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    MASSAGE TOOL
    1.
    发明申请
    MASSAGE TOOL 审中-公开
    按摩工具

    公开(公告)号：US20150272774A1

    公开(公告)日：2015-10-01

    申请号：US14477181

    申请日：2014-09-04

    Applicant: Wen-Hwa LEE

    Inventor： Wen-Hwa LEE

    IPC: A61F7/00 ,  A61H99/00

    CPC classification number: A61F7/00 ,  A61F2007/0062 ,  A61F2007/0094 ,  A61H15/0092 ,  A61H23/0263 ,  A61H39/04 ,  A61H39/06 ,  A61H2015/0014 ,  A61H2015/0064 ,  A61H2015/0071 ,  A61H2201/0107 ,  A61H2201/0207 ,  A61H2201/0228 ,  A61H2201/0257 ,  A61H2201/102 ,  A61H2201/501 ,  A61H2201/5015 ,  A61H2201/5097

    Abstract: A massage tool includes a main body; and an active member coupled to the main body. The active member includes an active material capable of being heated for transferring heat to the main body so as to activate or reactivate the massage tool. If necessary, more than one active material may be included in the active member. Heat can be transferred from the active material to the main body by way of conduction of the active material or convection of an active vapor released from the active material. The active vapor, for example, can be steam for providing heat and/or vaporized essential oil for aromatic treatment. The active material, for example, can be heated by an external heating source or an internal heating source.

    Abstract translation: 按摩工具包括主体; 以及联接到所述主体的活动构件。 活性构件包括能够被加热以将热量传递到主体以活化或重新激活按摩工具的活性材料。 如果需要，活性物质中可以包含多于一种活性物质。 可以通过活性材料的传导或从活性材料释放的活性蒸气的对流将热量从活性材料转移到主体。 例如，活性蒸气可以是用于提供用于芳香处理的热和/或汽化精油的蒸汽。 活性物质例如可以通过外部加热源或内部加热源加热。

    Human esterase D, its uses and a process of purification
    7.
    发明授权
    Human esterase D, its uses and a process of purification 失效
    人类酯酶D，其用途和纯化方法

    公开(公告)号：US5011773A

    公开(公告)日：1991-04-30

    申请号：US91547

    申请日：1987-08-31

    Applicant: Wen-Hwa Lee ,  Eva Y. P. Lee

    Inventor： Wen-Hwa Lee ,  Eva Y. P. Lee

    IPC: A61K38/00 ,  C12N9/16 ,  C12P21/04 ,  C12Q1/68

    CPC classification number: C12Q1/6876 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q1/6886 ,  A61K38/00 ,  C12N2799/026 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: This invention relates in general to a human esterases and in particular to the human esterase D enzyme and identification of its amino acid sequence, to a human esterase D cDNA and identification of its nucleotide sequence, to localization of the human esterase D gene and identification of its sequence, to specific human esterase D antibodies and to a method of purifying esterase D. The present invention also relates to using the cloned human esterase D cDNA as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region. The invention further relates to an esterase D cDNA probe for cloning the retinoblastoma gene and to the use of the cloned human esterase cDNA as a prognostic tool for determination of genetic predisposition to retinoblastoma or Wilson's disease and for population screening. Finally, this invention relates to the use of the cloned human esterase D for exploration of the large family of human esterases.

    Abstract translation: 本发明一般涉及人酯酶，特别涉及人酯酶D酶及其氨基酸序列的鉴定，人类酯酶D cDNA及其核苷酸序列的鉴定，以及人类酯酶D基因的定位和鉴定 其序列，特异性人酯酶D抗体和纯化酯酶D的方法。本发明还涉及使用克隆的人类酯酶D cDNA作为视网膜母细胞瘤，威尔逊氏病和其他遗传性或获得性疾病的遗传标记和诊断工具 由位于13染色体13q14区域的基因控制。 本发明还涉及用于克隆视网膜母细胞瘤基因的酯酶D cDNA探针以及克隆的人类酯酶cDNA作为测定视网膜母细胞瘤或威尔逊氏病遗传易感性以及群体筛选的预后工具的用途。 最后，本发明涉及克隆的人类酯酶D用于探索大量人类酯酶的研究。

    Compositions and Methods for Disruption of BRCA2-Rad51 Interaction
    10.
    发明申请
    Compositions and Methods for Disruption of BRCA2-Rad51 Interaction 有权
    BRCA2-Rad51相互作用中断的组成和方法

    公开(公告)号：US20090221634A1

    公开(公告)日：2009-09-03

    申请号：US11577445

    申请日：2005-10-19

    Applicant: Wen-Hwa Lee ,  Phang-Lang Chen ,  Jiewen Zhu

    Inventor： Wen-Hwa Lee ,  Phang-Lang Chen ,  Jiewen Zhu

    IPC: A61K31/4725 ,  C12N5/06 ,  C12N13/00

    CPC classification number: A61K31/4725

    Abstract: Contemplated compounds disrupt interaction between BRCA2 and RAD51, likely by binding to RAD51. Based on the crucial role of the BRCA2-RAD51 complex formation in DNA repair and the role of RAD51 in the control of entry into S-phase from G1, numerous compositions and methods are presented. Among other advantageous uses, contemplated compounds may be employed as protective agents for non-neoplastic cells in chemotherapy before exposure of the cells to a chemotherapeutic drug, and/or as DNA-damage sensitizer for neoplastic cells.

    Abstract translation: 考虑的化合物可能通过结合RAD51扰乱BRCA2和RAD51之间的相互作用。 基于BRCA2-RAD51复合物形成在DNA修复中的关键作用和RAD51在控制从G1进入S期的作用，提出了许多组合物和方法。 除了其它有利的用途之外，预期的化合物可以在细胞暴露于化学治疗药物之前和/或作为肿瘤细胞的DNA损伤敏化剂中用作化疗中的非肿瘤细胞的保护剂。

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