公开(公告)号：US20090221715A1

公开(公告)日：2009-09-03

申请号：US12394419

申请日：2009-02-27

Applicant: Ashok Kumar ,  Suneel Yeshwant Dike ,  Pramilkumar Mathur ,  Nellithanath Thankachen Byju ,  Brajesh Sharma ,  Swapnil Shreekant Kore ,  Vitthal Suryabhan Buchude ,  Dharmendra Singh

Inventor： Ashok Kumar ,  Suneel Yeshwant Dike ,  Pramilkumar Mathur ,  Nellithanath Thankachen Byju ,  Brajesh Sharma ,  Swapnil Shreekant Kore ,  Vitthal Suryabhan Buchude ,  Dharmendra Singh

IPC: A61K31/122 ,  C07C49/303

CPC classification number: C07C50/32

Abstract: The present invention relates to a novel polymorphic form of atovaquone. More particularly, it relates to a novel crystalline form, that has improved solubility and other bulk characteristics suitable for pharmaceutical application. The present invention also relates to processes for preparing a new polymorphic form of atovaquone and its use in industry.

Abstract translation: 本发明涉及一种新的多形酮多形态。 更具体地说，本发明涉及一种新颖的结晶形式，其具有改善的适用于药物应用的溶解度和其它体积特征。 本发明还涉及制备新戊酰多新异构体形式及其在工业中的应用的方法。

公开(公告)号：US20120136062A1

公开(公告)日：2012-05-31

申请号：US13388729

申请日：2010-08-20

Applicant: Ashok Kumar ,  Dharmendra Singh ,  Pramilkumar Mathur ,  Vitthal Syryabhan Buchude

Inventor： Ashok Kumar ,  Dharmendra Singh ,  Pramilkumar Mathur ,  Vitthal Syryabhan Buchude

IPC: A61K31/155 ,  A61P33/06 ,  A61P33/02 ,  C07C279/18

CPC classification number: C07C279/26 ,  C07C50/32

Abstract: Disclosed are complexes of an antipneumocystic compound and an antimalarial compound, processes for their preparation, pharmaceutical compositions and methods of using said complexes or compositions for the treatment and/or prophylaxis of parasitic infections.

Abstract translation: 公开了抗肺囊虫化合物和抗疟疾化合物的复合物，其制备方法，药物组合物和使用所述复合物或组合物用于治疗和/或预防寄生虫感染的方法。

公开(公告)号：US08987234B2

公开(公告)日：2015-03-24

申请号：US13388729

申请日：2010-08-20

Applicant: Ashok Kumar ,  Dharmendra Singh ,  Pramilkumar Mathur ,  Vitthal Syryabhan Buchude

Inventor： Ashok Kumar ,  Dharmendra Singh ,  Pramilkumar Mathur ,  Vitthal Syryabhan Buchude

IPC: A01N37/36 ,  C07C279/26 ,  C07C50/32

CPC classification number: C07C279/26 ,  C07C50/32

Abstract: Disclosed are complexes of an antipneumocystic compound and an antimalarial compound, processes for their preparation, pharmaceutical compositions and methods of using said complexes or compositions for the treatment and/or prophylaxis of parasitic infections.

Abstract translation: 公开了抗肺囊虫化合物和抗疟疾化合物的复合物，其制备方法，药物组合物和使用所述复合物或组合物用于治疗和/或预防寄生虫感染的方法。

公开(公告)号：US20100081847A1

公开(公告)日：2010-04-01

申请号：US12603253

申请日：2009-10-21

Applicant: Ashok Kumar ,  Suneel Yeshwant Dike ,  Pramilkumar Mathur ,  Nellithanath Thankachen Byju ,  Brajesh Sharma ,  Swapnil Shreekant Kore ,  Vitthal Suryabhan Buchude ,  Dharmendra Singh

Inventor： Ashok Kumar ,  Suneel Yeshwant Dike ,  Pramilkumar Mathur ,  Nellithanath Thankachen Byju ,  Brajesh Sharma ,  Swapnil Shreekant Kore ,  Vitthal Suryabhan Buchude ,  Dharmendra Singh

IPC: C07C49/603 ,  C07C45/61 ,  C07C45/67

CPC classification number: C07C49/697 ,  C07C45/63 ,  C07C46/00 ,  C07C50/24 ,  C07C50/32

Abstract: Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.

Abstract translation: 本文公开了一种制备阿托瓦醌的新方法。 该方法包括使1,4-萘醌与反式-4-（4-氯苯基）环己烷羧酸反应，然后卤化，得到二卤代化合物。 此外，二卤化合物的脱卤化氢产生一种单卤代化合物，其在水解下产生阿托喹醌。 本发明还公开了一种基本纯净且明确定义的多晶型形式的阿托伐醌，称为“形式IPCA-ATO”及其制备。