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    Selective deconvolution of an image
    2.
    发明申请
    Selective deconvolution of an image 审中-公开
    图像的选择性去卷积

    公开(公告)号：US20050276512A1

    公开(公告)日：2005-12-15

    申请号：US10858130

    申请日：2004-06-01

    Applicant: Matthew Atkinson ,  Kurt Halverson

    Inventor： Matthew Atkinson ,  Kurt Halverson

    IPC: G06K9/00 ,  G06T5/00

    CPC classification number: G06T5/003 ,  G06T7/11 ,  G06T7/136 ,  G06T2207/10064 ,  G06T2207/20012 ,  G06T2207/30072

    Abstract: A method and system are provided for the selective use of deconvolution to reduce crosstalk between features of an image. The method to select areas of an image for deconvolution comprising the steps of: a) providing an image comprising a plurality of features, wherein each feature is associated with at least one value (v); b) identifying a test feature which is a high-value feature adjacent to a known low-value zone of the image, wherein the test feature has a tail ratio (rt), which is the ratio of the value of the test feature (vt) to the value of the adjacent low-value zone of the image (vo); c) calculating a threshold value t which is a function of tail ratio (rt) of the test feature; and d) identifying selected areas of the image, the selected areas being those where the ratio of values (v) between adjacent features is greater than said threshold value (T(rt)). Typically, the method of the present invention additionally comprises the step of deconvolving the selected areas of the image.

    Abstract translation: 提供了一种用于选择性地使用去卷积以减少图像特征之间的串扰的方法和系统。 选择用于去卷积的图像的区域的方法包括以下步骤：a）提供包括多个特征的图像，其中每个特征与至少一个值（v）相关联; b）识别作为与所述图像的已知低值区相邻的高价值特征的测试特征，其中所述测试特征具有尾比（r SUB t），所述比值是 测试特征的值（v> t ）与图像的相邻低值区域的值（v> o>）; c）计算作为测试特征的尾比（r >t ）的函数的阈值t; 以及d）识别所述图像的选定区域，所选择的区域是相邻特征之间的值（v）的比值大于所述阈值（T（r））的那些区域。 通常，本发明的方法还包括对图像的选定区域进行去卷积的步骤。

    DETECTION ARTICLE HAVING FLUID CONTROL FILM
    4.
    发明申请
    DETECTION ARTICLE HAVING FLUID CONTROL FILM 有权
    具有流体控制膜的检测文章

    公开(公告)号：US20070212266A1

    公开(公告)日：2007-09-13

    申请号：US11751681

    申请日：2007-05-22

    Applicant: Raymond Johnston ,  Patrick Fleming ,  Kurt Halverson ,  James Bentsen ,  Gary Krejcarek ,  Koichi Sano

    Inventor： Raymond Johnston ,  Patrick Fleming ,  Kurt Halverson ,  James Bentsen ,  Gary Krejcarek ,  Koichi Sano

    IPC: B32B5/02

    CPC classification number: B01L3/502746 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406

    Abstract: The present invention provides a detection article including at least one fluid control film layer having at least one microstructured major surface with a plurality of microchannels therein. The microchannels are configured for uninterrupted fluid flow of a fluid sample throughout the article. The film layer includes an acquisition zone for drawing the fluid sample into the plurality of microchannels at least by spontaneous fluid transport. The film layer also includes a detection zone having at least one detection element that facilitates detection of a characteristic of the fluid sample within at least one microchannel of the detection zone. The detection article may be formed from a plurality of film layers that are stacked to form a three-dimensional article.

    Abstract translation: 本发明提供了一种检测制品，其包括至少一个具有至少一个微结构化主表面的流体控制膜层，其中具有多个微通道。 微通道配置成在整个制品中流体样品的不间断流体流动。 薄膜层包括用于至少通过自发流体输送将流体样品拉入多个微通道的采集区域。 膜层还包括具有至少一个检测元件的检测区域，其有助于检测检测区域的至少一个微通道内的流体样品的特性。 检测制品可以由层叠以形成三维制品的多个膜层形成。

    Devices, methods and systems for low volume microarray processing
    6.
    发明申请
    Devices, methods and systems for low volume microarray processing 审中-公开
    用于低体积微阵列处理的设备，方法和系统

    公开(公告)号：US20050163664A1

    公开(公告)日：2005-07-28

    申请号：US11030251

    申请日：2005-01-06

    Applicant: Kurt Halverson ,  Anila Prabhu ,  Steven Botzet

    Inventor： Kurt Halverson ,  Anila Prabhu ,  Steven Botzet

    IPC: B01L3/00

    CPC classification number: B01L3/5027 ,  B01J2219/00527 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00637 ,  B01J2219/00639 ,  B01J2219/00641 ,  B01J2219/00677 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00889 ,  B01L3/5088 ,  B01L2200/0642 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0457 ,  B82Y30/00 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499 ,  Y10T436/143333 ,  Y10T436/2575

    Abstract: Devices, methods and systems for low volume microarray processing are disclosed. The microarray devices preferably include a plurality of reactant sites on a reactant surface. The reactant sites include reactants that operate to capture one or more selected analytes that can then be detected based on an electromagnetic signal, e.g., fluorescence, that is emitted by each analyte in response to excitation energy incident on the microarray device. Mixing and/or distribution of the analyte sample over the reactant surface is accomplished by tilting the reactant surface such that the analyte sample flows over the reactant surface under the force of gravity. The tilting is performed such that a portion of the analyte sample accumulates in a bead along a first edge of the reactant surface. The reactant surface is then tilted in a different direction such that a portion of the analyte sample flows over the reactant surface and accumulates at a second edge. The reactant surface preferably generates sufficient capillary forces with the analyte sample such that the analyte sample is retained on the reactant surface. The tilting and resultant flow may be performed as many times as necessary to obtain the desired mixing and/or distribution of analyte sample over the reactant surface.

    Abstract translation: 公开了用于低体积微阵列处理的装置，方法和系统。 微阵列装置优选在反应物表面上包括多个反应物位点。 反应物位点包括反应物，其操作以捕获一种或多种选择的分析物，其然后可以基于由每个分析物响应入射在微阵列装置上的激发能量发射的电磁信号（例如荧光）而被检测。 分析物样品在反应物表面上的混合和/或分布通过倾斜反应物表面来实现，使得分析物样品在重力的作用下在反应物表面上流动。 进行倾斜使得一部分分析物样品沿着反应物表面的第一边缘积聚在珠粒中。 然后将反应物表面沿不同的方向倾斜，使得一部分分析物样品在反应物表面上流动并在第二边缘积聚。 反应物表面优选地与分析物样品产生足够的毛细管力，使得分析物样品保留在反应物表面上。 可以根据需要多次进行倾斜和产生的流动，以获得分析物样品在反应物表面上的期望的混合和/或分布。

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