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![Oxaspiro[2.5]Octane Derivatives and Analogs](/abs-image/US/2015/02/12/US20150045427A1/abs.jpg.150x150.jpg)
公开(公告)号：US20150045427A1
公开(公告)日：2015-02-12
申请号：US14003906
申请日：2012-03-07
Applicant: James E. Vath , Stuart Chaffee
Inventor： James E. Vath , Stuart Chaffee
IPC: C07D303/22
CPC classification number: C07D303/46 , C07B59/004 , C07B2200/05 , C07D303/22 , C07D303/32 , C07D303/34 , C07D303/36 , C07D303/38 , C07D303/40 , C07D405/14 , C07D453/02 , C07D491/10 , C07D491/107 , C07D493/10
Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
Abstract translation: 本发明提供氧辛螺[2.5]辛烷衍生物和类似物，其制备方法，其中间体，药物组合物及其在治疗各种障碍和病症如超重和肥胖症中的用途。
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公开(公告)号：US07115617B2
公开(公告)日：2006-10-03
申请号：US10225819
申请日：2002-08-21
Applicant: John L. Buchanan , Stuart Chaffee , Jean-Christophe Harmange , Perry M. Novak , Xiaotian Zhu
Inventor： John L. Buchanan , Stuart Chaffee , Jean-Christophe Harmange , Perry M. Novak , Xiaotian Zhu
IPC: C07D413/12 , A61K31/422 , C07D239/48
CPC classification number: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
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公开(公告)号：US20070072862A1
公开(公告)日：2007-03-29
申请号：US11503551
申请日：2006-08-11
Applicant: Erin Dimauro , Jean Bemis , Stuart Chaffee , Ning Chen , Essu Hu , Roxanne Kunz , Matthew Martin , David McGowan , Shannon Rumfelt
Inventor： Erin Dimauro , Jean Bemis , Stuart Chaffee , Ning Chen , Essu Hu , Roxanne Kunz , Matthew Martin , David McGowan , Shannon Rumfelt
IPC: A61K31/506 , A61K31/502 , A61K31/501 , A61K31/497 , A61K31/498 , A61K31/4745 , A61K31/4709
CPC classification number: C07D213/75 , C07D215/38 , C07D239/42 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, L, R1, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.
Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括自身免疫疾病和炎症的化合物。 在一个实施方案中，化合物具有通式I，其中A 1，A 2，A 3，A 4， >，L，R 1，R 2和R 3在本文中定义。 本发明还包括药物组合物，其包含一种或多种本发明化合物，通过施用本发明化合物来治疗Lck和/或c-Kit激酶介导的疾病的使用方法，或包含一种或多种本发明化合物的组合物 发明，以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US06939874B2
公开(公告)日：2005-09-06
申请号：US10225783
申请日：2002-08-21
Applicant: Jean-Christophe Harmange , John L. Buchanan , Stuart Chaffee , Perry M. Novak , Simon Van Der Plas , Xiaotian Zhu
Inventor： Jean-Christophe Harmange , John L. Buchanan , Stuart Chaffee , Perry M. Novak , Simon Van Der Plas , Xiaotian Zhu
IPC: A61K31/506 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4709
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
Abstract translation: 本发明包括其化合物，类似物，前药和药学上可接受的盐，药物组合物，用途和预防和治疗癌症的方法。
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公开(公告)号：US20070173521A1
公开(公告)日：2007-07-26
申请号：US11599901
申请日：2006-11-14
Applicant: Qiufen Xue , Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Bryant Yang , Wenge Zhong
Inventor： Qiufen Xue , Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Bryant Yang , Wenge Zhong
IPC: A61K31/513 , A61K31/506
CPC classification number: C07D405/12 , C07D413/12
Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1, W, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中R 1，W，B，R 3，R 4，R 4， 5，i和j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。
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Patent Agency Ranking
公开(公告)号：US20060009453A1
公开(公告)日：2006-01-12
申请号：US11126000
申请日：2005-05-09
Applicant: Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
Inventor： Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
IPC: A61K31/53 , A61K31/506 , C07D43/14
CPC classification number: C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
Abstract: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
Abstract translation: 本发明涉及具有通式I的化合物，其中A，B，D，E，G，H 1-5和R 1-4如本文所定义， 和合成中间体，其能够调节各种蛋白激酶受体酶，从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如，这些化合物能够调节激酶，从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。 本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。
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![Oxaspiro[2.5]octane derivatives and analogs](/abs-image/US/2016/05/03/US09328082B2/abs.jpg.150x150.jpg)
公开(公告)号：US09328082B2
公开(公告)日：2016-05-03
申请号：US14003906
申请日：2012-03-07
Applicant: James E. Vath , Stuart Chaffee
Inventor： James E. Vath , Stuart Chaffee
IPC: C07D303/22 , A61K31/336 , C07D303/32 , C07D303/34 , C07D303/36 , C07D405/14 , C07D453/02 , C07D491/10 , C07D493/10
CPC classification number: C07D303/46 , C07B59/004 , C07B2200/05 , C07D303/22 , C07D303/32 , C07D303/34 , C07D303/36 , C07D303/38 , C07D303/40 , C07D405/14 , C07D453/02 , C07D491/10 , C07D491/107 , C07D493/10
Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
Abstract translation: 本发明提供氧辛螺[2.5]辛烷衍生物和类似物，其制备方法，其中间体，药物组合物及其在治疗各种障碍和病症如超重和肥胖症中的用途。
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公开(公告)号：US20070185144A1
公开(公告)日：2007-08-09
申请号：US11595187
申请日：2006-11-10
Applicant: Wenge Zhong , Stephen Hitchcock , Brian Albrecht , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Dean Hickman , Daniel Horne , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang
Inventor： Wenge Zhong , Stephen Hitchcock , Brian Albrecht , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Dean Hickman , Daniel Horne , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Qiufen Xue , Bryant Yang
IPC: A61K31/4747 , A61K31/4743 , A61K31/4741 , A61K31/4025 , A61K31/353 , A61K31/277 , A61K31/165 , C07D491/02
CPC classification number: C07D405/12 , C07D311/68 , C07D413/12 , C07D491/052
Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，W，R 3，R 4，R 5，i和 j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US20070185103A1
公开(公告)日：2007-08-09
申请号：US11600264
申请日：2006-11-14
Applicant: Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Quifen Xue , Bryant Yang , Wenge Zhong
Inventor： Brian Albrecht , Denise Andersen , Michael Bartberger , James Brown , Ryan Brown , Stuart Chaffee , Yuan Cheng , Michael Croghan , Russell Graceffa , Scott Harried , Stephen Hitchcock , Randall Hungate , Ted Judd , Matthew Kaller , Charles Kreiman , Daniel La , Patricia Lopez , Craig Masse , Holger Monenschein , Thomas Nguyen , Thomas Nixey , Vinod Patel , Lewis Pennington , Matthew Weiss , Quifen Xue , Bryant Yang , Wenge Zhong
IPC: A61K31/538 , A61K31/503 , A61K31/4704 , A61K31/4745 , A61K31/4188 , A61K31/4162 , C07D487/02 , C07D471/02
CPC classification number: C07D405/12 , C07D413/12
Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j分别为 本文定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。
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公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
Applicant: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
Inventor： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC: A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC classification number: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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