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公开(公告)号:US12276599B2
公开(公告)日:2025-04-15
申请号:US18142365
申请日:2023-05-02
Inventor: David Francis Plusquellic , Jasper Rose Stroud
IPC: G01N21/31
Abstract: A temporal magnification spectrometer includes a dual-chirp comb source, a signal leg, a local oscillator leg, an optical detector, and a temporal magnification analyzer. The dual-chirp comb source produces optical carrier laser light. A signal comb having signal linearly chirped waveforms interacts with a sample to produce a transmitted signal comb. The local oscillator leg produces a local oscillator comb having local oscillator linearly chirped waveforms. The optical detector receives the transmitted signal and local oscillator combs and produces an RF domain signal. The analyzer receives and Fourier transforms the RF domain signal to produce an RF comb, which is sampled to produce sampled RF comb lines, which are normalized to produce temporally magnified sample frequency domain data. Intermediate sample temporal data are normalized to produce a steady-state sample spectral response.
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公开(公告)号:US12276548B2
公开(公告)日:2025-04-15
申请号:US18141647
申请日:2023-05-01
Inventor: Ian Robert Coddington , Nathan Reynolds Newbury , Jean-Daniel Deschenes , Fabrizio Raphael Giorgetta , Esther Baumann
Abstract: Embodiments of the present invention relate to apparatus and methods for dual comb spectroscopy with deterministic stepping and scanning of temporal pulse offset. In one embodiment, the present invention relates to a novel dual-comb spectroscopy including mode locked robust Er-combs and digital phase-locking electronics for step scanning between the two frequency combs and applicable to any phase-locked dual-comb system. The tight phase control of the DCS source allows for the control of temporal offset between the two comb pulses during measurements.
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公开(公告)号:US20250099570A1
公开(公告)日:2025-03-27
申请号:US18892905
申请日:2024-09-23
Applicant: University of Maryland, College Park , Government of the United States of America, as represented by the Secretary of Commerce
Inventor: Gilad Adi Ofek , Benjamin M. Janus , Thomas R. Fuerst , Thomas E. Cleveland, IV
IPC: A61K39/12 , A61P31/14 , C07K14/005 , C07K16/10 , C12N7/00 , G01N33/569 , G01N33/68
Abstract: The present disclosure relates generally to antibodies, such as antibodies and fragments thereof, that bind to the marburgvirus glycoprotein. Such antibodies have many applications including their use as antiviral drugs for treatment and prevention of diseases resulting from marburgvirus infection.
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公开(公告)号:US12209912B2
公开(公告)日:2025-01-28
申请号:US17747443
申请日:2022-05-18
Inventor: Nathan Andrew Tomlin , Christopher Shing-Yu Yung
IPC: G01J5/20 , G01J5/08 , G01J5/0818 , G02B6/42
Abstract: Embodiments of the present invention relate to an optical detector system capable of detecting in the infrared and terahertz regions of the electromagnetic spectrum with increased sensitivity and simplicity. It includes microbolometers in an array, a waveguide for receiving readout light input from an optical light source, waveguide splitters for splitting the waveguide to output waveguides such that each microbolometer in the array is optically coupled to an output waveguide. The output waveguide is coupled to an optical resonator of the microbolometer at a resonance frequency to generate a readout light output having a characteristic based on a change in a characteristic of the optical resonator. The system further includes a detector for receiving the readout light output from each of the output waveguides to convert the readout light output to an electrical signal.
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公开(公告)号:US20240403622A1
公开(公告)日:2024-12-05
申请号:US18203845
申请日:2023-05-31
Abstract: Embodiments of the present invention related to a neuromimetic circuit including a transmitter circuit to receive the threshold signal from a superconducting optoelectronic neuron and convert the small current pulse to a voltage pulse sufficient to produce light from a semiconductor diode. This light is the signal used to communicate between neurons in the network. The transmitter circuit in accordance with the present invention includes an amplifier chain that comprises two Josephson junctions, a superconducting thin-film current-gated current amplifier, and a superconducting thin-film current-gated voltage amplifier. The transmitter circuit in accordance with the present invention enable an amplification sequence that allows neuronal firing of about 20 MHz with power density sufficiently low to be cooled with standard 4He cryogenic systems operating at 4.2 K.
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公开(公告)号:US20240402007A1
公开(公告)日:2024-12-05
申请号:US17512279
申请日:2021-10-27
Inventor: Adam Nykoruk McCaughan , Boris Alexander Korzh , Varun Boehm Verma , Sae Woo Nam
Abstract: A thermally coupled imager includes a single photon detection pixel electrically isolated but in thermal communication with a thermal readout bus via a thermally conductive galvanic isolator, wherein the single photon detection pixel receives a single photon and produces thermal energy that is communicated to the thermal readout bus. A position and time of arrival of the single photon received by the single photon detection pixel is determined from voltage pulses produced by the thermal readout bus in response to receiving the thermal energy from the single photon detection pixel.
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公开(公告)号:US12158410B2
公开(公告)日:2024-12-03
申请号:US17106961
申请日:2020-11-30
Applicant: SOL INC. , Government of the United States of America, as Represented by the Secretary of Commerce
Inventor: Jong Muk Lee , Darwin R. Reyes-Hernandez , Brian J. Nablo
IPC: G01N15/1433 , G01N15/14 , G01N15/1434 , G01N33/50
Abstract: The present disclosure relates to a real-time quantification method of cell viability through a supravital dye uptake using a lens-free imaging system. The method includes a step of incubating a sample cell in a cell culture medium, steps of detecting light penetrating the cell culture medium and identifying a boundary region of the sample cell at a preset time interval based on the detected light, a step of staining the incubated sample cell with the supravital dye, a step of detecting intensity of light penetrating the cell culture medium at a preset time interval, a step of calculating absorbance of the sample cell included in the cell culture medium at a preset time interval based on the boundary region and the detected intensity of light and a step of analyzing a viability of the sample cell based on the calculated absorbance.
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公开(公告)号:US20240333394A1
公开(公告)日:2024-10-03
申请号:US18625927
申请日:2024-04-03
Inventor: Kevin O'Connell Douglass , Nikolai Nikolaevich Klimov , Ashutosh Rao
IPC: H04B10/556 , H04B10/079 , H04B10/50
CPC classification number: H04B10/5561 , H04B10/07955 , H04B10/504
Abstract: A high precision photonic readout for performing high precision photon sensing includes a laser source, photonic sensor, photonic sensor measurement module, laser and stabilization module. The photonic sensor measurement module receives the sensor light and produces a modulator control signal. The laser stabilization module receives the reference light and produces a phase lock signal that stabilizes the reference light frequency that controls the laser source to produce the reference light.
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公开(公告)号:US20240260484A1
公开(公告)日:2024-08-01
申请号:US18632077
申请日:2024-04-10
Applicant: PsiQuantum Corp. , Government of the United States of America, as Represented by the Secretary of Commerce
Inventor: Faraz Najafi , Qiaodan Jin Stone , Adam Nykoruk McDaughan
Abstract: An example electric circuit includes a superconductor component having a first terminal at a first end and a second terminal at a second end. The superconductor component includes a first portion coupled to the first terminal, a second portion coupled to the second terminal, and a third portion coupling the first portion and the second portion. The third portion has a curved shape such that the first portion of the superconductor component is proximate to, and thermally coupled to, the second portion of the superconductor component. The example electric circuit further includes a coupling component coupled to the third portion of the superconductor component, and a gate component configured to generate a resistive heat that exceeds a superconducting threshold temperature of the superconductor component, where the gate component is separated from the superconductor component by the coupling component.
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公开(公告)号:US20240249176A1
公开(公告)日:2024-07-25
申请号:US18560591
申请日:2022-05-12
Inventor: Lucas Tyler Brady , Alexey Vyacheslavovich Gorshkov , Christopher Lee Baldwin , Aniruddha Bapat , Yaroslav Kharkov , Przemyslaw Dariusz Bienias , Lucas Kocia
Abstract: A process for bang-anneal-bang quantum optimization includes: identifying base curve v(t); setting a total runtime of the process; creating an initial guess for parameters in an ansatz; creating an initial guess for parameters in an ansatz; evolving a quantum state from a ground state of B following Hamiltonian H(t)=u(t) B+(1−u(t)) C and, at termination of evolving the quantum state, measuring the resulting quantum state; updating the parameters for the ansatz based on the resulting quantum state; repetitively creating the ansatz for u(t), evolving the quantum state from the ground state of B following Hamiltonian H(t), and, at termination of evolving the quantum state, determining the resulting quantum state until the classical outer loop converges to a selected convergence limit; and returning the final form of u(t) to perform bang-anneal-bang quantum optimization.
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