, and, optionally, de-aerating a high solids, low moisture film forming composition in an apparatus providing sufficient shear, temperature and residence time to form a homogeneous molten composition, wherein the temperature is at or above the solubilizing temperature of said composition; (ii) feeding the molten composition into at least one of a mixer, pump or devolatilizer; and (iii) cooling the homogeneous molten composition at or below its gelling temperature to form said gel films. The present invention is also directed to various products made from such films, such as the gel films themselves, soft capsules, solid dosage forms and delivery systems.

Abstract translation: 发明内容本发明涉及一种制备均匀的热可逆凝胶膜的方法，包括以下步骤：（i）加热，水合，混合，增溶和任选地使高固体，低水分成膜 在提供足够的剪切，温度和停留时间以形成均匀的熔融组合物的装置中的组合物，其中所述温度等于或高于所述组合物的溶解温度; （ii）将熔融组合物进料到混合器，泵或脱挥器中的至少一个中; 和（iii）在等于或低于其凝胶化温度下冷却均匀的熔融组合物以形成所述凝胶膜。 本发明还涉及由这样的膜制成的各种产品，例如凝胶膜本身，软胶囊，固体剂型和递送系统。

公开(公告)号：US20050019295A1

公开(公告)日：2005-01-27

申请号：US10824956

申请日：2004-04-14

Applicant: Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

Inventor： Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

IPC: A61K8/02 ,  A61K8/04 ,  A61K8/73 ,  A61K9/48 ,  A61Q19/00 ,  A61K7/06 ,  A61K7/11

CPC classification number: A61K8/0208 ,  A61K8/042 ,  A61K8/737 ,  A61Q19/00

Abstract: Abstract of the Disclosure The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of low viscosity polymannan gum, e.g., low viscosity guar gum, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 发明内容本发明涉及均匀的热可逆凝胶膜，其包含成膜量低的聚甘露糖胶，例如低粘度瓜尔胶，以及任选的至少一种增塑剂，第二成膜剂，膨胀 药剂和pH控制剂; 及其制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。

公开(公告)号：US20060096500A1

公开(公告)日：2006-05-11

申请号：US10513530

申请日：2003-05-14

Applicant: Domingo Tuason ,  Jose Amundarain ,  Gregory Krawczyk ,  Edward Selinger ,  William Blakemore ,  James Modliszewski ,  Joseph Lee ,  Frank Messick

Inventor： Domingo Tuason ,  Jose Amundarain ,  Gregory Krawczyk ,  Edward Selinger ,  William Blakemore ,  James Modliszewski ,  Joseph Lee ,  Frank Messick

IPC: C09D103/00

CPC classification number: A23L1/0534 ,  A01N25/10 ,  A23C9/137 ,  A23G1/56 ,  A23G3/346 ,  A23G2200/06 ,  A23L2/52 ,  A23L19/09 ,  A23L29/256 ,  A23L29/262 ,  A23V2002/00 ,  A61K8/02 ,  A61K8/73 ,  A61K8/731 ,  A61K8/733 ,  A61K9/146 ,  A61K47/36 ,  A61K47/38 ,  A61K2800/412 ,  A61K2800/594 ,  A61Q5/00 ,  A61Q19/00 ,  C08B15/02 ,  C08J3/12 ,  C08J3/128 ,  C08J2301/04 ,  C08J2305/04 ,  C08K3/16 ,  C08L1/02 ,  C08L1/04 ,  C08L5/00 ,  C08L5/04 ,  C08L5/06 ,  C08L2205/02 ,  C08L2666/26 ,  A23V2250/50364 ,  A23V2250/51084 ,  A23V2200/254 ,  A23V2250/50362 ,  A23V2250/50722 ,  A23V2250/5086 ,  A23V2250/1578 ,  A23V2250/5026 ,  A23V2250/5118

Abstract: Ultra-fine microcrystalline cellulose compositions are disclosed which comprise co-attrited microcrystalline cellulose and a hydrocolloid. The compositions have a mean particle size of less thin 10 microns. The compositions are prepared by subjecting a high solids mixture of microcrystalline cellulose and a hydrocolloid to high shear forces in the presence of an anti slip agent preferably an aqueoussolution of an inorganic salt. The compositions arc especially useful in food pharmaceutical and cosmedic and industrial applications.

Abstract translation: 公开了包含共磨微晶纤维素和水胶体的超细微晶纤维素组合物。 组合物具有较薄的10微米的平均粒度。 通过在防滑剂，优选无机盐水溶液的存在下，将微晶纤维素和水胶体的高固体混合物进行高剪切力制备组合物。 该组合物特别适用于食品药物和卫生和工业应用。

公开(公告)号：US20050171053A1

公开(公告)日：2005-08-04

申请号：US10976975

申请日：2004-10-29

Applicant: William Blakemore ,  Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Bubnis

Inventor： William Blakemore ,  Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Bubnis

IPC: A01N59/16 ,  A61K31/57 ,  A61K31/715 ,  A61K31/731 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  C08B37/00 ,  C08L5/00 ,  C08L5/12 ,  C07H13/12

CPC classification number: C08L5/00 ,  A01N59/16 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/57 ,  A61K31/715 ,  A61K31/731 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  C08B37/0042 ,  C08L5/12 ,  A61K2300/00 ,  A01N25/10 ,  A01N2300/00

Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more carrageenans, including lambda carrageenan. Also disclosed are methods for making and using the compositions.

公开(公告)号：US20050008677A1

公开(公告)日：2005-01-13

申请号：US10824793

申请日：2004-04-14

Applicant: James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

Inventor： James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

IPC: A23L1/00 ,  A23L1/0532 ,  A23L1/22 ,  A23L1/30 ,  A61K8/02 ,  A61K8/04 ,  A61K8/73 ,  A61K47/00 ,  A61Q11/00 ,  A61Q19/00

CPC classification number: A61K8/0208 ,  A23L27/79 ,  A23L29/256 ,  A23L33/10 ,  A23P20/20 ,  A23V2002/00 ,  A61K8/042 ,  A61K8/73 ,  A61Q11/00 ,  A61Q19/00 ,  A23V2250/50364 ,  A23V2250/506 ,  A23V2250/5114 ,  A23V2250/6406 ,  A23V2250/2108 ,  A23V2250/5118

Abstract: Abstract of the Disclosure The present invention is directed to a delivery system comprising a homogenous, thermoreversible gel film, wherein the gel film comprises: (i) a film forming amount of kappa-2 carrageenan and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and (ii) an active substance. The present invention is also directed to a process for the manufacture thereof.

Abstract translation: 发明内容本发明涉及一种包含均质的热可逆凝胶膜的递送系统，其中所述凝胶膜包括：（i）成膜量的κ-2角叉菜胶和任选的至少一种增塑剂，第二 成膜剂，填充剂和pH控制剂; 和（ii）活性物质。 本发明还涉及其制造方法。

公开(公告)号：US20080089934A1

公开(公告)日：2008-04-17

申请号：US11954958

申请日：2007-12-12

Applicant: Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

Inventor： Arthur Ballard ,  Christopher Sewall ,  James Modliszewski ,  William Blakemore ,  Peter Riley

IPC: A61K9/48 ,  B01J13/02 ,  C08L1/00 ,  C08L3/00 ,  C08L5/00

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: The present invention is directed to a process for making homogeneous, thermoreversible gel films comprising the steps of: (i) heating, hydrating, mixing, solubilizing, and, optionally, de-aerating a high solids, low moisture film forming composition in an apparatus providing sufficient shear, temperature and residence time to form a homogeneous molten composition, wherein the temperature is at or above the solubilizing temperature of said composition; (ii) feeding the molten composition into at least one of a mixer, pump or devolatilizer; and (iii) cooling the homogeneous molten composition at or below its gelling temperature to form said gel films. The present invention is also directed to various products made from such films, such as the gel films themselves, soft capsules, solid dosage forms and delivery systems.

Abstract translation: 本发明涉及一种制备均匀的热可逆凝胶膜的方法，包括以下步骤：（i）在装置中加热，水合，混合，增溶和任选地使高固体，低水分成膜组合物脱气 提供足够的剪切，温度和停留时间以形成均匀的熔融组合物，其中温度等于或高于所述组合物的溶解温度; （ii）将熔融组合物进料到混合器，泵或脱挥器中的至少一个中; 和（iii）在等于或低于其凝胶化温度下冷却均匀的熔融组合物以形成所述凝胶膜。 本发明还涉及由这样的膜制成的各种产品，例如凝胶膜本身，软胶囊，固体剂型和递送系统。

公开(公告)号：US20070281065A1

公开(公告)日：2007-12-06

申请号：US11810661

申请日：2007-06-06

Applicant: James Modliszewski ,  Robert Kopesky ,  Christopher Sewall

Inventor： James Modliszewski ,  Robert Kopesky ,  Christopher Sewall

IPC: A23L1/05

CPC classification number: A23L27/72 ,  A23L29/256 ,  A23P10/30

Abstract: The present invention is directed to a kappa-2 carrageenan composition comprising: (i) kappa-2 carrageenan, (ii) at least 70% sodium by weight of all cations in the composition; and (iii) free salt present in an amount of 0-25% by weight of the composition; wherein the composition has a viscosity of 20 cps to 40 cps. The present invention is also directed to products made from such kappa-2 carrageenan composition, as well as to processes of manufacture and use thereof.

Abstract translation: 本发明涉及一种卡帕-2角叉菜胶组合物，其包含：（i）κ-2角叉菜胶，（ii）所述组合物中所有阳离子的至少70重量％的钠; 和（iii）以组合物的0-25重量％的量存在的游离盐; 其中所述组合物的粘度为20cps至40cps。 本发明还涉及由这种κ-2角叉菜胶组合物制备的产品，以及其制备和使用方法。

公开(公告)号：US20050019374A1

公开(公告)日：2005-01-27

申请号：US10824860

申请日：2004-04-14

Applicant: James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

Inventor： James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

IPC: A01N43/04 ,  A61K20060101 ,  A61K8/11 ,  A61K8/73 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/715 ,  A61K31/737 ,  A61K47/00 ,  A61Q19/00 ,  A61Q90/00 ,  B01F5/02

CPC classification number: A61K31/715 ,  A23L29/238 ,  A61K8/042 ,  A61K8/11 ,  A61K8/73 ,  A61K8/737 ,  A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/36 ,  A61Q11/00 ,  A61Q19/00

Abstract: Abstract of the Disclosure The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of kappa-2 carrageenan, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 发明内容本发明涉及一种均匀的热可逆凝胶膜，其包含成膜量的κ-2角叉菜胶，以及任选的增塑剂，第二成膜剂，填充剂和pH控制剂中的至少一种 ; 及其制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。

公开(公告)号：US20050019294A1

公开(公告)日：2005-01-27

申请号：US10824919

申请日：2004-04-14

Applicant: James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

Inventor： James Modliszewski ,  Arthur Ballard ,  Christopher Sewall ,  William Blakemore ,  Peter Riley

IPC: A61K8/02 ,  A61K8/04 ,  A61K8/73 ,  A61K9/48 ,  A61Q19/00 ,  A61K7/06 ,  A61K7/11

CPC classification number: A61K8/0208 ,  A61K8/042 ,  A61K8/733 ,  A61Q19/00

Abstract: Abstract of the Disclosure The present invention is directed to a homogeneous, thermoreversible gel film comprising a film forming amount of a water soluble, thermoreversible alginate, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and processes for the preparation thereof. The present invention is also directed to soft capsules and solid forms containing the gel film, as well as processes for the preparation thereof.

Abstract translation: 发明内容本发明涉及均匀的热可逆凝胶膜，其包含成膜量的水溶性热可逆藻酸盐，以及任选的增塑剂，第二成膜剂，填充剂和pH中的至少一种 控制剂; 及其制备方法。 本发明还涉及含有凝胶膜的软胶囊和固体形式，以及其制备方法。