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公开(公告)号：US08846961B2
公开(公告)日：2014-09-30
申请号：US13877211
申请日：2011-09-29
Applicant: Raphael Beumer
Inventor： Raphael Beumer
IPC: C07B33/00 , C07C51/16 , C07C45/51 , C07C253/30
CPC classification number: C07C51/16 , C07C45/513 , C07C253/30 , C07C49/203 , C07C255/07
Abstract: The present invention relates to a new and improved synthesis of peretinoin.
Abstract translation: 本发明涉及一种新的和改进的甜菜碱的合成。
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公开(公告)号：US20070270472A1
公开(公告)日：2007-11-22
申请号：US11631322
申请日：2005-07-01
Applicant: Raphael Beumer , Jochen Klock , Juergen Vollhardt , Philippe Maillan , Stefan Stoeckli
Inventor： Raphael Beumer , Jochen Klock , Juergen Vollhardt , Philippe Maillan , Stefan Stoeckli
IPC: A61K31/20 , A61K31/40 , A61K31/4172 , A61K31/44 , A61Q19/00 , C07C233/00 , C07D207/02 , C07D213/60 , C07D233/66
CPC classification number: C07D233/64 , A61K8/671 , A61Q19/00 , A61Q19/08 , C07C403/20 , C07C2601/16 , C07D207/16 , C07D213/65
Abstract: The invention provides the use of retinoyl derivatives for the cosmetic treatment or prophylaxis of wrinkles, skin aging and/or for thickening the epidermis.
Abstract translation: 本发明提供了视黄酰基衍生物用于化妆品处理或预防皱纹，皮肤老化和/或增厚表皮的用途。
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3.发明申请Composition comprising an HDAC inhibitor in combination with a retinoid 审中-公开组合物，其包含与类视黄醇组合的HDAC抑制剂公开(公告)号：US20100286278A1
公开(公告)日：2010-11-11
申请号：US12801347
申请日：2010-06-04
Applicant: Volker Schehlmann , Jochen Klock , Philippe Emmanuel Maillan , Juergen H. Vollhardt , Anthony Rawlings , Raphael Beumer
Inventor： Volker Schehlmann , Jochen Klock , Philippe Emmanuel Maillan , Juergen H. Vollhardt , Anthony Rawlings , Raphael Beumer
IPC: A61K31/192 , A61P17/10 , A61P17/04 , A61Q19/00 , A61Q19/08 , A61P17/14 , A61K8/36 , A61K31/165 , A61K8/42 , A61K31/17
CPC classification number: A61K8/671 , A61K8/36 , A61K8/361 , A61K8/37 , A61K2800/782 , A61Q7/00 , A61Q19/02 , A61Q19/08
Abstract: The present invention is directed to compositions which contain a combination of at least one histone deacetylase inhibitor (HDAC inhibitor) and a retinoid. The composition is in particular a cosmetic preparation. It was found that the combination of an HDAC inhibitor and retinol or a derivative thereof is in particular useful for treating wrinkles but also for thickening the epidermis and for improving hair growth.
Abstract translation: 本发明涉及含有至少一种组蛋白脱乙酰酶抑制剂（HDAC抑制剂）和类维生素A的组合的组合物。 该组合物特别是化妆品制剂。 发现HDAC抑制剂和视黄醇或其衍生物的组合特别可用于治疗皱纹，但也用于增厚表皮和改善毛发生长。
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公开(公告)号：US20090068136A1
公开(公告)日：2009-03-12
申请号：US12281032
申请日：2007-02-23
Applicant: Raphael Beumer , Franciscus Derks , Christine Mendrok
Inventor： Raphael Beumer , Franciscus Derks , Christine Mendrok
CPC classification number: A61K8/88 , A61K8/20 , A61K8/416 , A61K8/463 , A61K8/49 , A61K8/922 , A61K2800/54 , A61Q5/02 , A61Q5/06 , A61Q5/12 , C08G69/44
Abstract: The invention relates to hair care compositions comprising an effective amount of a condensation polymer having at least one, optionally quarternized or protonated, dialkylamide end-group connected through the polymer backbone to a unit derived from an alkylamide, the connection comprising at least one ester linkage.
Abstract translation: 本发明涉及护发组合物，其包含有效量的缩合聚合物，其具有通过聚合物主链连接到源自烷基酰胺的单元的至少一个，任选地季铵化或质子化的二烷基酰胺端基，所述连接包含至少一个酯键 。
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公开(公告)号：US08951560B2
公开(公告)日：2015-02-10
申请号：US11994216
申请日：2006-01-31
Applicant: Juergen H. Vollhardt , Philippe Emmanuel Maillan , Raphael Beumer , Chyi-Cheng Chen , Heinz Gutzwiller , Ernst Zedi
Inventor： Juergen H. Vollhardt , Philippe Emmanuel Maillan , Raphael Beumer , Chyi-Cheng Chen , Heinz Gutzwiller , Ernst Zedi
IPC: A61K9/14 , A61K31/352 , A23K1/16 , A23L1/30 , A61K8/49 , A61K9/10 , A61K9/51 , A61Q19/00 , B82Y5/00 , A61K8/73 , A61K9/107
CPC classification number: A61K31/352 , A23K20/121 , A23L33/105 , A23V2002/00 , A23V2200/25 , A61K8/498 , A61K8/732 , A61K9/10 , A61K9/107 , A61K9/146 , A61K9/5161 , A61K2800/413 , A61Q19/00 , B82Y5/00 , Y10S977/773 , A23V2200/254 , A23V2250/21172 , A23V2250/2116
Abstract: The present invention is directed to isoflavone nanoparticle compositions comprising isoflavone in the form of nanoparticles and preferably a carrier. The isoflavone nanoparticle compositions are particularly useful for preparing cosmetic compositions, pharmaceutical compositions, foodstuff, food and feed additives. In the compositions comprising the isoflavone nanoparticle compositions recrystallization of the isoflavone to bigger particles is retarded.
Abstract translation: 本发明涉及包含纳米颗粒形式的异黄酮和优选载体的异黄酮纳米颗粒组合物。 异黄酮纳米颗粒组合物特别可用于制备化妆品组合物，药物组合物，食品，食品和饲料添加剂。 在包含异黄酮纳米颗粒组合物的组合物中，异黄酮对较大颗粒的重结晶被延迟。
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Patent Agency Ranking
公开(公告)号：US08951509B2
公开(公告)日：2015-02-10
申请号：US12281063
申请日：2007-02-23
Applicant: Raphael Beumer , Franciscus Derks , Christine Mendrok
Inventor： Raphael Beumer , Franciscus Derks , Christine Mendrok
IPC: A61K8/73 , A61K8/04 , A61K8/85 , A61K8/88 , A61Q1/02 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C08G69/44 , C11D3/37
CPC classification number: A61K8/046 , A61K8/85 , A61K8/88 , A61K2800/5426 , A61K2800/57 , A61Q1/02 , A61Q3/02 , A61Q5/006 , A61Q5/008 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C08G69/44 , C11D3/3719
Abstract: The invention relates to novel optionally quaternized or protonated condensation polymers having at least one heterocyclic end-group connected to the polymer backbone through a unit derived from an alkylamide, the connection comprising an optionally substituted ethylene group and to the use thereof in body care products and household products.
Abstract translation: 本发明涉及新颖的具有季铵化或质子化的缩合聚合物，其具有通过衍生自烷基酰胺的单元连接至聚合物主链的至少一个杂环端基，该连接包含任选取代的亚乙基以及其在身体护理产品中的用途，以及 家庭用品。
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公开(公告)号：US08815225B2
公开(公告)日：2014-08-26
申请号：US12281032
申请日：2007-02-23
Applicant: Raphael Beumer , Franciscus Derks , Christine Mendrok
Inventor： Raphael Beumer , Franciscus Derks , Christine Mendrok
CPC classification number: A61K8/88 , A61K8/20 , A61K8/416 , A61K8/463 , A61K8/49 , A61K8/922 , A61K2800/54 , A61Q5/02 , A61Q5/06 , A61Q5/12 , C08G69/44
Abstract: The invention relates to hair care compositions comprising an effective amount of a condensation polymer having at least one, optionally quarternized or protonated, dialkylamide end-group connected through the polymer backbone to a unit derived from an alkylamide, the connection comprising at least one ester linkage.
Abstract translation: 本发明涉及护发组合物，其包含有效量的缩合聚合物，其具有通过聚合物主链连接到源自烷基酰胺的单元的至少一个，任选地季铵化或质子化的二烷基酰胺端基，所述连接包含至少一个酯键 。
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公开(公告)号：US08394855B2
公开(公告)日：2013-03-12
申请号：US13137659
申请日：2011-09-01
Applicant: Raphael Beumer
Inventor： Raphael Beumer
CPC classification number: A61Q19/08 , A61K8/365 , A61K8/671 , A61K31/07 , A61K31/20 , A61K31/203 , A61K2800/75 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/02 , A61Q19/06
Abstract: The present invention is concerned with novel cosmetic or pharmaceutical compositions. More particularly, the invention is concerned with novel cosmetic or pharmaceutical compositions for treating or preventing any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as well as for the promotion of hair growth and protection from hair loss.
Abstract translation: 本发明涉及新颖的化妆品或药物组合物。 更具体地，本发明涉及用于治疗或预防由健康皮肤的生理平衡的负面发展引起的任何症状以及用于促进头发生长和防止脱发的新型化妆品或药物组合物。
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公开(公告)号：US20090041687A1
公开(公告)日：2009-02-12
申请号：US11990389
申请日：2006-09-14
Applicant: Raphael Beumer , Jochen Klock
Inventor： Raphael Beumer , Jochen Klock
CPC classification number: A61Q19/02 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/49 , A61K8/4973 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/343 , A61K31/485 , A61K45/06
Abstract: The present invention relates to a new use of opioid receptor antagonists. More particularly, the present invention relates to the use of opioid receptor antagonists for the manufacture of topical compositions for suppression of melanin formation in the human skin; to topical, particularly cosmetic, compositions for suppression of melanin formation in the human skin comprising an opioid receptor antagonist; and to a method of lightening human skin and/or treatment of pigmentation disorders which comprises topically administering an effective amount of an opioid receptor antagonist to the appropriate skin area of a person in need of such treatment.
Abstract translation: 本发明涉及阿片受体拮抗剂的新用途。 更具体地说，本发明涉及阿片受体拮抗剂在制备用于抑制人皮肤中黑色素形成的局部组合物中的用途; 用于抑制人皮肤中黑色素形成的局部，特别是化妆品组合物，其包含阿片受体拮抗剂; 以及减轻人类皮肤和/或治疗色素沉着病症的方法，其包括将有效量的阿片受体拮抗剂局部给予需要这种治疗的人的适当皮肤区域。
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公开(公告)号：US20080311209A1
公开(公告)日：2008-12-18
申请号：US11994212
申请日：2006-01-31
Applicant: Raphael Beumer , Chyi-Cheng Chen , Heinz Gutzwiller , Philippe Emmanuel Maillan , Markus Nowotny , Bernd Schlegel , Juergen Vollhardt
Inventor： Raphael Beumer , Chyi-Cheng Chen , Heinz Gutzwiller , Philippe Emmanuel Maillan , Markus Nowotny , Bernd Schlegel , Juergen Vollhardt
CPC classification number: A61Q19/00 , A61K8/0241 , A61K8/347 , A61K8/498 , A61K8/732 , A61K9/0014 , A61K9/145 , A61K9/1694 , A61K31/352 , A61K2800/413 , A61Q17/005 , A61Q17/04 , A61Q19/02 , A61Q19/08 , B82Y5/00 , Y10S977/926
Abstract: The present invention is directed to topical compositions, comprising isoflavone nanoparticle compositions. The isoflavone nanoparticle compositions contain isoflavone in the form of nanoparticles and preferably a carrier. In the topical compositions recrystallization of the isoflavone to bigger particles is avoided.
Abstract translation: 本发明涉及包含异黄酮纳米颗粒组合物的局部组合物。 异黄酮纳米颗粒组合物含有纳米颗粒和优选载体形式的异黄酮。 在局部组合物中，避免了将异黄酮重结晶成更大的颗粒。
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