公开(公告)号：US06391591B1

公开(公告)日：2002-05-21

申请号：US09624982

申请日：2000-07-25

Applicant: Michael Petersen ,  Klaus Heinzmann

Inventor： Michael Petersen ,  Klaus Heinzmann

IPC: C12P1926

CPC classification number: C12P19/26

Abstract: Novel microorganisms, which can be obtained by the following selection method: (a) microorganisms which grow using N-acetylglucosamine as the sole carbon source are cultivated in a customary manner, (b) from the resulting culture, these microorganisms are then selected which are stable and have the property to metabolize N-acetylglucosamine rapidly in the presence of N-Acetylmannosamine. Furthermore, a novel process for preparing NAM starting from a mixture of NAM and NAG.

Abstract translation: 可以通过以下选择方法获得的新型微生物：（a）以N-乙酰葡糖胺为唯一碳源生长的微生物以常规方式培养，（b）从得到的培养物中，选择这些微生物 具有在N-乙酰甘露糖胺存在下快速代谢N-乙酰氨基葡萄糖的性质。此外，还提供了一种从NAM和NAG混合物制备NAM的新方法。

公开(公告)号：US5306630A

公开(公告)日：1994-04-26

申请号：US24768

申请日：1993-03-02

Applicant: Andreas Kiener ,  Andreas Tschech ,  Andreas Tinschert ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Andreas Tschech ,  Andreas Tinschert ,  Klaus Heinzmann

IPC: C07D213/80 ,  C07D239/34 ,  C07D241/08 ,  C07D241/14 ,  C07D241/24 ,  C12N1/20 ,  C12P7/02 ,  C12P7/40 ,  C12P17/12 ,  C12R1/01 ,  C12N1/12 ,  C12P7/42

CPC classification number: C07D213/80 ,  C07D241/24 ,  C12P17/12 ,  C12R1/01 ,  Y10S435/822

Abstract: A new microbiological process for the production of hydroxy-nitrogen-heterocyclic-carboxylic acids or their soluble salts of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl group and X is a nitrogen atom or a CR.sub.3 function, wherein R.sub.3 is a hydrogen atom or a halogen atom, starting from the corresponding nitrogen-heterocyclic-carboxylic acids, as well as new microorganisms suitable for use in the process.

Abstract translation: 用于生产羟基 - 氮杂环羧酸或其可溶性盐的新的微生物方法，其通式为：（*化学结构*）I，其中R 1和R 2相同或不同，各自为氢原子，卤素 原子或C 1 -C 4烷基，X为氮原子或CR 3官能团，其中R3为氢原子或卤素原子，起始于相应的氮杂环羧酸，以及适用于 的过程。

公开(公告)号：US5238830A

公开(公告)日：1993-08-24

申请号：US861306

申请日：1992-03-31

Applicant: Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

IPC: C12P17/12

CPC classification number: C12R1/05 ,  C12P17/12 ,  Y10S435/822 ,  Y10S435/829 ,  Y10S435/874

Abstract: A microbiological process for the production of 6-hydroxypicolinic acid starting from picolinic acid and/or its salts. The concentration of picolinic acid and/or its salts is selected so that the 6-hydroxypicolinic acid is not further metabolized. The process is performed either by microorganisms of genus Pseudomonas, Bacillus, Alcalioenes, Aerococcus, or Rhodotorula, or with biomass using picolinic acid, which grow with picolinic acid as the sole carbon, nitrogen and energy source.

Abstract translation: 从吡啶甲酸和/或其盐开始生产6-羟基吡啶甲酸的微生物过程。 选择吡啶甲酸和/或其盐的浓度使得6-羟基吡啶甲酸不被进一步代谢。 该方法由假单胞菌属，芽孢杆菌属，阿尔卡尼氏菌属，Aerococcus属或红酵母属的微生物进行，或者使用与吡啶甲酸作为唯一碳，氮和能源一起生长的吡啶甲酸的生物质。

公开(公告)号：US5182197A

公开(公告)日：1993-01-26

申请号：US830844

申请日：1992-02-04

Applicant: Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

IPC: C12P7/42 ,  C12N1/20 ,  C12P17/10 ,  C12P17/12 ,  C12R1/01 ,  C12R1/05 ,  C12R1/07 ,  C12R1/38

CPC classification number: C12R1/05 ,  C12P17/12 ,  Y10S435/822 ,  Y10S435/829 ,  Y10S435/874

Abstract: A microbiological process for the production of 6-hydroxypicolinic acid starting from picolinic acid and/or its salts. The concentration of picolinic acid and/or its salts is selected so that the 6-hydroxypicolinic acid is not further metabolized. The process is performed either by microorganisms of genus Pseudomonas, Bacillus, Alcaligenes, Aerococcus, or Rhodotorula, or with biomass using picolinic acid, which grow with picolinic acid as the sole carbon, nitrogen and energy source.

Abstract translation: 从吡啶甲酸和/或其盐开始生产6-羟基吡啶甲酸的微生物过程。 选择吡啶甲酸和/或其盐的浓度使得6-羟基吡啶甲酸不被进一步代谢。 该方法由假单胞菌属，芽孢杆菌属，产碱杆菌属，Aerococcus属或红酵母属的微生物或与使用吡啶甲酸作为唯一碳，氮和能源生长的吡啶甲酸的生物质进行。

公开(公告)号：US5173412A

公开(公告)日：1992-12-22

申请号：US788375

申请日：1991-11-06

Applicant: Andreas Kiener ,  Klaus Heinzmann ,  Michael Bokel

Inventor： Andreas Kiener ,  Klaus Heinzmann ,  Michael Bokel

IPC: C12P17/14 ,  C07D241/12 ,  C07D241/18 ,  C12N1/21 ,  C12P17/12 ,  C12R1/01

CPC classification number: C12R1/01 ,  C07D241/18 ,  C12P17/12 ,  Y10S435/822

Abstract: Microorganisms, which are capable of growing with pyrazine as the sole carbon, nitrogen and energy source. These microorganisms hydroxylate pyrazine derivatives of general formula: ##STR1## to hydroxylated pyrazine derivatives of general formula: ##STR2## and the latter are accumulated in the growth medium.

Abstract translation: 能够以吡嗪为唯一碳，氮和能源生长的微生物。 这些微生物将通式如下的羟基化吡嗪衍生物：通式Ⅰ的羟基化吡嗪衍生物与后者在生长培养基中积累。

公开(公告)号：US06214604B1

公开(公告)日：2001-04-10

申请号：US08952295

申请日：1997-11-10

Applicant: Andreas Kiener ,  Jean-Paul Roduit ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Jean-Paul Roduit ,  Klaus Heinzmann

IPC: C12N120

CPC classification number: C12R1/38 ,  C12P17/12 ,  C12P41/006

Abstract: A biologically pure culture of microorganisms capable of converting RS-&agr;-piperazinecarboxamides into the corresponding R-&agr;-piperazinecarboxylic acid. R-&agr;-piperazinecarboxamides is the only nitrogen source.

Abstract translation: 能够将RS-α-哌嗪甲酰胺转化为相应的R-α-哌嗪甲酸的生物学纯的微生物培养物。 R-α-哌嗪甲酰胺是唯一的氮源。

公开(公告)号：US20070196900A1

公开(公告)日：2007-08-23

申请号：US11674664

申请日：2007-02-13

Applicant: Hubert Muellner ,  Martin Folger ,  Andreas Werner ,  Uwe Gierlich ,  Kurt Eyer ,  Klaus Heinzmann ,  Nicholas Shaw ,  Fabian Wyer

Inventor： Hubert Muellner ,  Martin Folger ,  Andreas Werner ,  Uwe Gierlich ,  Kurt Eyer ,  Klaus Heinzmann ,  Nicholas Shaw ,  Fabian Wyer

IPC: C12P21/06 ,  C12N1/21 ,  C07K7/60

CPC classification number: C07K14/31

Abstract: The present invention relates to the manufacture of antibiotic compounds of the class known as lantibiotics. Preferably, the present invention relates to the purification of those lantibiotics.

Abstract translation: 本发明涉及抗生素类化合物的制造，称为羊毛抗生素。 优选地，本发明涉及这些羊毛硫抗生素的纯化。

公开(公告)号：US5266482A

公开(公告)日：1993-11-30

申请号：US888659

申请日：1992-05-27

Applicant: Andreas Kiener ,  Klaus Heinzmann ,  Michael Bokel

Inventor： Andreas Kiener ,  Klaus Heinzmann ,  Michael Bokel

IPC: C07D241/18 ,  C12P17/12 ,  C12R1/01

CPC classification number: C12R1/01 ,  C07D241/18 ,  C12P17/12 ,  Y10S435/822

Abstract: Microorganisms, which are capable of growing with pyrazine as the sole carbon, nitrogen and energy source. These microorganisms hydroxylate pyrazine derivatives of general formula: ##STR1## to hydroxylated pyrazine derivatives of general formula: ##STR2## and the latter are accumulated in the growth medium.

Abstract translation: 能够以吡嗪为唯一碳，氮和能源生长的微生物。 这些微生物将通式如下的羟基化吡嗪衍生物：通式Ⅰ的羟基化吡嗪衍生物与后者在生长培养基中积累。

公开(公告)号：US5364940A

公开(公告)日：1994-11-15

申请号：US90951

申请日：1993-07-13

Applicant: Andreas Kiener ,  Andreas Tschech ,  Andreas Tinschert ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Andreas Tschech ,  Andreas Tinschert ,  Klaus Heinzmann

IPC: C07D213/80 ,  C07D239/34 ,  C07D241/08 ,  C07D241/14 ,  C07D241/24 ,  C12N1/20 ,  C12P7/02 ,  C12P7/40 ,  C12P17/12 ,  C12R1/01 ,  C07D241/02 ,  C07D211/72 ,  C07D211/84

CPC classification number: C07D213/80 ,  C07D241/24 ,  C12P17/12 ,  C12R1/01 ,  Y10S435/822

Abstract: A new microbiological process for the production of hydroxy-nitrogen-heterocyclic-carboxylic acids or their soluble salts of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl group and X is a nitrogen atom or a CR.sub.3 function, wherein R.sub.3 is a hydrogen atom or a halogen atom, starting from the corresponding nitrogen-heterocyclic-carboxylic acids, as well as new microorganisms suitable for use in the process.

Abstract translation: 用于生产羟基 - 氮杂环羧酸或其可溶性盐的新的微生物方法，其通式如下：其中R 1和R 2相同或不同，并且各自为氢原子，卤素原子或 C1-C4烷基，X为氮原子或CR3官能团，其中R3为氢原子或卤素原子，起始于相应的氮杂环羧酸，以及适用于该方法的新微生物。

公开(公告)号：US5268294A

公开(公告)日：1993-12-07

申请号：US887884

申请日：1992-05-26

Applicant: Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

Inventor： Andreas Kiener ,  Rainer Glockler ,  Klaus Heinzmann

IPC: C12P17/12 ,  C12R1/05 ,  C12R1/01

CPC classification number: C12R1/05 ,  C12P17/12 ,  Y10S435/829

Abstract: A microbiological process for the production of 6-hydroxypicolinic acid starting from picolinic acid and/or its salts. The concentration of picolinic acid and/or its salts is selected so that the 6-hydroxypicolinic acid is not further metabolized. The process is performed either by microorganisms of genus Pseudomonas, Bacillus, Alcaligenes, Aerococcus, or Rhodotorula, or with biomass using picolinic acid, which grow with picolinic acid as the sole carbon, nitrogen and energy source.

Abstract translation: 从吡啶甲酸和/或其盐开始生产6-羟基吡啶甲酸的微生物过程。 选择吡啶甲酸和/或其盐的浓度使得6-羟基吡啶甲酸不被进一步代谢。 该方法由假单胞菌属，芽孢杆菌属，产碱杆菌属，Aerococcus属或红酵母属的微生物或与使用吡啶甲酸作为唯一碳，氮和能源生长的吡啶甲酸的生物质进行。