公开(公告)号：US20200246222A1

公开(公告)日：2020-08-06

申请号：US16782628

申请日：2020-02-05

Applicant: TearClear Corp.

Inventor： Michael T. MALANGA ,  Howard L. GOLUB

IPC: A61J1/14 ,  A61K9/00 ,  B01D39/16 ,  A61K47/18 ,  A61K47/40 ,  A61K31/5575 ,  A61K31/573 ,  A61K38/13

Abstract: Systems and methods for removing a preservative from a solution, emulsion, or suspension may include an ophthalmic agent, a complexing agent, and a matrix. A method for administering an ophthalmic agent may include: providing a solution, emulsion, or suspension comprising a hydrophobic ophthalmic agent, a preservative, and a complexing agent, wherein the complexing agent is configured to host the hydrophobic ophthalmic agent; and providing a polymeric matrix, wherein the complexing agent is configured to reduce an affinity of the ophthalmic agent for the polymeric matrix and wherein the polymeric matrix is configured to selectively absorb the preservative when the solution, emulsion, or suspension is passed therethrough.

公开(公告)号：US11564832B2

公开(公告)日：2023-01-31

申请号：US16833368

申请日：2020-03-27

Applicant: TearClear Corp.

Inventor： Howard L. Golub ,  Srini Venkatesh ,  Edward Browka ,  Joe Ranalletta ,  Eli Nichols ,  Peter Smith ,  Theodore Mosler ,  Kristin Benokraitis

IPC: A61F9/00

Abstract: A flow control device for a compressible bottle may include a reservoir, the reservoir comprising an ophthalmic formulation disposed therein, the ophthalmic formulation comprising an ophthalmic agent and a preservative; a reservoir interface, disposed at a mouth of the reservoir, the reservoir interface comprising one or more apertures, the one or more apertures in the reservoir interface fluidically connecting an interior of the reservoir and an exterior of the reservoir; a nozzle, the nozzle comprising: an outlet and a nozzle cap, the nozzle cap comprising one or more apertures, the one or more apertures in the nozzle cap fluidically connecting the outlet and a reservoir-facing surface of the nozzle; and an axis of rotation, wherein rotation of the nozzle about the axis of rotation relative to the reservoir aligns the one or more apertures in the reservoir interface with the one or more apertures in the nozzle cap.

公开(公告)号：US20240173208A1

公开(公告)日：2024-05-30

申请号：US18215733

申请日：2023-06-28

Applicant: TearClear Corp.

Inventor： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC: A61J1/14 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/26 ,  B01J20/28 ,  A61F9/00

CPC classification number: A61J1/1456 ,  A61J1/1468 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  A61F9/0008 ,  B01J2220/52 ,  B01J2220/56

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20200346186A1

公开(公告)日：2020-11-05

申请号：US16862918

申请日：2020-04-30

Applicant: TearClear Corp.

Inventor： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC: B01J20/26 ,  B01J20/28 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/382 ,  A61K31/517

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20190307641A1

公开(公告)日：2019-10-10

申请号：US16376387

申请日：2019-04-05

Applicant: TearClear Corp. ,  University of Florida Research Foundation, Incorporated

Inventor： Howard L. GOLUB ,  Anuj CHAUHAN ,  Michael WILLIAMS

IPC: A61J1/14 ,  A61F9/00 ,  B65D47/06 ,  B65D25/42 ,  B05B1/14 ,  B05B1/34 ,  B65D41/20 ,  B65D35/28

Abstract: The present disclosure relates to nozzles for removing a preservative from a fluid comprising a therapeutic agent to an eye. More particularly, the nozzles disclosed herein may minimize patient exposure to preservative by rapidly and selectively removing a preservative from a solution comprising a therapeutic agent. An example nozzle may comprise a flow diverter which directs a flow path from a fluid inlet to a fluid outlet over a length longer than the distance from the inlet to the outlet. In some cases, the nozzle may comprise a preservative removing agent.

公开(公告)号：US11963906B2

公开(公告)日：2024-04-23

申请号：US18086847

申请日：2022-12-22

Applicant: TearClear Corp.

Inventor： Howard L. Golub ,  Srini Venkatesh ,  Edward Browka ,  Joe Ranalletta ,  Eli Nichols ,  Peter Smith ,  Theodore Mosler ,  Kristin Benokraitis

IPC: A61F9/00

CPC classification number: A61F9/0008

Abstract: A flow control device for a compressible bottle may include a reservoir, the reservoir comprising an ophthalmic formulation disposed therein, the ophthalmic formulation comprising an ophthalmic agent and a preservative; a reservoir interface, disposed at a mouth of the reservoir, the reservoir interface comprising one or more apertures, the one or more apertures in the reservoir interface fluidically connecting an interior of the reservoir and an exterior of the reservoir; a nozzle, the nozzle comprising: an outlet and a nozzle cap, the nozzle cap comprising one or more apertures, the one or more apertures in the nozzle cap fluidically connecting the outlet and a reservoir-facing surface of the nozzle; and an axis of rotation, wherein rotation of the nozzle about the axis of rotation relative to the reservoir aligns the one or more apertures in the reservoir interface with the one or more apertures in the nozzle cap.

公开(公告)号：US11723838B2

公开(公告)日：2023-08-15

申请号：US16862918

申请日：2020-04-30

Applicant: TearClear Corp.

Inventor： Michael Wilson ,  Michael Williams ,  Deniz Hay ,  Michael Malanga

IPC: A61J1/14 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/28 ,  B01J20/26 ,  A61F9/00

CPC classification number: A61J1/1456 ,  A61J1/1468 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  A61F9/0008 ,  B01J2220/52 ,  B01J2220/56

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US11179294B2

公开(公告)日：2021-11-23

申请号：US17200595

申请日：2021-03-12

Applicant: TearClear Corp.

Inventor： Michael S. Williams ,  Deniz Hay

IPC: A61J1/14 ,  A61K9/00 ,  A61K9/08 ,  A61K47/18 ,  B01D67/00 ,  B01D69/14 ,  B01D71/26 ,  B01J20/26 ,  B01J20/28

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a hydrophobic polymer/fatty acid blend. The microparticles of hydrophobic polymer/fatty acid blend selectively absorb preservative allowing the drug to remain in solution for delivery.

公开(公告)号：US11045390B2

公开(公告)日：2021-06-29

申请号：US16376387

申请日：2019-04-05

Applicant: TearClear Corp. ,  University of Florida Research Foundation, Incorporated

Inventor： Howard L. Golub ,  Anuj Chauhan ,  Michael Williams

IPC: A61F9/00 ,  A61J1/14 ,  B65D47/06 ,  B65D25/42 ,  B05B1/34 ,  B65D41/20 ,  B65D35/28 ,  B05B1/14

Abstract: The present disclosure relates to nozzles for removing a preservative from a fluid comprising a therapeutic agent to an eye. More particularly, the nozzles disclosed herein may minimize patient exposure to preservative by rapidly and selectively removing a preservative from a solution comprising a therapeutic agent. An example nozzle may comprise a flow diverter which directs a flow path from a fluid inlet to a fluid outlet over a length longer than the distance from the inlet to the outlet. In some cases, the nozzle may comprise a preservative removing agent.

公开(公告)号：US20200337895A1

公开(公告)日：2020-10-29

申请号：US16833368

申请日：2020-03-27

Applicant: TearClear Corp.

Inventor： Howard L. GOLUB ,  Srini VENKATESH ,  Edward BROWKA ,  Joe RANALLETTA ,  Eli NICHOLS ,  Peter SMITH ,  Theodore MOSLER ,  Kristin BENOKRAITIS

IPC: A61F9/00

Abstract: A flow control device for a compressible bottle may include a reservoir, the reservoir comprising an ophthalmic formulation disposed therein, the ophthalmic formulation comprising an ophthalmic agent and a preservative; a reservoir interface, disposed at a mouth of the reservoir, the reservoir interface comprising one or more apertures, the one or more apertures in the reservoir interface fluidically connecting an interior of the reservoir and an exterior of the reservoir; a nozzle, the nozzle comprising: an outlet and a nozzle cap, the nozzle cap comprising one or more apertures, the one or more apertures in the nozzle cap fluidically connecting the outlet and a reservoir-facing surface of the nozzle; and an axis of rotation, wherein rotation of the nozzle about the axis of rotation relative to the reservoir aligns the one or more apertures in the reservoir interface with the one or more apertures in the nozzle cap.