公开(公告)号：US3748044A

公开(公告)日：1973-07-24

申请号：US3748044D

申请日：1971-04-12

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: G01J1/16 ,  G01N1/00 ,  G01N21/27 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01J3/46 ,  G01N1/10 ,  G01N33/16

CPC classification number: G01N35/025 ,  G01J1/16 ,  G01N21/27 ,  G01N21/272 ,  G01N2035/00396 ,  G01N2035/0448

Abstract: The disclosure describes an improved system for evaluating rates of reactions and end point determinations that take place within a plurality of individaul secimens. The system includes a cuvette for holding each of the specimens in an individual compartment. Analyzing apparatus is used to generate and sequentially transmit a beam of radiant energy through each of the specimens. The analysis apparatus also produces an analysis signal having a value proportional to a property of a particular specimen each time the beam passes through that specimen. Cycling apparatus causes the beam to sequentially and separately pass through each of the specimens during multiple cycles of operation. During the first cycle of operation, a first set of analysis signals having a first set of values corresponding to the specimens is created. Likewise, during a second cycle of operation, a second set of analysis signals having a second set of values corresponding to the specimens is created. In order to determine the rate at which the reactions take place within each of the specimens, a memory is used to store at least the first set of values. Then, during the second cycle of operation, a processing circuit compares the values of the first and second sets of values which correspond to the same specimen. In this way, the rate of reaction of each specimen is automatically determined. By a similar technique, values can be created and compared in seconds in order to determine rates of reactions that proceed rapidly. In order to analyze end joint determinations, one of the specimens comprises a known concentration of a substance, and other specimens contain unknown concentrations of the substance. The value corresponding to the known concentration is stored in the memory, and other values correspndingly to the unknown concentration are compared with the value stored in the memory. Improved components of the system such as a cuvette, a specimen dispenser, and an analyzing apparatus are also disclosed in the specification. The analyzing apparatus preferably comprises apparatus for instantaneously determining the concentration of a predetermined substance that absorbs radiant energy within a predetermined band of wavelengths in the presence of other interfering substances that also absorb radiant energy in the region of the predetermined band. The determination is made by generating multiple wavelengths of radiant energy. The radiant energy is then sequentially transmitted in a single path through the substances, and the transmission is periodically interrupted by means which prevent the transmission of any radiation. The intensities of the radiant energy transmitted through the substances at the various wavelengths are then compared by electronic apparatus.

Abstract translation: 本公开描述了一种改进的系统，用于评估在多个个体中发生的反应速率和终点测定。 该系统包括用于将每个样本保持在单独隔室中的比色皿。 分析装置用于通过每个样本产生并依次传送辐射能束。 分析装置还产生一个分析信号，该分析信号在每次束通过该样本时具有与特定样品的性质成比例的值。 循环装置在多个操作周期期间使光束顺序并分别通过每个样本。 在第一操作周期期间，产生具有与样本对应的第一组值的第一组分析信号。 类似地，在第二操作周期期间，产生具有对应于样本的第二组值的第二组分析信号。

公开(公告)号：US3811780A

公开(公告)日：1974-05-21

申请号：US35706373

申请日：1973-05-03

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: G01N21/03 ,  G01N35/00 ,  G01N35/04 ,  G01J3/46 ,  G01N1/10

CPC classification number: G01N21/03 ,  G01N2035/00396 ,  G01N2035/0448

Abstract: Improved components, such as a cuvette, are disclosed in the specification.

Abstract translation: 在说明书中公开了诸如比色皿的改进的部件。

公开(公告)号：US3833304A

公开(公告)日：1974-09-03

申请号：US35706473

申请日：1973-05-03

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: G01N21/31 ,  G01N33/483 ,  G01N35/00 ,  G01N35/04 ,  G01J3/48

CPC classification number: G01N21/314 ,  G01N2021/3148 ,  G01N2035/00396 ,  G01N2035/0448

Abstract: The disclosure describes apparatus for instantaneously determining the concentration of a predetermined substance that absorbs radiant energy within a predetermined band of wavelengths in the presence of other interfering substances that also absorb radiant energy in the region of the predetermined band. The determination is made by generating multiple wavelengths of radiant energy. The radiant energy is then sequentially transmitted in a single path through the substances, and the transmission is periodically interrupted by means which prevent the transmission of any radiation. The intensities of the radiant energy transmitted through the substances at the various wavelengths are then compared by electronic apparatus.

Abstract translation: 本公开描述了用于在存在也吸收预定带区域中的辐射能的其它干扰物质的情况下，瞬时地确定吸收预定波段内的辐射能的预定物质的浓度的装置。 通过产生多个波长的辐射能来进行确定。 然后，辐射能量通过物质在单个路径中顺序传输，并且通过阻止任何辐射的传输的装置周期性地中断传输。 然后通过电子设备比较透过各种波长物质的辐射能的强度。

公开(公告)号：US3831618A

公开(公告)日：1974-08-27

申请号：US31775372

申请日：1972-12-22

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: B01L3/02 ,  G01F11/02 ,  G01F11/06 ,  G01N1/00 ,  G01N1/38 ,  G01N35/10 ,  F16K19/00

CPC classification number: G01N35/1016 ,  B01L3/0227 ,  G01F11/029 ,  G01N1/38 ,  Y10T137/2931

Abstract: There is disclosed a first capillary conduit having a minute aperture therein, the aperture dividing the first conduit into a separate and a common section, there being a first fluid conducting path formed through the separate and common sections. A second capillary conduit has one end thereof intersecting the first conduit and mating with the minute aperture to form a second fluid conducting path through the second conduit and the common section of the first conduit. The minute aperture forms a first precise interface between the first fluid path and the second conduit. The capillary cross-section of the first conduit separate section adjacent the minute aperture forms a second precise interface between the second fluid conducting path and the separate section, whereby fluid can traverse the first fluid path substantially free from contamination from fluids adjacent the first precise interface and fluids can traverse the second path substantially free from contamination from fluid adjacent the second precise interface.

Abstract translation: 公开了一种在其中具有微小孔的第一毛细导管，该孔将第一导管分成一个单独的和共同的部分，其中形成有通过分离的和共同的部分形成的第一流体传导路径。 第二毛细导管的一端与第一导管相交，并与微孔相配合以形成通过第二导管和第一导管的公共部分的第二流体传导路径。 微小孔在第一流体路径和第二管道之间形成第一精确界面。 邻近微小孔的第一导管分离部分的毛细管横截面在第二流体传导路径和分离区段之间形成第二精确界面，由此流体可以穿过基本上不受来自邻近第一精确界面的流体污染的第一流体路径 并且流体可以穿过基本上不受来自与第二精确界面相邻的流体污染的第二路径。

公开(公告)号：US3817425A

公开(公告)日：1974-06-18

申请号：US35706573

申请日：1973-05-03

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: G01N1/38 ,  G01N33/483 ,  G01N35/00 ,  G01N35/04 ,  G01F11/16

CPC classification number: G01N1/38 ,  G01N2035/00396 ,  G01N2035/0448

Abstract: The disclosure describes a specimen dispenser in which first and second syringes are used to dispense a sample liquid and a reagent liquid. The inlet orifice of the second syringe is connected to a second end opening of the first syringe through a three-way valve so that the first syringe is purged by reagent liquid each time a dispensing operation is completed.

Abstract translation: 本公开描述了一种样本分配器，其中第一和第二注射器用于分配样品液体和试剂液体。 第二注射器的入口孔通过三通阀连接到第一注射器的第二端开口，使得每次完成分注操作时，第一注射器被试剂液体清除。