公开(公告)号：US20110119034A1

公开(公告)日：2011-05-19

申请号：US12970019

申请日：2010-12-16

Applicant: Mirko LIEDTKE ,  Frank KLEMM ,  Manfred LOTH

Inventor： Mirko LIEDTKE ,  Frank KLEMM ,  Manfred LOTH

IPC: G06F15/00

CPC classification number: G02B21/0076 ,  G01J3/2889 ,  G01J3/4406

Abstract: A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.

Abstract translation: 一种用于记录允许重建时间基准的脉冲信号的方法。 可以通过使用已知的采样频率对相应采样结果位之前的采样结果位进行计数来确定每个脉冲信号事件的时间。 为此，采样频率的每个周期都与表示相应采样结果的位相关联，采样结果位逐个存储，每个通道存储在数据块中。 采样频率优选地高于像素时钟，与被标记的像素时钟的侧面相关联的采样结果位。 因此，像素时钟可以在每个采样周期精确地与各个事件同步。 本发明还涉及使用共焦显微镜或激光扫描显微镜的荧光相关光谱领域。

公开(公告)号：US06591223B1

公开(公告)日：2003-07-08

申请号：US09694874

申请日：2000-10-23

Applicant: Albrecht Geist ,  Frank Klemm ,  Manfred Loth

Inventor： Albrecht Geist ,  Frank Klemm ,  Manfred Loth

IPC: G06F1500

CPC classification number: G01J3/457 ,  G01D9/005 ,  G01J3/4406 ,  G01J2003/2866

Abstract: A process for recording pulse signals of at least two input channels includes sampling the input channels with a predetermined sampling frequency for events which have occurred, and after detection of an event in at least one of the input channels, or after overflow of a counter, storing the present state of all the input channels in a memory register together with a magnitude characterizing a time interval to the last storage operation. The device for recording pulse signals of at least two input channels according to the process includes a clock oscillator, a sampler that samples the input channels, a counter, and a memory. The detection of a first event in one of the input channels or the overflow of the counter, according to which event occurs first, triggers and operation of storage of the states of all the input channels and of the last counter state at the occurrence of the event.

Abstract translation: 用于记录至少两个输入通道的脉冲信号的过程包括以预定的采样频率针对已发生的事件对输入通道进行采样，并且在检测至少一个输入通道中的事件之后或在计数器溢出之后， 将所有输入通道的当前状态与表征最后存储操作的时间间隔的大小一起存储在存储器寄存器中。 用于根据该过程记录至少两个输入通道的脉冲信号的装置包括时钟振荡器，对输入通道进行采样的采样器，计数器和存储器。 在一个输入通道中的第一事件的检测或计数器的溢出，根据哪个事件首先发生，触发和操作所有输入通道的状态和最后一个计数器状态的存储 事件。

公开(公告)号：US08935127B2

公开(公告)日：2015-01-13

申请号：US12970019

申请日：2010-12-16

Applicant: Mirko Liedtke ,  Frank Klemm ,  Manfred Loth

Inventor： Mirko Liedtke ,  Frank Klemm ,  Manfred Loth

IPC: G06F15/00 ,  G02B21/00 ,  G01J3/28 ,  G01J3/44

CPC classification number: G02B21/0076 ,  G01J3/2889 ,  G01J3/4406

Abstract: A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.

Abstract translation: 一种用于记录允许重建时间基准的脉冲信号的方法。 可以通过使用已知的采样频率对相应采样结果位之前的采样结果位进行计数来确定每个脉冲信号事件的时间。 为此，采样频率的每个周期都与表示相应采样结果的位相关联，采样结果位逐个存储，每个通道存储在数据块中。 采样频率优选地高于像素时钟，与被标记的像素时钟的侧面相关联的采样结果位。 因此，像素时钟可以在每个采样周期精确地与各个事件同步。 本发明还涉及使用共焦显微镜或激光扫描显微镜的荧光相关光谱领域。