公开(公告)号：US20240173208A1

公开(公告)日：2024-05-30

申请号：US18215733

申请日：2023-06-28

Applicant: TearClear Corp.

Inventor： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC: A61J1/14 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/26 ,  B01J20/28 ,  A61F9/00

CPC classification number: A61J1/1456 ,  A61J1/1468 ,  A61K31/382 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/5383 ,  B01D71/26 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  A61F9/0008 ,  B01J2220/52 ,  B01J2220/56

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20200346186A1

公开(公告)日：2020-11-05

申请号：US16862918

申请日：2020-04-30

Applicant: TearClear Corp.

Inventor： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC: B01J20/26 ,  B01J20/28 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/382 ,  A61K31/517

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20210196569A1

公开(公告)日：2021-07-01

申请号：US17200595

申请日：2021-03-12

Applicant: TearClear Corp.

Inventor： Michael S. WILLIAMS ,  Deniz HAY

IPC: A61J1/14 ,  A61K9/00 ,  A61K9/08 ,  A61K47/18 ,  B01D67/00 ,  B01D69/14 ,  B01D71/26 ,  B01J20/26 ,  B01J20/28

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a hydrophobic polymer/fatty acid blend. The microparticles of hydrophobic polymer/fatty acid blend selectively absorb preservative allowing the drug to remain in solution for delivery.

公开(公告)号：US20200345583A1

公开(公告)日：2020-11-05

申请号：US16932623

申请日：2020-07-17

Applicant: TearClear Corp.

Inventor： Michael WILSON ,  Michael WILLIAMS ,  Deniz HAY ,  Michael MALANGA

IPC: A61J1/14 ,  A61K31/5377 ,  A61K31/4985 ,  B01D71/26

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.