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    Capacitance detection in electrochemical assay
    2.
    发明授权
    Capacitance detection in electrochemical assay 有权

    公开(公告)号：US09645104B2

    公开(公告)日：2017-05-09

    申请号：US14246592

    申请日：2014-04-07

    Applicant: LifeScan Scotland Limited

    Inventor： David Elder ,  Sven Rippel

    IPC: G01R27/26 ,  G01N27/30 ,  G01N27/327 ,  G01N27/22

    CPC classification number: G01N27/307 ,  G01N27/22 ,  G01N27/3274

    Abstract: A method and system are provided to determine fill sufficiency of a biosensor test chamber by determining capacitance of the test chamber in which an electrochemical reaction is initiated in the test chamber and an oscillating voltage of a predetermined frequency is applied to the chamber. A phase angle between a current output and the oscillating voltage from the chamber is determined and the capacitance is calculated based on a product of the current output and a sine of the phase angle divided by a product of two times pi times the frequency and the voltage.

    Analyte measurement method and system
    3.
    发明授权
    Analyte measurement method and system 有权
    分析物测量方法和系统

    公开(公告)号：US09500618B2

    公开(公告)日：2016-11-22

    申请号：US14606317

    申请日：2015-01-27

    Applicant: LifeScan Scotland Limited

    Inventor： Michael Malecha ,  Adam Craggs

    IPC: G01N27/327 ,  G06F19/10

    CPC classification number: G01N27/3274 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/49 ,  G06F19/10

    Abstract: Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.

    Abstract translation: 本文描述和示出了操作具有仪表和测试条的分析物测量系统的系统和示例性方法。 在一个实施例中，可以通过在参考电极和第二工作电极之间施加第一测试电压并且在参考电极和第一工作电极之间施加第二测试电压来实现该方法; 将含有分析物的血液样本施加到测试条上之后，测量第二工作电极处的第一测试电流，第二测试电流，第三测试电流和第四测试电流; 在第一工作电极处测量第五测试电流; 从第一，第二，第三，第四和第五测试电流估计血细胞比容校正的分析物浓度; 并说明血细胞比容校正的分析物浓度。

    ANALYTE METER AND METHOD OF OPERATION
    4.
    发明申请
    ANALYTE METER AND METHOD OF OPERATION 审中-公开
    分析仪和操作方法

    公开(公告)号：US20160299097A1

    公开(公告)日：2016-10-13

    申请号：US15184133

    申请日：2016-06-16

    Applicant: LifeScan Scotland Limited

    Inventor： Timothy LLOYD ,  David MCCOLL ,  Antony SMITH ,  Brian GUTHRIE ,  David ELDER ,  Rossano MASSARI ,  Christian FORLANI

    IPC: G01N27/327

    CPC classification number: G01N27/3273 ,  G01N27/3274 ,  G01N27/3275

    Abstract: An analyte meter having a test strip port is configured to transmit an electric signal through a received test strip with a sample. A pair of electrodes apply the electric signal and receive an electrical response from the test strip. A processing unit analyzes the electrical response and uses the response to determine an analyte level of the sample.

    Abstract translation: 具有测试条端口的分析物计量器被配置为通过带有样品的接收的测试条来传输电信号。 一对电极施加电信号并从测试条接收电响应。 处理单元分析电响应并使用响应来确定样品的分析物水平。

    End-fill electrochemical-based analytical test strip with perpendicular intersecting sample-receiving chambers
    6.
    发明授权
    End-fill electrochemical-based analytical test strip with perpendicular intersecting sample-receiving chambers 有权
    具有垂直相交的样品接收室的基于末端填充的基于电化学的分析测试条

    公开(公告)号：US09453812B2

    公开(公告)日：2016-09-27

    申请号：US14313377

    申请日：2014-06-24

    Applicant: LifeScan Scotland Limited

    Inventor： Alexander Cooper ,  Antony Smith ,  Lynsey Whyte ,  Neil Whitehead ,  David McColl ,  Brian Guthrie ,  Timothy Lloyd ,  Rossano Massari ,  Christian Forlani

    IPC: G01N17/00 ,  G01N27/327 ,  G01N33/00 ,  G01N30/64 ,  G01N31/16

    CPC classification number: G01N27/327 ,  B01L2300/0645 ,  G01N27/3272 ,  G01N31/164 ,  G01N33/0031 ,  G01N2030/645

    Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner.

    Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特征（例如，血细胞比容）的基于电化学的分析测试条包括样品 具有设置在基于电化学的分析测试条的端部边缘上的样品施加开口的第一和第二样品室，以及与样品入口室直接流体连通的第一和第二样品测定室。 基于电化学的分析测试条还包括设置在第一样品测定室中的第一和第二电极（例如第一和第二血细胞比容电极）和设置在第二样品中的第三和第四电极（例如工作和参考电极） 测定室。 此外，第一和第二样品确定室将样品入口室彼此垂直（或几乎垂直）相交，并且第一样品测定室也以对准的方式与样品入口室相交。

    HAND-HELD TEST METER WITH TEST STRIP ELECTRODE TO GROUND-REFERENCE SWITCH CIRCUIT BLOCK
    8.
    发明申请
    HAND-HELD TEST METER WITH TEST STRIP ELECTRODE TO GROUND-REFERENCE SWITCH CIRCUIT BLOCK 审中-公开
    带测试条电极的手持式测试仪接地参考开关电路块

    公开(公告)号：US20160178561A1

    公开(公告)日：2016-06-23

    申请号：US14615745

    申请日：2015-02-06

    Applicant: LifeScan Scotland Limited

    Inventor： Malcolm HAMER ,  Jonathan NELSON

    IPC: G01N27/327

    CPC classification number: G01N27/3273 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3274

    Abstract: A hand-held test meter for use with an electrochemical-based analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a micro-controller disposed in the housing, a test strip electrode to ground-reference switch circuit block disposed in the housing, a strip port connector configured for operational insertion of an electrochemical-based analytical test strip with an electrode (e.g., a reference electrode), and a ground-reference. In addition, the test strip electrode to ground-reference switch circuit block is configured to be in electrical communication with an electrode of an electrochemical-based analytical test strip inserted in the strip port connector. Moreover, the test strip electrode to ground-reference switch circuit block is configured to connect and disconnect the electrode of the inserted electrochemical-based analytical test strip to the ground-reference under operational control of the micro-controller.

    Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的电化学分析测试条中使用的手持式测试仪包括壳体，设置的微控制器 在壳体中，设置在壳体中的测试条电极到接地参考开关电路块，配置成用于将电化学基分析测试条与电极（例如，参考电极）和地面操作插入的带状端口连接器 -参考。 此外，测试条电极至接地参考开关电路块被配置为与插入带状端口连接器中的基于电化学的分析测试条的电极电连通。 此外，测试条电极到接地参考开关电路块被配置为在微控制器的操作控制下将插入的基于电化学的分析测试条的电极连接和断开到接地参考。

    HAND-HELD TEST MESTER WITH LOW-DISTORTION SIGNAL GENERATION CIRCUIT BLOCK
    9.
    发明申请
    HAND-HELD TEST MESTER WITH LOW-DISTORTION SIGNAL GENERATION CIRCUIT BLOCK 有权
    具有低失真信号发生电路块的手持测试仪

    公开(公告)号：US20150355131A1

    公开(公告)日：2015-12-10

    申请号：US14300454

    申请日：2014-06-10

    Applicant: LifeScan Scotland Limited

    Inventor： David ELDER ,  Rossano MASSARI

    IPC: G01N27/327

    CPC classification number: G01N27/3273 ,  G01N27/3271 ,  G01N27/3274 ,  G01R23/20 ,  G01R29/26

    Abstract: A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a clock module disposed in the housing, a micro-controller disposed in the housing, a low-distortion signal generation circuit block (“LDSGCB”) disposed in the housing, and a strip port connector configured to operationally receive the analytical test strip. The LDSGCB includes a signal summation circuit (“SSC”) sub-block, a resistance-capacitance (RC) filter, and a single operational amplifier. The clock module and micro-controller are configured to generate phase-shifted square wave signals and output the phase-shifted square wave signals to the SSC. The SSC is configured to sum the phase-shifted square wave signals to generate a resultant summed-wave signal and output the resultant summed-wave signal to the RC filter. The RC filter is configured to filter harmonics from the resultant summed-wave signal thereby creating a reduced harmonic distortion signal.

    Abstract translation: 用于测定体液样品中的分析物的分析测试条的手持式测试仪包括壳体，设置在壳体中的时钟模块，设置在壳体中的微控制器，低失真信号 设置在壳体中的发生电路块（“LDSGCB”）以及被配置为可操作地接收分析测试条的条形端口连接器。 LDSGCB包括信号求和电路（“SSC”）子块，电阻电容（RC）滤波器和单个运算放大器。 时钟模块和微控制器被配置为产生相移方波信号并将相移的方波信号输出到SSC。 SSC被配置为对相移的方波信号求和以产生合成的和波信号，并将所得的和波信号输出到RC滤波器。 RC滤波器被配置为从所得到的和波信号中滤除谐波，从而产生减小的谐波失真信号。

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