公开(公告)号：US11268056B2

公开(公告)日：2022-03-08

申请号：US16067495

申请日：2016-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGICES AG

Inventor： Lars Norderhaugh ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: C12M1/26 ,  B03C1/30 ,  B03C1/01 ,  B03C1/28 ,  A61M1/36 ,  B01L3/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C07K16/28

Abstract: Methods of separating magnetic particles from a fluid include introducing a fluid mixture that includes a liquid media, a biological component, and magnetic particles into an internal compartment of a container through an inlet, allowing at least a portion of the mixture to travel around a partition formed within the internal compartment and then exit the internal compartment through an outlet on the opposite side of the partition, and applying a magnetic field to the mixture in the internal compartment so that the magnetic particles are retained within the container or internal compartment thereof by the magnetic field. The partition is formed by permanently or reversibly securing upper and lower container walls together, such as by welding or pressing, between the inlet and the outlet such that the media and biological component must flow around the partition and through the magnetic field to exit the internal compartment through the outlet.

公开(公告)号：US20190010435A1

公开(公告)日：2019-01-10

申请号：US16067495

申请日：2016-12-21

Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIFE TECHNOLOGICES AG

Inventor： Lars Norderhaugh ,  Angel Varela-Rohena ,  Nephi D. Jones

IPC: C12M1/26 ,  B03C1/30 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: Methods of separating magnetic particles from a fluid include introducing a fluid mixture that includes a liquid media, a biological component, and magnetic particles into an internal compartment of a container through an inlet, allowing at least a portion of the mixture to travel around a partition formed within the internal compartment and then exit the internal compartment through an outlet on the opposite side of the partition, and applying a magnetic field to the mixture in the internal compartment so that the magnetic particles are retained within the container or internal compartment thereof by the magnetic field. The partition is formed by permanently or reversibly securing upper and lower container walls together, such as by welding or pressing, between the inlet and the outlet such that the media and biological component must flow around the partition and through the magnetic field to exit the internal compartment through the outlet.