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    CONSTANT-FORCE SPRING SYSTEMS
    2.
    发明申请
    CONSTANT-FORCE SPRING SYSTEMS 审中-公开
    恒星弹簧系统

    公开(公告)号：US20140027965A1

    公开(公告)日：2014-01-30

    申请号：US13560231

    申请日：2012-07-27

    Applicant: Michael Holloway ,  Michael Colvin Andrews ,  Jonathan Michael Royer

    Inventor： Michael Holloway ,  Michael Colvin Andrews ,  Jonathan Michael Royer

    IPC: F16F3/04

    CPC classification number: F16F3/04

    Abstract: Adjustable constant force spring systems are disclosed. An adjustable constant-force spring system includes first and second rolled metal strips and a spool. The first strip is rolled around a first axis. The first strip has an inner end adjacent the first axis and an outer end configured for selective attachment to a load. The second strip is rolled around the first axis such that the second strip overlaps the first strip. The second strip has an inner end adjacent the first axis and an outer end configured for selective attachment to the load. The spool is located on a second axis parallel to and spaced from the first axis. The spool is sized to enable the first strip to reroll around the spool.

    Abstract translation: 公开了可调恒力弹簧系统。 可调恒力弹簧系统包括第一和第二轧制金属条和卷轴。 第一条带绕第一轴线旋转。 第一条带具有邻近第一轴线的内端和被配置用于选择性地连接到负载的外端。 第二条带围绕第一轴线滚动，使得第二条带与第一条带重叠。 第二条带具有邻近第一轴线的内端和被配置用于选择性地附接到负载的外端。 阀芯位于平行于第一轴线并与第一轴线间隔开的第二轴线上。 卷轴的尺寸设置为使第一条带能够围绕卷轴重绕。

    Systems and methods for making and using enhanced electrodes for electrical stimulation systems
    3.
    发明授权
    Systems and methods for making and using enhanced electrodes for electrical stimulation systems 有权
    制造和使用电刺激系统的增强电极的系统和方法

    公开(公告)号：US08504171B2

    公开(公告)日：2013-08-06

    申请号：US13220037

    申请日：2011-08-29

    Applicant: Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Barker

    Inventor： Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Barker

    IPC: A61N1/05

    CPC classification number: A61N1/05 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36096

    Abstract: A lead assembly for providing electrical stimulation of patient tissue includes at least one elongated lead body, each of the at least one lead bodies having a distal end and a proximal end. A plurality of electrodes are disposed at the distal end of the at least one lead body, each of the electrodes having an outer surface. A plurality of dimples are defined along the outer surface of at least one of the plurality of electrodes, the plurality of dimples configured and arranged to provide a larger surface area for the at least one dimpled electrode than that of a similarly-sized electrode with a flat outer surface. A plurality of terminal are disposed at the proximal end of the at least one lead body. A plurality of conductive wires couple each of the plurality of electrodes to at least one of the plurality of terminals.

    Abstract translation: 用于提供对患者组织的电刺激的引线组件包括至少一个细长引线体，所述至少一个引线体中的每一个具有远端和近端。 多个电极设置在至少一个引线体的远端，每个电极具有外表面。 沿着多个电极中的至少一个电极的外表面限定多个凹坑，所述多个凹坑被配置和布置成为至少一个凹凸电极提供比具有相同尺寸的电极的更大的表面积 平坦的外表面。 多个端子设置在至少一个引线体的近端处。 多个导线将多个电极中的每一个耦合到多个端子中的至少一个。

    Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces
    6.
    发明申请
    Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权

    公开(公告)号：US20050193860A1

    公开(公告)日：2005-09-08

    申请号：US11096818

    申请日：2005-03-31

    Applicant: Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

    Inventor： Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

    IPC: A61B5/00 ,  C22B4/00 ,  C21C5/52

    CPC classification number: A61B5/14865 ,  A61B5/14532

    Abstract: An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

    Multipart drug delivery system
    7.
    发明授权
    Multipart drug delivery system 失效
    多药物输送系统

    公开(公告)号：US06322815B1

    公开(公告)日：2001-11-27

    申请号：US08279302

    申请日：1994-07-22

    Applicant: W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

    Inventor： W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

    IPC: A61K914

    CPC classification number: A61K47/34 ,  A61K47/61

    Abstract: Polymeric drug conjugates in controlled release matrices are provided which allow sustained concentrations of therapeutic agents within a treated area for a prolonged period. The polymeric drug conjugates hydrolytically degrade in the extracellular space in a controlled, pre-specified pattern, releasing active drug. The conjugates diffuse within the tissue reaching a greater distance from the matrix than free drug would, because of their reduced rate of clearance from the tissue via the capillary system.

    Abstract translation: 提供控制释放基质中的聚合物药物偶联物，其允许治疗区域内持续浓度的治疗剂长时间。 聚合物药物缀合物在受控的预先规定的模式中在细胞外空间中水解降解，释放活性药物。 由于它们通过毛细管系统从组织中的清除率降低，所以组合物在组织内扩散到与基质相比比自由药物更大的距离。

    SYSTEMS AND METHODS FOR MAKING AND USING ENHANCED ELECTRODES FOR ELECTRICAL STIMULATION SYSTEMS
    8.
    发明申请
    SYSTEMS AND METHODS FOR MAKING AND USING ENHANCED ELECTRODES FOR ELECTRICAL STIMULATION SYSTEMS 有权
    用于电刺激系统制造和使用增强电极的系统和方法

    公开(公告)号：US20120053645A1

    公开(公告)日：2012-03-01

    申请号：US13220037

    申请日：2011-08-29

    Applicant: Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Marker

    Inventor： Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Marker

    IPC: A61N1/04 ,  A61N1/36

    CPC classification number: A61N1/05 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36096

    Abstract: A lead assembly for providing electrical stimulation of patient tissue includes at least one elongated lead body, each of the at least one lead bodies having a distal end and a proximal end. A plurality of electrodes are disposed at the distal end of the at least one lead body, each of the electrodes having an outer surface. A plurality of dimples are defined along the outer surface of at least one of the plurality of electrodes, the plurality of dimples configured and arranged to provide a larger surface area for the at least one dimpled electrode than that of a similarly-sized electrode with a flat outer surface. A plurality of terminal are disposed at the proximal end of the at least one lead body. A plurality of conductive wires couple each of the plurality of electrodes to at least one of the plurality of terminals.

    Abstract translation: 用于提供对患者组织的电刺激的引线组件包括至少一个细长引线体，所述至少一个引线体中的每一个具有远端和近端。 多个电极设置在至少一个引线体的远端处，每个电极具有外表面。 沿着多个电极中的至少一个电极的外表面限定多个凹坑，所述多个凹坑被配置和布置成为至少一个凹凸电极提供比具有相同尺寸的电极的更大的表面积 平坦的外表面。 多个端子设置在至少一个引线体的近端处。 多个导线将多个电极中的每一个耦合到多个端子中的至少一个。

    Compliant stimulating electrodes and leads and methods of manufacture and use
    10.
    发明申请
    Compliant stimulating electrodes and leads and methods of manufacture and use 有权
    符合刺激电极和引线以及制造和使用的方法

    公开(公告)号：US20060247749A1

    公开(公告)日：2006-11-02

    申请号：US11120526

    申请日：2005-05-02

    Applicant: Michael Colvin

    Inventor： Michael Colvin

    IPC: A61N1/05

    CPC classification number: A61N1/05 ,  A61L31/14 ,  A61L31/145

    Abstract: A device for stimulating body tissue includes a lead body and at least one stimulating electrode disposed on the lead body. The lead body is configured and arranged to be substantially rigid outside the patient's body and during insertion into the patient's body and then becomes non-rigid upon exposure within the patient's body;.

    Abstract translation: 用于刺激身体组织的装置包括引线体和设置在引线主体上的至少一个刺激电极。 引线体构造和布置成在患者身体外部和插入患者体内时基本上刚性，并且随后在患者体内暴露时变得非刚性。

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