中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.015 seconds)

    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods
    2.
    发明申请
    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods 有权

    公开(公告)号：US20210331178A1

    公开(公告)日：2021-10-28

    申请号：US17195206

    申请日：2021-03-08

    Applicant: Pattern Bioscience, Inc.

    Inventor： Ross Johnson ,  Jonathan Isom ,  David Bussian ,  Nicolas Arab

    IPC: B01L9/00 ,  B01L1/02 ,  G01N21/31 ,  B01L3/00

    Abstract: An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).

    Microfluidic Chips Including a Gutter to Facilitate Loading Thereof and Related Methods
    3.
    发明申请
    Microfluidic Chips Including a Gutter to Facilitate Loading Thereof and Related Methods 有权

    公开(公告)号：US20210053064A1

    公开(公告)日：2021-02-25

    申请号：US16998672

    申请日：2020-08-20

    Applicant: Pattern Bioscience, Inc.

    Inventor： Ross Johnson

    IPC: B01L3/00

    Abstract: A microfluidic chip can comprise a body and a microfluidic network defined by the body. The network can include one or more inlet ports, a test volume, and one or more flow paths extending between the inlet port(s) and the test volume. Along each of the flow path(s), fluid is permitted to flow from one of the inlet port(s), through at least one droplet-generating region in which a minimum cross-sectional area of the flow path increases along the flow path, and to the test volume. The network can include a gutter disposed along at least a portion of a periphery of the test volume such that fluid from the flow path(s) is not permitted to flow into the gutter without flowing through the test volume, wherein, along the gutter, a depth of the gutter is at least 10% larger than the depth of the test volume at the periphery.

    Droplet-generating microfluidic chips and related methods
    4.
    发明授权
    Droplet-generating microfluidic chips and related methods 有权

    公开(公告)号：US10792659B2

    公开(公告)日：2020-10-06

    申请号：US16795337

    申请日：2020-02-19

    Applicant: Pattern Bioscience, Inc.

    Inventor： Ross Johnson

    IPC: B01L99/00 ,  B01L3/00

    Abstract: A microfluidic chip that can have a body defining a microfluidic network including a test volume, one or more ports, and one or more channels in fluid communication between the port(s) and the test volume. Gas can be removed from the test volume before a sample liquid is introduced therein by reducing pressure at a first one of the port(s), optionally while the liquid is disposed in the port. Liquid in the first port can be introduced into the test volume by increasing pressure at the first port. The microfluidic network can define one or more droplet-generating regions in which at least one of the channel(s) defines a constriction and/or two or more of the channels connect at a junction. Liquid flowing from the first port can pass through at least one of the droplet-generating region(s) and to the test volume.

    METHODS FOR PREVENTING INTER-DROPLET TRANSFER OF A FLUORESCENT PRODUCT IN AQUEOUS DROPLETS BY FORMING A SOLUBLE COMPLEX WITH CYCLODEXTRIN
    5.
    发明申请
    METHODS FOR PREVENTING INTER-DROPLET TRANSFER OF A FLUORESCENT PRODUCT IN AQUEOUS DROPLETS BY FORMING A SOLUBLE COMPLEX WITH CYCLODEXTRIN 有权

    公开(公告)号：US20240401020A1

    公开(公告)日：2024-12-05

    申请号：US18699193

    申请日：2022-10-06

    Applicant: PATTERN BIOSCIENCE, INC.

    Inventor： Ross JOHNSON

    IPC: C12N11/04 ,  C09K11/06

    Abstract: A method for retaining fluorescent molecules within aqueous droplets suspended in an emulsion includes combining a plurality of living cells, a plurality of fluorescent molecules, and a plurality of cyclodextrin molecules in an aqueous solution. The method also includes emulsifying the aqueous solution with a hydrophobic fluid to form the aqueous droplets. At least one of the aqueous droplets includes (i) a single living cell or a single cell species in a homogenous aggregate of the plurality of living cells, (ii) at least one fluorescent molecule of the plurality of fluorescent molecules, and (iii) at least one cyclodextrin molecule of the plurality of cyclodextrin molecules.

    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods
    8.
    发明申请
    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods 有权

    公开(公告)号：US20250010305A1

    公开(公告)日：2025-01-09

    申请号：US18898377

    申请日：2024-09-26

    Applicant: Pattern Bioscience, Inc.

    Inventor： Ross Johnson ,  Jonathan Isom ,  David Bussian ,  Nicolas Arab

    IPC: B01L9/00 ,  B01L1/02 ,  B01L3/00 ,  G01N21/31

    Abstract: An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).

Patent Agency Ranking