公开(公告)号：US20220348615A1

公开(公告)日：2022-11-03

申请号：US17724712

申请日：2022-04-20

Applicant: Norwegian University of Science and Technology (NTNU) ,  UNIVERSITÄT ULM ,  NORWEGIAN UNIVERSITY OF LIFE SCIENCES ,  DANMARKS TEKNISKE UNIVERSITET ,  UNIVERSITÄT DES SAARLANDES

Inventor： Gerd Michael SEIBOLD ,  Christoph WITTMANN ,  Dzung DIEP ,  Nadav BAR ,  Christian U. REIDEL ,  Dominik WEIXLER ,  Oliver GOLDBECK

IPC: C07K14/34

Abstract: The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.

公开(公告)号：US20210325293A1

公开(公告)日：2021-10-21

申请号：US16479689

申请日：2018-01-26

Applicant: UNIVERSITÄT ULM

Inventor： Daniel GEIGER ,  Tobias NECKERNUSS ,  Othmar MARTI

IPC: G01N15/14 ,  G06T7/00 ,  G06T7/269 ,  G01N1/40

Abstract: Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.

公开(公告)号：US10384230B2

公开(公告)日：2019-08-20

申请号：US15537545

申请日：2015-12-14

Applicant: UNIVERSITÄT ULM

Inventor： Steffen Strehle ,  Daniel Markus Rosskopf ,  Andreas Magnus Probst

IPC: B05D1/28 ,  H05K3/12 ,  B81C1/00 ,  H05K1/03 ,  H05K1/09 ,  B82B3/00 ,  H05K3/10

Abstract: The invention relates to a method for producing a substrate structured by nanowires, characterized in that no lubricant and no lithographic resist mask is used in the method, and only by moving a donor substrate having nanowires relative to a substrate and by locally tribological properties on the surface of the substrate, a specified number of nanowires is deposited selectively at locally defined points of the substrate. The invention further relates to a substrate that can be produced using the method according to the invention, and which selectively contains a specified number of nanowires on a surface at locally defined points. The invention further relates to the use of the substrate according to the invention in microelectronics, microsystems technology, and/or micro-sensor systems.

公开(公告)号：US20240294905A1

公开(公告)日：2024-09-05

申请号：US17921922

申请日：2021-04-26

Applicant: Universität Ulm

Inventor： Tobias Böckers ,  Stefanie Pfänder ,  Nadine Stirmlinger

IPC: C12N15/113 ,  G01N33/53

CPC classification number: C12N15/113 ,  G01N33/53 ,  C12N2310/11 ,  G01N2800/52

Abstract: The present invention relates to an oligonucleotide specifically binding to a polynucleotide comprising the nucleic acid sequence of SEQ ID NO:1. The present invention also relates to said oligonucleotide for use in medicine and for use in treatment and/or prevention of Shank3 deficiency, preferably for use in treatment and/or prevention of Phelan-McDermid syndrome. The present invention also relates to expression constructs, host cells, and methods related thereto.

公开(公告)号：US20240241195A1

公开(公告)日：2024-07-18

申请号：US18582293

申请日：2024-02-20

Applicant: NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Martin PLENIO ,  Benedikt TRATZMILLER

IPC: G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC classification number: G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US11940510B2

公开(公告)日：2024-03-26

申请号：US17995232

申请日：2021-03-31

Applicant: NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

Inventor： Ilai Schwartz ,  Michael Keim ,  Martin Plenio ,  Benedikt Tratzmiller

IPC: G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC classification number: G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US11788950B2

公开(公告)日：2023-10-17

申请号：US16479689

申请日：2018-01-26

Applicant: UNIVERSITÄT ULM

Inventor： Daniel Geiger ,  Tobias Neckernuss ,  Othmar Marti

IPC: G01N15/14 ,  G06T7/00 ,  G06T7/269 ,  G01N1/40 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1475 ,  G01N1/40 ,  G01N15/1431 ,  G01N15/1436 ,  G06T7/0016 ,  G06T7/269 ,  G01N2015/0019 ,  G01N2015/1081 ,  G01N2015/1495 ,  G06T2207/30024

Abstract: Disclosed is a method for analysing cells, in which cells are separated and the individual cells pass via a measurement region of a unit for spatially resolved radiation intensity measurement, wherein, for at least one of the separated cells, when passing via the measurement region, a time sequence of spatial intensity patterns of an electromagnetic radiation emitted from and/or influenced by the cell is created, the optical flow of a respective two of the spatial intensity patterns is calculated for at least one portion of the sequence of intensity patterns using a computer unit, and an evaluation of the calculated optical flows occurs. Also disclosed is a device for analysing cells, comprising a device for separating cells, a unit for spatially resolved radiation intensity measurement, and a computer unit for calculating the optical flow of a respective two of the created intensity patterns, and for evaluating the calculated optical flows.

公开(公告)号：US11052082B2

公开(公告)日：2021-07-06

申请号：US16000467

申请日：2018-06-05

Applicant: UNIVERSITÄT ULM

Inventor： Claudia Friesen ,  Erich Miltner

IPC: A61K31/137 ,  A61K31/485 ,  A61K31/704 ,  A61K45/06 ,  A61K31/4468 ,  A61K31/7048 ,  A61K31/7076 ,  A61K33/24 ,  G01N33/50 ,  A61K31/445

Abstract: The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.

公开(公告)号：US10408725B2

公开(公告)日：2019-09-10

申请号：US13631936

申请日：2012-09-29

Applicant: Lawrence Livermore National Security, LLC ,  Universität Ulm

Inventor： Jerry Chance Carter ,  Michael P. Chrisp ,  Anastacia M. Manuel ,  Boris Mizaikoff ,  Andreas Wilk ,  Seong-Soo Kim

IPC: G02B6/032 ,  G01N9/00 ,  G01N9/24 ,  G01N21/47 ,  G01N21/05 ,  G01N21/35 ,  G02B6/10 ,  G01N21/03 ,  G01N21/3504 ,  G01N21/3577

Abstract: Methods and apparatuses are provided that greatly expand the utility of conventional hollow waveguide-based sensors via either straight, substrate-integrated channels or via meandering (e.g., circuitous, curved or folded optical paths) waveguide sensor designs. Full- or hybrid-integration of the meandering hollow waveguide with light source, detector, and light-guiding optics facilitates compact yet high-performance gas/vapor and/or liquid sensors of the substrate-integrated hollow waveguide sensor.

公开(公告)号：US20180280380A1

公开(公告)日：2018-10-04

申请号：US16000467

申请日：2018-06-05

Applicant: UNIVERSITÄT ULM

Inventor： Claudia Friesen ,  Erich Miltner

IPC: A61K31/485 ,  G01N33/50 ,  A61K45/06 ,  A61K31/445 ,  A61K31/137 ,  A61K31/4468 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7076 ,  A61K33/24

Abstract: The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.