公开(公告)号：US3725385A

公开(公告)日：1973-04-03

申请号：US3725385D

申请日：1970-11-02

Applicant: ABBOTT LAB

Inventor： FREIBERG L

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: The 3-dimethyl amino substituent of the desosamine and mycaminose moieties of macrolide antibiotics are mono- and didemethylated by reaction with halogen, preferably iodine, in the presence of base at a controlled pH. The resulting compounds have antibiotic activity, and furthermore are useful as intermediates for alkylation and the like.

Abstract translation: 通过在碱的存在下，在受控的pH下，通过与卤素，优选碘反应，将大环内酯类抗生素的脱氨基胺和霉酚酸部分的3-二甲基氨基取代基单取代和未甲基化。 所得化合物具有抗菌活性，此外可用作烷基化等的中间体。