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    SYSTEMS AND METHODS FOR MAKING AND USING ENHANCED ELECTRODES FOR ELECTRICAL STIMULATION SYSTEMS
    1.
    发明申请
    SYSTEMS AND METHODS FOR MAKING AND USING ENHANCED ELECTRODES FOR ELECTRICAL STIMULATION SYSTEMS 有权
    用于电刺激系统制造和使用增强电极的系统和方法

    公开(公告)号：US20120053645A1

    公开(公告)日：2012-03-01

    申请号：US13220037

    申请日：2011-08-29

    Applicant: Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Marker

    Inventor： Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Marker

    IPC: A61N1/04 ,  A61N1/36

    CPC classification number: A61N1/05 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36096

    Abstract: A lead assembly for providing electrical stimulation of patient tissue includes at least one elongated lead body, each of the at least one lead bodies having a distal end and a proximal end. A plurality of electrodes are disposed at the distal end of the at least one lead body, each of the electrodes having an outer surface. A plurality of dimples are defined along the outer surface of at least one of the plurality of electrodes, the plurality of dimples configured and arranged to provide a larger surface area for the at least one dimpled electrode than that of a similarly-sized electrode with a flat outer surface. A plurality of terminal are disposed at the proximal end of the at least one lead body. A plurality of conductive wires couple each of the plurality of electrodes to at least one of the plurality of terminals.

    Abstract translation: 用于提供对患者组织的电刺激的引线组件包括至少一个细长引线体，所述至少一个引线体中的每一个具有远端和近端。 多个电极设置在至少一个引线体的远端处，每个电极具有外表面。 沿着多个电极中的至少一个电极的外表面限定多个凹坑，所述多个凹坑被配置和布置成为至少一个凹凸电极提供比具有相同尺寸的电极的更大的表面积 平坦的外表面。 多个端子设置在至少一个引线体的近端处。 多个导线将多个电极中的每一个耦合到多个端子中的至少一个。

    Systems and methods for making and using enhanced electrodes for electrical stimulation systems
    2.
    发明授权
    Systems and methods for making and using enhanced electrodes for electrical stimulation systems 有权
    制造和使用电刺激系统的增强电极的系统和方法

    公开(公告)号：US08504171B2

    公开(公告)日：2013-08-06

    申请号：US13220037

    申请日：2011-08-29

    Applicant: Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Barker

    Inventor： Vipin Ayanoor-Vitikkate ,  Anne Margaret Pianca ,  Michael Colvin ,  John Michael Barker

    IPC: A61N1/05

    CPC classification number: A61N1/05 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36096

    Abstract: A lead assembly for providing electrical stimulation of patient tissue includes at least one elongated lead body, each of the at least one lead bodies having a distal end and a proximal end. A plurality of electrodes are disposed at the distal end of the at least one lead body, each of the electrodes having an outer surface. A plurality of dimples are defined along the outer surface of at least one of the plurality of electrodes, the plurality of dimples configured and arranged to provide a larger surface area for the at least one dimpled electrode than that of a similarly-sized electrode with a flat outer surface. A plurality of terminal are disposed at the proximal end of the at least one lead body. A plurality of conductive wires couple each of the plurality of electrodes to at least one of the plurality of terminals.

    Abstract translation: 用于提供对患者组织的电刺激的引线组件包括至少一个细长引线体，所述至少一个引线体中的每一个具有远端和近端。 多个电极设置在至少一个引线体的远端，每个电极具有外表面。 沿着多个电极中的至少一个电极的外表面限定多个凹坑，所述多个凹坑被配置和布置成为至少一个凹凸电极提供比具有相同尺寸的电极的更大的表面积 平坦的外表面。 多个端子设置在至少一个引线体的近端处。 多个导线将多个电极中的每一个耦合到多个端子中的至少一个。

    Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces
    3.
    发明申请
    Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权

    公开(公告)号：US20050193860A1

    公开(公告)日：2005-09-08

    申请号：US11096818

    申请日：2005-03-31

    Applicant: Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

    Inventor： Joseph Schulman ,  Charles Byers ,  Gerald Adomian ,  Michael Colvin

    IPC: A61B5/00 ,  C22B4/00 ,  C21C5/52

    CPC classification number: A61B5/14865 ,  A61B5/14532

    Abstract: An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

    Compliant stimulating electrodes and leads and methods of manufacture and use
    6.
    发明申请
    Compliant stimulating electrodes and leads and methods of manufacture and use 有权
    符合刺激电极和引线以及制造和使用的方法

    公开(公告)号：US20060247749A1

    公开(公告)日：2006-11-02

    申请号：US11120526

    申请日：2005-05-02

    Applicant: Michael Colvin

    Inventor： Michael Colvin

    IPC: A61N1/05

    CPC classification number: A61N1/05 ,  A61L31/14 ,  A61L31/145

    Abstract: A device for stimulating body tissue includes a lead body and at least one stimulating electrode disposed on the lead body. The lead body is configured and arranged to be substantially rigid outside the patient's body and during insertion into the patient's body and then becomes non-rigid upon exposure within the patient's body;.

    Abstract translation: 用于刺激身体组织的装置包括引线体和设置在引线主体上的至少一个刺激电极。 引线体构造和布置成在患者身体外部和插入患者体内时基本上刚性，并且随后在患者体内暴露时变得非刚性。

    Hermetic implantable stimulator
    7.
    发明申请
    Hermetic implantable stimulator 失效
    密封植入式刺激器

    公开(公告)号：US20060200200A1

    公开(公告)日：2006-09-07

    申请号：US11073290

    申请日：2005-03-04

    Applicant: Zdzislaw Malinowski ,  Michael Colvin ,  Leslie Halberg

    Inventor： Zdzislaw Malinowski ,  Michael Colvin ,  Leslie Halberg

    IPC: A61N1/00

    CPC classification number: A61N1/37229 ,  A61N1/025 ,  A61N1/375 ,  A61N1/3758 ,  H05K3/284

    Abstract: An implantable medical device, e.g., an implantable pulse generator, having a non-metal sealed housing and method of making same. An exemplary embodiment of the device includes a replenishable power source, coupling electronic components configured to generate a pulse signal to the replenishable power source, and an inorganic coating covering the electronic components and the power source to seal, preferably hermetically, the electronic components and the power source from a body environment.

    Abstract translation: 一种具有非金属密封外壳的可植入医疗装置，例如可植入式脉冲发生器及其制造方法。 该装置的示例性实施例包括可补充电源，耦合被配置为向可补充电源产生脉冲信号的电子部件，以及覆盖电子部件和电源的无机涂层，优选气密地密封电子部件和 来自身体环境的电源。

    Stabilization of hydrogen peroxide in acidic baths for cleaning metals
    8.
    发明授权
    Stabilization of hydrogen peroxide in acidic baths for cleaning metals 失效
    在酸性浴中稳定过氧化氢以清洁金属

    公开(公告)号：US06803354B2

    公开(公告)日：2004-10-12

    申请号：US10212977

    申请日：2002-08-05

    Applicant: Michael Colvin

    Inventor： Michael Colvin

    IPC: C11D1402

    CPC classification number: C01B15/037 ,  C11D3/394 ,  C11D7/3281 ,  C11D7/34 ,  C11D11/0029 ,  C23G1/103

    Abstract: Aqueous acidic solutions of hydrogen peroxide used for metal surface treatments may be stabilized to decrease the rate of hydrogen peroxide decomposition by the use of an aryl sulfonic acid such as phenol sulfonic acid in combination with a triazole such as tolyltriazole.

    Abstract translation: 用于金属表面处理的过氧化氢的酸性水溶液可以被稳定，以通过使用诸如苯酚磺酸的芳基磺酸与三唑如甲苯基三唑的组合来降低过氧化氢分解的速率。

    Implantable microstimulator with plastic housing and methods of manufacture and use
    9.
    发明申请
    Implantable microstimulator with plastic housing and methods of manufacture and use 有权
    具有塑料外壳的可植入微型激励器及其制造和使用方法

    公开(公告)号：US20060161204A1

    公开(公告)日：2006-07-20

    申请号：US11040209

    申请日：2005-01-20

    Applicant: Michael Colvin ,  Tom He ,  Matt Haller

    Inventor： Michael Colvin ,  Tom He ,  Matt Haller

    IPC: A61N1/00

    CPC classification number: A61N1/3752 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/37211

    Abstract: An implantable microstimulator includes a plastic housing having a first end and a second end; an electronic subassembly disposed within the housing; a first electrode disposed at the first end of the plastic housing and in electrical communication with the electronic subassembly; and a second electrode disposed at the second end of the plastic housing and in electrical communication with the electronic subassembly. The plastic housing, first electrode, and second electrode form a hermetically sealed structure around the electronic subassembly.

    Abstract translation: 可植入微型激励器包括具有第一端和第二端的塑料壳体; 设置在所述壳体内的电子组件; 第一电极，设置在塑料外壳的第一端并与电子子组件电连通; 以及设置在所述塑料壳体的第二端并与所述电子子组件电连通的第二电极。 塑料外壳，第一电极和第二电极在电子组件周围形成密封结构。

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