Patent search ap:"Sheldon X. Cao" Page 1

1.

发明授权
Polo-like kinase inhibitors 失效
Title translation: 马球状激酶抑制剂

公开(公告)号：US08318727B2

公开(公告)日：2012-11-27

申请号：US12962557

申请日：2010-12-07

Applicant: Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam

Inventor： Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam

IPC: C07D487/04 , A61K31/55

CPC classification number: C07D487/04 , C07D487/14 , C07D519/00

Abstract: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物用于激酶：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

2.

发明授权
Substituted indazoles as glucokinase activators 失效
Title translation: 取代吲哚作为葡萄糖激酶活化剂

公开(公告)号：US08008332B2

公开(公告)日：2011-08-30

申请号：US11754205

申请日：2007-05-25

Applicant: Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang

Inventor： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang

IPC: A61K31/427 , A61K31/4402 , C07D231/56 , A61K31/4353 , A61K31/519 , A61K31/4995 , C07D487/04 , C07D471/04 , A61P3/10 , A61P9/00

CPC classification number: C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04

Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供了与己糖激酶一起使用的化合物，其包含：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

3.

发明授权
Dipeptidyl peptidase inhibitors 有权
Title translation: 二肽基肽酶抑制剂

公开(公告)号：US07790734B2

公开(公告)日：2010-09-07

申请号：US10934326

申请日：2004-09-02

Applicant: Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang

Inventor： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang

IPC: C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505

CPC classification number: C07D401/04

Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.

Abstract translation: 提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。

4.

发明授权
Kinase inhibitors 失效
Title translation: 激酶抑制剂

公开(公告)号：US07550598B2

公开(公告)日：2009-06-23

申请号：US11208437

申请日：2005-08-18

Applicant: Sheldon X. Cao , Anthony R. Gangloff , Bheema R. Paraselli , Jeffrey A. Stafford , Hasanthi P. Wijesekera

Inventor： Sheldon X. Cao , Anthony R. Gangloff , Bheema R. Paraselli , Jeffrey A. Stafford , Hasanthi P. Wijesekera

IPC: C07D215/38 , A61K38/40

CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound of the formula: wherein R1, R2, R3, Q, U, V, W, X, and Y are as defined herein.

Abstract translation: 提供化合物，药物组合物，试剂盒和方法用于包含下式化合物的激酶：其中R 1，R 2，R 3，Q，U，V，W，X和Y如本文所定义。

5.

发明授权
Substituted isoindoles as glucokinase activators 失效
Title translation: 取代的异吲哚作为葡萄糖激酶激活剂

公开(公告)号：US08394843B2

公开(公告)日：2013-03-12

申请号：US13185166

申请日：2011-07-18

Applicant: Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford

Inventor： Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford

IPC: C07D209/02 , C07D275/02 , A61K31/4035 , A61K31/4168 , C07D231/56 , C07D471/02 , C07D487/04 , A61K31/519 , A61K31/4152 , A61K31/416 , A61K31/437 , A61K31/4985 , A61P13/12

CPC classification number: C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04

Abstract: Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.

Abstract translation: 提供了具有下式的化合物：其中变量如本文所定义。还提供含有这些化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物来激活葡糖激酶的方法。

6.

发明申请
GLUCOKINASE ACTIVATORS 失效

公开(公告)号：US20110275665A1

公开(公告)日：2011-11-10

申请号：US13185166

申请日：2011-07-18

Applicant: Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang

Inventor： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang

IPC: A61K31/437 , A61P3/10 , A61K31/427 , A61P3/08 , C07D417/12 , C07D471/04

CPC classification number: C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04

Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供了与己糖激酶一起使用的化合物，其包含：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

7.

发明申请
GLUCOKINASE ACTIVATORS 审中-公开

公开(公告)号：US20110070297A1

公开(公告)日：2011-03-24

申请号：US12958265

申请日：2010-12-01

Applicant: Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang

Inventor： Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang

IPC: A61K31/5377 , C07D249/12 , A61K31/4196 , A61K9/127 , C07D401/12 , A61K31/4439 , C07D413/12 , C07D231/20 , A61K31/415 , C07D403/10 , C07D403/12 , A61K31/496 , A61K31/4178 , A61K31/506 , A61K31/427 , A61K31/4184 , C07D413/04 , A61K31/423 , C07D471/04 , A61K31/4353 , A61K31/517 , A61P3/10

CPC classification number: C07D249/12 , C07D231/12 , C07D231/20 , C07D249/08 , C07D249/14 , C07D401/04 , C07D401/12 , C07D407/04 , C07D409/12 , C07D417/12

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract translation: 提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的葡糖激酶：其中变量如本文所定义。

8.

发明授权
Histone deacetylase inhibitors 失效
Title translation: 组蛋白脱乙酰酶抑制剂

公开(公告)号：US07381825B2

公开(公告)日：2008-06-03

申请号：US10803575

申请日：2004-03-17

Applicant: Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao

Inventor： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao

IPC: C07D401/04

CPC classification number: C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10

Abstract: Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

Abstract translation: 可用于抑制组氨酸脱乙酰酶的化合物，其具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> ZQLM或ZLM <？in-line-formula description =“In-line 式“end =”tail“？>其中M是能够与脱乙酰酶催化部位和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。