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公开(公告)号：US08507670B2
公开(公告)日：2013-08-13
申请号：US12438182
申请日：2007-08-21
Applicant: Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranadheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
Inventor： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranadheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
IPC: C07D253/08 , A61K31/53 , A61P19/02
CPC classification number: A61K31/4155 , A61K31/4035 , A61K31/41 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/536 , A61K45/06 , C07D209/44 , C07D209/48 , C07D253/08 , C07D265/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10
Abstract: The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.
Abstract translation: 本发明涉及β-羟基和氨基取代的羧酸，其作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸，用于合成的相应方法和含有本发明化合物的药物组合物。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。
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公开(公告)号：US20100081610A1
公开(公告)日：2010-04-01
申请号：US12438182
申请日：2007-08-21
Applicant: Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranaheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
Inventor： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranaheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
IPC: A61K38/13 , C07D253/08 , A61K31/53 , C07D401/02 , A61K31/4439 , C07D209/44 , A61K31/404 , A61K31/5415 , A61K31/56 , C07D277/00 , A61P29/00 , A61P37/06
CPC classification number: A61K31/4155 , A61K31/4035 , A61K31/41 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/536 , A61K45/06 , C07D209/44 , C07D209/48 , C07D253/08 , C07D265/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10
Abstract: The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.
Abstract translation: 本发明涉及作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸的羟基和氨基取代的羧酸，用于合成含有本发明化合物的药物组合物的相应方法。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。
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公开(公告)号：US20230044077A1
公开(公告)日：2023-02-09
申请号：US17758668
申请日：2021-01-29
Applicant: Manoj Kumar R
Inventor： Manoj Kumar R , Vivek KEMPRAJ , Vijeth V ARYA
Abstract: The present invention discloses a formulation comprising phagostimulants or kairomones, stabilizer, emulsifying, thickening and temperature stabilizing agents to control Tephritid fruit fly (Bactrocera cucurbitae) by attracting both male and female of all stages thereby said formulation finds a prominent place in integrated pest management, control and eradication programs of tephritid fruit flies. The process of preparation of the formulation is also disclosed in the present invention.
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公开(公告)号：US20210315205A1
公开(公告)日：2021-10-14
申请号：US17272086
申请日：2019-08-27
Applicant: Timothy Spence MCCOLGAN , Madhu PANDEY , Henry Adalberto ALEGRIA , Manoj Kumar RAM
Inventor： Timothy Spence MCCOLGAN , Madhu PANDEY , Henry Adalberto ALEGRIA , Manoj Kumar RAM
Abstract: Particles comprising a core and a shell at least partially surrounding the core, wherein the core comprises a transition metal dichalcogenide and the shell comprises a transition metal oxide are disclosed. The particles can possess enhanced absorption of light in the visible and UVB/UVA spectrum, without inhibiting their inherent oxidative properties significantly. The particles inserted into a SODIS platform can possess equal or greater photocatalytic properties compared to the current TiO2 SODIS method.
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公开(公告)号：US10242406B2
公开(公告)日：2019-03-26
申请号：US12559407
申请日：2009-09-14
Applicant: Manoj Kumar , Yuan-Chi Chang , Chung-Sheng Li
Inventor： Manoj Kumar , Yuan-Chi Chang , Chung-Sheng Li
Abstract: Systems, methods and articles of manufacture are disclosed for building and executing analytics solutions. Such a solution may provide a comprehensive analytics solution (e.g., a risk assessment, fraud detection solution, dynamic operational risk evaluations, regulatory compliance assessments, etc.). The analytics solution may perform an analytics task using operational data distributed across a variety of independently created and governed data repositories in different departments of an organization. A framework is disclosed which allows a user (e.g., a risk analyst) to compose analytical tools that can access data from a variety of sources (both internal and external to an enterprise) and perform a variety of analytic functions.
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Patent Agency Ranking
公开(公告)号：US09823188B1
公开(公告)日：2017-11-21
申请号：US14834508
申请日：2015-08-25
Applicant: Manoj Kumar Ram , Muhammad Rahman
Inventor： Manoj Kumar Ram , Muhammad Rahman
IPC: G01N21/3577 , G01N21/94 , G01N21/31
CPC classification number: G01N21/3577 , G01N21/3103 , G01N21/94 , G01N2021/3595 , G01N2201/061 , G01N2201/12
Abstract: In some embodiments, a system for detecting the presence of a contaminant on a surface includes an infrared light source configured to shine infrared light on the surface, an infrared light detector configured to detect infrared light reflected from the surface, and a computing device configured to receive an infrared reflectance signal from the infrared light detector and detect the presence of the contaminant from a feature in the reflectance signal.
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公开(公告)号：US20160109776A1
公开(公告)日：2016-04-21
申请号：US14884201
申请日：2015-10-15
Applicant: Manoj Kumar Ram , D. Yogi Goswani , Elias K. Stefanakos
Inventor： Manoj Kumar Ram , D. Yogi Goswani , Elias K. Stefanakos
CPC classification number: G02F1/153 , C09K9/02 , G02B26/005 , G02F1/0018 , G02F1/15165
Abstract: The subject invention pertains to color changeable, film materials comprising a metal substrate layer; a conducting polymer or conducting polymer composite layer; and an electrolyte layer. The conducting polymer or conducting polymer composite layer of the film material is capable of exhibiting changes in one or more optical properties when the film material is in contact with a metal. The subject invention also pertains to methods of preparing conducting polymer films capable of exhibiting changes in optical properties.
Abstract translation: 本发明涉及包含金属基底层的可变色膜材料; 导电聚合物或导电聚合物复合层; 和电解质层。 当薄膜材料与金属接触时，薄膜材料的导电聚合物或导电聚合物复合层能够表现出一种或多种光学性能的变化。 本发明还涉及制备能够表现出光学性质变化的导电聚合物膜的方法。
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8.发明授权公开(公告)号：US09278296B2
公开(公告)日：2016-03-08
申请号：US13990160
申请日：2011-11-28
Applicant: Manoj Kumar Ramakrishna , Shashikanth Agnihotry
Inventor： Manoj Kumar Ramakrishna , Shashikanth Agnihotry
CPC classification number: B01D15/22 , G01N30/6004 , G01N30/6017 , G01N30/6021 , G01N30/6026 , G01N30/6047 , G01N30/6052 , Y10T29/49826 , Y10T29/49883
Abstract: The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate.
Abstract translation: 本发明涉及将分配器板固定到色谱柱的背板的方法，而不需要可释放的固定装置作为螺钉或螺栓。 本发明还涉及利用这种方法的色谱柱。 该方法采用在柱内部产生的负压或真空，以将分配器固定到背板。
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公开(公告)号：US09271728B2
公开(公告)日：2016-03-01
申请号：US13472552
申请日：2012-05-16
Applicant: Arvind Kumar Gupta , Harshottam Singh Dhakad , Manoj Kumar Agarwal , Nikhil R. Katre , Vinayan Vivekanandan
Inventor： Arvind Kumar Gupta , Harshottam Singh Dhakad , Manoj Kumar Agarwal , Nikhil R. Katre , Vinayan Vivekanandan
IPC: A61B17/068 , A61B17/072 , A61B17/00 , A61B17/32 , A61B19/00
CPC classification number: A61B17/105 , A61B17/068 , A61B17/07207 , A61B2017/0023 , A61B2017/00407 , A61B2017/07271 , A61B2017/320052 , A61B2090/0813
Abstract: A surgical fastener applying apparatus for applying fasteners to body tissue. The apparatus includes a cartridge receiving half-section defining an elongated channel member, an anvil half-section, and a clamping lever. The cartridge receiving half-section releasably receives a cartridge and a firing assembly. The clamping lever includes a protrusion in a sidewall which is receivable in a bifurcated depression formed in a sidewall of the cartridge receiving half-section to releasably retain the clamping lever in a non-clamped position and in a clamped position. The apparatus includes a disposable firing assembly and SULU.
Abstract translation: 一种用于将紧固件施加到身体组织的手术紧固件施加装置。 该装置包括限定细长通道构件，砧座半部和夹紧杆的盒接收半部。 盒接收半部分可释放地接收盒和点火组件。 夹紧杆包括在侧壁中的突起，其可接收在形成在盒接收半部的侧壁中的分叉凹部中，以可释放地将夹紧杆保持在非夹紧位置并处于夹紧位置。 该装置包括一次性点火组件和SULU。
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公开(公告)号：US09034633B2
公开(公告)日：2015-05-19
申请号：US12711533
申请日：2010-02-24
Applicant: Manoj Kumar , Mahendra Pratap Singh , Harinder Kaur Dua , Vivekanand Kagdiyal , Amarjeet Singh Sarpal , Vijay Kumar Chhatwal , Ravinder Kumar Malhotra , Anand Kumar
Inventor： Manoj Kumar , Mahendra Pratap Singh , Harinder Kaur Dua , Vivekanand Kagdiyal , Amarjeet Singh Sarpal , Vijay Kumar Chhatwal , Ravinder Kumar Malhotra , Anand Kumar
Abstract: Disclosed herein is a method for biopile-based bioremediation of hydrocarbon waste with high aromatic content. The method comprises of isolating specific microorganisms and preparing microbial blend, preparing biopile, adding the microbial blend into the biopile, providing nutrient, aeration and watering of biopile.
Abstract translation: 本文公开了一种用于具有高芳族含量的烃废物的基于生物堆的生物修复方法。 该方法包括分离特异性微生物并制备微生物混合物，制备生物堆积物，将微生物混合物加入到生物堆中，提供生物的营养，通气和浇水。
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