公开(公告)号：US20250100024A1

公开(公告)日：2025-03-27

申请号：US18796919

申请日：2024-08-07

Applicant: MILESTONE S.r.l.

Inventor： Francesco Visinoni ,  Matteo Minuti ,  Omar Roncalli

IPC: B08B3/14

Abstract: A basin (1) for cleaning a tool used during a histology procedure such as a grossing procedure. The basin (1) comprises: a cleaning chamber (10) delimited by a side wall (11) extending from a bottom (12); an inlet conduit (30) arranged to deliver a cleaning liquid via an outlet opening (31) into the cleaning chamber (10), wherein the inlet conduit (30) extends through the side wall (11) and/or the bottom (12); and a liquid conditioning conduit (50) arranged to subject the cleaning liquid to a venturi effect and/or to cavitation upstream of the outlet opening (31).

公开(公告)号：US11577208B2

公开(公告)日：2023-02-14

申请号：US16529074

申请日：2019-08-01

Applicant: MWT AG ,  Milestone S.r.l.

Inventor： Werner Lautenschläger ,  Jens Lautenschläger ,  Werner Scholze

IPC: B01J3/00 ,  G01N21/03 ,  G01J5/061 ,  G01J5/02 ,  B01J3/04 ,  B01F33/45

Abstract: The present invention relates to a pressure vessel (1) having a pressure vessel wall (1a) which completely surrounds a reaction chamber (2) as a pressure space for the initiation and/or promotion of chemical and/or physical pressure reactions of a sample (P) to be heated which is accommodated in the reaction chamber (2), wherein the pressure vessel wall (1a) has an infrared-permeable high-pressure window (30) which extends away outward in a direction from the reaction chamber (2) and which is supported in the pressure vessel wall (1a) with respect to a pressure in the reaction chamber (2), wherein the pressure vessel (1) furthermore has an infrared to temperature sensor (40) which is situated directly opposite the high-pressure window (30), in order to measure the temperature of a sample (P), accommodated in the reaction chamber (2), during a pressure reaction through the high-pressure window (30).

公开(公告)号：US11085873B2

公开(公告)日：2021-08-10

申请号：US16348684

申请日：2017-11-10

Applicant: Mikrowellen Labor Technik AG ,  Milestone S.r.l.

Inventor： Werner Lautenschläger ,  Jens Lautenschläger

IPC: G01N21/31 ,  G01J3/42 ,  G01J3/18 ,  H01J61/06

Abstract: The present invention relates a spectrometer (1) having a lamp (2) that extends in substantially tubular fashion for the purposes of forming a light emission zone (3) that extends in the direction of the tubular extent and between two points to the end of emitting a first light beam (L1) and a second light beam (L2) that have the same origin on the light emission zone (3), a sample container (6) that is arranged in the beam path of the first light beam (L1) for receiving a sample to be measured, a first detection apparatus (D1) that is arranged in the direction of the first light beam (L1) for quantitative and/or qualitative determination of the sample to be measured in the sample container (6) on the basis of an interaction between the sample to be measured and the first light beam (L1), and a second detection apparatus (D2) that is arranged in the direction of the second light beam (L2) for the purposes of referencing the quantitative and/are qualitative determination, on the basis of the second light beam (L2), of the sample to be measured. The invention further relates to a spectrometer (1′) having a lamp (2) that extends in substantially tubular fashion for the purposes of emitting at least two light beams (L1, L3), respectively one sample container (6, 16) arranged in the beam path of each light beam (L1, L3) for the purposes of receiving a sample to be measured, and a detection apparatus (D1, D3) that is arranged in the direction of each light beam (L1, L3) for the purposes of quantitative and/or qualitative determination of the sample to be measured in the respective sample container (6, 16) on the basis of an interaction between the sample to be measured and the respective light beam (L1, L3).

公开(公告)号：US20190316994A1

公开(公告)日：2019-10-17

申请号：US16260639

申请日：2019-01-29

Applicant: Milestone S.r.l.

Inventor： Francesco Visinoni ,  Matteo Minuti

IPC: G01N1/31 ,  G01N1/36 ,  A61B10/00

Abstract: The present invention refers to an apparatus (100) for identification of tissue carriers (210) of human or animal tissue that are grouped in a batch (200), wherein the apparatus (100) comprises a working area (110) for receiving the batch (200) of at least two tissue carriers (210); a presence sensor (120) for detecting the presence of each of the tissue carriers (210) of the batch (200) received at the working area (110); an identification device (130) for detecting a unique identifier (220) of each of the tissue carriers (210) of the batch (200) received at the working area (110); and a control unit (140, 141, 142) being configured to identify positions of the working area (110), at which a tissue carrier (210) is detected to be present but no unique identifier (220) is detected and/or at which a unique identifier (220) is detected but no tissue carrier (210) is detected to be present, as identified positions. The present invention further refers to a system (300) as well as a method for tracking and identification of tissue carriers (210) of human or animal tissue.

公开(公告)号：US20240019345A1

公开(公告)日：2024-01-18

申请号：US18200287

申请日：2023-05-22

Applicant: MILESTONE s.r.l.

Inventor： Francesco Visinoni ,  Matteo Minuti ,  Michele Martinelli ,  Roberto Lorenzi

IPC: G01N1/30 ,  G01N1/31 ,  B01L3/00

CPC classification number: G01N1/30 ,  G01N1/31 ,  B01L3/50 ,  B01L2300/022 ,  G01N2001/305 ,  B01L2300/04

Abstract: The invention refers to a container (100, 300, 400) for collecting, transporting and storing a biological tissue sample of a human or animal, wherein the container (100, 300, 400) comprises a tag (10) with a receiver (12.1) for receiving data relating to the biological tissue sample, a non-volatile memory (11) for storing the data received by the receiver (12.1), and a transmitter (12.2) for transmitting the data stored by the memory (11).

公开(公告)号：US11117695B2

公开(公告)日：2021-09-14

申请号：US16414032

申请日：2019-05-16

Applicant: Milestone S.r.l.

Inventor： Francesco Visinoni ,  Matteo Minuti ,  Marco Bellini ,  Michele Bellini ,  Michele Martinelli

IPC: B65B31/02 ,  A61J1/14 ,  B65B3/00 ,  B65B3/26 ,  A01N1/02

Abstract: The present invention relates to a method and a system (400) for filling a closed container (200) with a fixative solution. The system comprises a container (200) comprising a container body (230) for receiving a biological specimen, a lid (220) for selectively closing the container body (230) and a port (100) forming a unidirectional barrier in a direction from the inside (IC) to the outside (OC) of the closed container (200). The system further comprises a dispensing apparatus (500) having a filling nozzle (300) for dispensing the fixative solution. The filling nozzle (300) is relatively moveable with respect to the container (200) between a retracted position and a filling position to fill the container (200) with the fixative solution.

公开(公告)号：US20190391072A1

公开(公告)日：2019-12-26

申请号：US16348684

申请日：2017-11-10

Applicant: Mikrowellen Labor Technik AG ,  Milestone S.r.l.

Inventor： Werner Lautenschläger ,  Jens Lautenschläger

IPC: G01N21/31 ,  G01J3/42 ,  G01J3/18 ,  H01J61/06

Abstract: The present invention relates a spectrometer (1) having a lamp (2) that extends in substantially tubular fashion for the purposes of forming a light emission zone (3) that extends in the direction of the tubular extent and between two points to the end of emitting a first light beam (L1) and a second light beam (L2) that have the same origin on the light emission zone (3), a sample container (6) that is arranged in the beam path of the first light beam (L1) for receiving a sample to be measured, a first detection apparatus (D1) that is arranged in the direction of the first light beam (L1) for quantitative and/or qualitative determination of the sample to be measured in the sample container (6) on the basis of an interaction between the sample to be measured and the first light beam (L1), and a second detection apparatus (D2) that is arranged in the direction of the second light beam (L2) for the purposes of referencing the quantitative and/are qualitative determination, on the basis of the second light beam (L2), of the sample to be measured. The invention further relates to a spectrometer (1′) having a lamp (2) that extends in substantially tubular fashion for the purposes of emitting at least two light beams (L1, L3), respectively one sample container (6, 16) arranged in the beam path of each light beam (L1, L3) for the purposes of receiving a sample to be measured, and a detection apparatus (D1, D3) that is arranged in the direction of each light beam (L1, L3) for the purposes of quantitative and/or qualitative determination of the sample to be measured in the respective sample container (6, 16) on the basis of an interaction between the sample to be measured and the respective light beam (L1, L3).

公开(公告)号：US20190033179A1

公开(公告)日：2019-01-31

申请号：US16002409

申请日：2018-06-07

Applicant: MILESTONE S.r.l.

Inventor： Matteo Minuti ,  Francesco Visinoni

IPC: G01N1/30 ,  G01N35/00 ,  B01L3/00 ,  G01N1/36

Abstract: The invention relates to a tissue processor (100) for automatically processing histological tissue specimens, the tissue processor (100) comprising a plurality of containers (1, 2, 3, 4, 5, 6, 7) each being provided for a respective histological process for processing at least one tissue carrier, a robotic arm (9) for handling a tissue carrier between the containers (1, 2, 3, 4, 5, 6, 7) for being processed in each of the containers (1, 2, 3, 4, 5, 6, 7), and a control unit for controlling the histological process in each of the containers (1, 2, 3, 4, 5, 6, 7) and for controlling the robotic arm (9), wherein the control unit is configured such that the robotic arm (9) handles a tissue carrier between the containers (1, 2, 3, 4, 5, 6, 7) while the histological process in each of the containers (1, 2, 3, 4, 5, 6, 7) continues in an uninterrupted fashion, so that the execution of the process for each tissue carrier is independent from the loading order and/or process duration of other tissue carriers being processed in the containers (1, 2, 3, 4, 5, 6, 7).

公开(公告)号：US20030194352A1

公开(公告)日：2003-10-16

申请号：US10368582

申请日：2003-02-20

Applicant: MILESTONE S.R.L.

Inventor： Werner Lautenschlager

IPC: B01L003/00

CPC classification number: B01J3/03 ,  B01J19/126 ,  B01J2219/1209 ,  B01J2219/1218 ,  B01J2219/1233 ,  B01J2219/1257 ,  B01J2219/126 ,  G01N1/44

Abstract: The invention relates to a device 51 for closing a plurality of digestion vessels 1 the openings of which are in each case covered by a cover 3, comprising a plurality of positioning spaces 53 for the digestion vessels, the positioning spaces 53 being able to be distributed in a circumferential row R1 and being accessible from outside, and a plurality of closing devices 73 for pressing the covers 3 against the vessels. In order to improve the capacity of the device 51 with regard to the number of digestion vessels 1 further inner positioning spaces 53 are arranged to be offset inwardly with respect to said positioning spaces 53.

Abstract translation: 本发明涉及一种用于关闭多个消化容器的装置。粗体1 其开口在每种情况下被盖子 3覆盖， 包括用于消化容器的多个定位空间 53 ，定位空间 53 能够分布在圆周行R 1 中，并且 以及多个关闭装置 73 ，用于将盖子 3 按压在船上。 为了提高设备的容量 51 关于消化容器的数量 1 进一步将内部定位空间 53 排列为偏移量 相对于所述定位空间（粗体）53。

公开(公告)号：US11629793B2

公开(公告)日：2023-04-18

申请号：US17090175

申请日：2020-11-05

Applicant: MILESTONE S.r.l.

Inventor： Francesco Visinoni ,  Matteo Minuti ,  Michele Bellini

IPC: F16K15/14

Abstract: The invention relates to a valve (1) for mounting to a surface (2) and for use in a flow path, which flows through said surface (2), for permitting flow in said flow path in a first direction and for preventing flow in said flow path in a second direction being opposite to the first direction. The valve (1) comprises: one or more ports (21) defined by a plurality of lips (22), wherein each lip (22) is resiliently deformable from a first position, in which the lips (22) are in contact with one another in order to close the respective port (21), to a second position, in which the respective port (21) is opened in order to permit flow in the first direction, and one or more contacting structures (30) arranged to mechanically contact the surface (2), when the valve is mounted to the surface (2), such that the one or more contacting structures (30) bias the lips (22) into the first position.