公开(公告)号：US3663549A

公开(公告)日：1972-05-16

申请号：US3663549D

申请日：1969-10-06

Applicant: ABBOTT LAB

Inventor： MICHAELS RAYMOND JOHN JR ,  ZAUGG HAROLD ELMER

IPC: C07D219/06 ,  C07D295/084 ,  C07D311/90 ,  C07D51/70

CPC classification number: C07D295/092 ,  C07C2603/18 ,  C07D219/06 ,  C07D311/90

Abstract: A NOVEL SERIES OF DIARYL HYDROXYETHYL TERTINARY AMINES REPRESENTED BY GENERAL FORMULAE I AND II

(I) HO-C(-AR)2-CH2-N(-R)2

(II) HO-C
WHEREIN AR REPRESENTS AN ARYL RADICAL, NR2 SIGNIFIES A TERTIARY AMINE IN FORMULA I, AND X REPRESENTS O, S, -NCH3, -CH2-CH2-, -CH=CH- AND A DIRECT SINGLE BOND, NR2 IS A PREVIOUSLY DESRIBED IN FORMULA II. THE NOVEL METHOD FOR MAKING THESE COMPOUNDS COMPRISES FIRST REACTING THE APPROPRIATE DIARYL KETONE WITH AN ALKALI METAL REDUCING AGENT, FOLLOWED BY ALKYLATION WITH A SODIUM FORMALDEHYDE BISULPHITE DERIVATIVE OF A SECONDARY AMINE TO YELD THE FINAL PRODUCT. THE COMPOUNDS MADE ACCORDING TO THIS NOVEL PROCESS ARE USEFUL AS ANTISPASMODIC AGENTS.