公开(公告)号：US10702496B2

公开(公告)日：2020-07-07

申请号：US15962545

申请日：2018-04-25

Applicant: ABBOTT LABORATORIES

Inventor： Chron-si Lai ,  Matthew Kuchan

IPC: A61K31/202 ,  A61K31/355 ,  A61K47/22 ,  A61K9/00 ,  A61P3/02 ,  A23L33/00 ,  A23L33/12 ,  A23L33/15

Abstract: Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system development in an individual. The nutritional compositions include a combination of RRR-alpha tocopherol acetate, non-RRR-alpha-tocopherol stereoisomers, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited.

公开(公告)号：US20160022710A1

公开(公告)日：2016-01-28

申请号：US14774745

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Tama Bloch ,  Christina Sherry ,  Maria Ramirez Gonzalez ,  Matthew Kuchan ,  Gary Katz ,  Elena Oliveros Delgado ,  Angela Santos

IPC: A61K31/685 ,  A61K31/202 ,  A61K31/047 ,  A23L1/29 ,  A61K31/015 ,  A61K31/045 ,  A61K9/48 ,  A61K31/355 ,  A61K31/593

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/48 ,  A61K9/4808 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/065 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K2300/00

Abstract: Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.

Abstract translation: 公开了孕妇和哺乳期妇女的产前和哺乳期补品，其中包括RRR-α-生育酚，二十二碳六烯酸（DHA），反式叶黄素，磷脂以及除RRR-α-生育酚之外的至少一种核受体活化配体的组合， 生育酚，DHA和反式叶黄素。 补充剂可以增强胎儿或母乳喂养新生儿的中枢神经系统发育。

公开(公告)号：US09993457B2

公开(公告)日：2018-06-12

申请号：US15529305

申请日：2015-11-25

Applicant: ABBOTT LABORATORIES

Inventor： Matthew Kuchan ,  Chron-Si Lai ,  Jacqueline Boff

IPC: A61K31/335 ,  A61K31/01 ,  A61K31/07 ,  A61K31/59 ,  A61K31/12 ,  A61K31/20 ,  A61K31/355 ,  A23L33/155 ,  A23L33/12 ,  A23L33/15 ,  A23L33/00 ,  A61K31/015 ,  A61K31/047

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/065 ,  A61K31/122 ,  A61K2300/00

Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

公开(公告)号：US20180085343A1

公开(公告)日：2018-03-29

申请号：US15829412

申请日：2017-12-01

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/375 ,  A23L33/15 ,  A61K31/202 ,  A61K31/05 ,  A23L33/00

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US09980939B2

公开(公告)日：2018-05-29

申请号：US14771719

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan

IPC: A61K31/355 ,  A61K31/202 ,  A61K47/22 ,  A61K9/00 ,  A23L33/12 ,  A23L33/15 ,  A23L33/00

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/202 ,  A61K47/22 ,  A23V2200/322 ,  A23V2250/1862 ,  A23V2250/1868 ,  A23V2250/211 ,  A23V2250/54 ,  A23V2250/708 ,  A23V2250/712

Abstract: Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited. Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.

公开(公告)号：US20160022628A1

公开(公告)日：2016-01-28

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/375 ,  A23L1/302 ,  A61K31/202 ,  A23L1/29 ,  A23L1/30

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

Abstract translation: 本发明涉及通过施用天然生育酚的混合物来改善婴儿的CNS成熟的方法，其中所述组合物含有类似于在人母乳中发现的最适生育酚谱，并且可以包括从早期到过渡到 成熟的人类母乳。 为了易于施用和最大化效力，天然生育酚的优化混合物通常以具有有限水平的非RRRα-生育酚的口服剂型递送，以使RRRα-生育酚对刺激出生后CNS发育的功效最大化。

公开(公告)号：US10328049B2

公开(公告)日：2019-06-25

申请号：US15829412

申请日：2017-12-01

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/375 ,  A23L33/15 ,  A61K31/202 ,  A61K31/05 ,  A23L33/00

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US10245250B2

公开(公告)日：2019-04-02

申请号：US15977390

申请日：2018-05-11

Applicant: ABBOTT LABORATORIES

Inventor： Matthew Kuchan ,  Chron-Si Lai ,  Jacqueline Boff

IPC: A61K31/365 ,  A61K31/59 ,  A61K31/12 ,  A61K31/20 ,  A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/00 ,  A61K31/015 ,  A61K31/047 ,  A61K31/01 ,  A61K31/065 ,  A61K31/122

Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

公开(公告)号：US09844532B2

公开(公告)日：2017-12-19

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/202 ,  A61K31/05 ,  A61K31/375 ,  A23L33/00 ,  A23L33/12 ,  A23L33/15

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US20160008318A1

公开(公告)日：2016-01-14

申请号：US14771719

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan

IPC: A61K31/355 ,  A61K47/22 ,  A23L1/302 ,  A23L1/29 ,  A23L1/30 ,  A61K31/202 ,  A61K9/00

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/202 ,  A61K47/22 ,  A23V2200/322 ,  A23V2250/1862 ,  A23V2250/1868 ,  A23V2250/211 ,  A23V2250/54 ,  A23V2250/708 ,  A23V2250/712

Abstract: Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.

Abstract translation: 公开了营养组合物，特别是婴儿配方，其包括RRR-α生育酚，脂肪和蛋白质的组合。 营养组合物中非RRRα-生育酚立体异构体的量是有限的。还公开了使用组合物改善个体中认知，脑和/或中枢神经系统发育的方法。