公开(公告)号：US20160022710A1

公开(公告)日：2016-01-28

申请号：US14774745

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Tama Bloch ,  Christina Sherry ,  Maria Ramirez Gonzalez ,  Matthew Kuchan ,  Gary Katz ,  Elena Oliveros Delgado ,  Angela Santos

IPC: A61K31/685 ,  A61K31/202 ,  A61K31/047 ,  A23L1/29 ,  A61K31/015 ,  A61K31/045 ,  A61K9/48 ,  A61K31/355 ,  A61K31/593

CPC classification number: A61K31/685 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/48 ,  A61K9/4808 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/065 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K2300/00

Abstract: Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.

Abstract translation: 公开了孕妇和哺乳期妇女的产前和哺乳期补品，其中包括RRR-α-生育酚，二十二碳六烯酸（DHA），反式叶黄素，磷脂以及除RRR-α-生育酚之外的至少一种核受体活化配体的组合， 生育酚，DHA和反式叶黄素。 补充剂可以增强胎儿或母乳喂养新生儿的中枢神经系统发育。

公开(公告)号：US11129404B2

公开(公告)日：2021-09-28

申请号：US16066585

申请日：2016-12-27

Applicant: ABBOTT LABORATORIES

Inventor： Tapas Das ,  Mustafa Vurma ,  Chron-Si Lai ,  Paul Johns

IPC: A23L33/00 ,  A61K38/01 ,  A23L33/12 ,  A23L33/19 ,  A23L33/18 ,  A23L33/115 ,  A61K45/06 ,  A23L29/00 ,  A61P25/28 ,  A23L33/125 ,  A61K31/575 ,  A61K31/685

Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

公开(公告)号：US20160029681A1

公开(公告)日：2016-02-04

申请号：US14774302

申请日：2014-03-12

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Randal Buddington ,  John Lasekan

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A23L33/40 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00

Abstract: A method of enhancing the bioavailability of a lipid-soluble nutrient, such as DHA, arachidonic acid, tocopherol, and carotenoids, in a newborn or preterm infant is disclosed. In this method, the lipid-soluble nutrient is administered in a nutritional product (such as an infant formula) to a preterm or newborn infant. The nutritional product comprises (a) an effective amount of the lipid-soluble nutrient; and (b) a fatty component comprising a combination of: (i) at least 6 g/l predigested fat, wherein the predigested fat includes at least one of: monoglycerides, free fatty acids, or a combination of monoglycerides and free fatty acids, and (ii) at least 1.44 g/l phospholipid. A method of enhancing cognition in newborn or preterm infants utilizing the nutritional product is also disclosed.

Abstract translation: 公开了一种在新生儿或早产儿中增强脂溶性营养物质如DHA，花生四烯酸，生育酚和类胡萝卜素的生物利用度的方法。 在该方法中，将脂溶性营养物在营养产品（例如婴儿配方食品）中施用于早产或新生儿。 营养产品包括（a）有效量的脂溶性营养物质; 和（b）包含以下组合的脂肪组分：（i）至少6g / l预消化的脂肪，其中所述预消化的脂肪包括以下中的至少一种：单酸甘油酯，游离脂肪酸或单酸甘油酯和游离脂肪酸的组合， 和（ii）至少1.44g / l磷脂。 还公开了利用营养产品增强新生儿或早产儿认知的方法。

公开(公告)号：US09980939B2

公开(公告)日：2018-05-29

申请号：US14771719

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan

IPC: A61K31/355 ,  A61K31/202 ,  A61K47/22 ,  A61K9/00 ,  A23L33/12 ,  A23L33/15 ,  A23L33/00

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/202 ,  A61K47/22 ,  A23V2200/322 ,  A23V2250/1862 ,  A23V2250/1868 ,  A23V2250/211 ,  A23V2250/54 ,  A23V2250/708 ,  A23V2250/712

Abstract: Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited. Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.

公开(公告)号：US20160022628A1

公开(公告)日：2016-01-28

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/375 ,  A23L1/302 ,  A61K31/202 ,  A23L1/29 ,  A23L1/30

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

Abstract translation: 本发明涉及通过施用天然生育酚的混合物来改善婴儿的CNS成熟的方法，其中所述组合物含有类似于在人母乳中发现的最适生育酚谱，并且可以包括从早期到过渡到 成熟的人类母乳。 为了易于施用和最大化效力，天然生育酚的优化混合物通常以具有有限水平的非RRRα-生育酚的口服剂型递送，以使RRRα-生育酚对刺激出生后CNS发育的功效最大化。

公开(公告)号：US20160021919A1

公开(公告)日：2016-01-28

申请号：US14774592

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Randal Buddington

IPC: A23L1/29 ,  A23L1/30

CPC classification number: A23L33/40 ,  A23J7/00 ,  A23L33/12 ,  A23L33/13 ,  A23V2002/00

Abstract: A method of enhancing maturation of a lung, gut, or both in an infant. The method includes the step of administering to the infant a nutritional composition including from about 3 weight % phospholipids to about 20 weight % phospholipids, based on total fat of the nutritional composition.

Abstract translation: 一种在婴儿中增强肺，肠或两者成熟的方法。 该方法包括基于营养组合物的总脂肪向婴儿施用包含约3重量％磷脂至约20重量％磷脂的营养组合物的步骤。

公开(公告)号：US10328049B2

公开(公告)日：2019-06-25

申请号：US15829412

申请日：2017-12-01

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A23L33/12 ,  A61K31/375 ,  A23L33/15 ,  A61K31/202 ,  A61K31/05 ,  A23L33/00

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US10245250B2

公开(公告)日：2019-04-02

申请号：US15977390

申请日：2018-05-11

Applicant: ABBOTT LABORATORIES

Inventor： Matthew Kuchan ,  Chron-Si Lai ,  Jacqueline Boff

IPC: A61K31/365 ,  A61K31/59 ,  A61K31/12 ,  A61K31/20 ,  A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/00 ,  A61K31/015 ,  A61K31/047 ,  A61K31/01 ,  A61K31/065 ,  A61K31/122

Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

公开(公告)号：US09844532B2

公开(公告)日：2017-12-19

申请号：US14774889

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Matthew Kuchan ,  Gary Katz

IPC: A61K31/355 ,  A61K31/202 ,  A61K31/05 ,  A61K31/375 ,  A23L33/00 ,  A23L33/12 ,  A23L33/15

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/322 ,  A23V2250/712 ,  A61K31/05 ,  A61K31/202 ,  A61K31/375

Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

公开(公告)号：US09446005B2

公开(公告)日：2016-09-20

申请号：US14274133

申请日：2014-05-09

Applicant: ABBOTT LABORATORIES

Inventor： Chron-Si Lai ,  Keith A. Garleb ,  John B. Lasekan ,  Steven R. Davis ,  Christopher T. Cordle ,  Russell J. Merritt

IPC: A61K31/20 ,  A23D7/00 ,  A61K31/05 ,  A61K9/00 ,  A23L1/29 ,  A23L1/30

CPC classification number: A61K31/05 ,  A23K20/158 ,  A23K50/30 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/00 ,  A61K31/20

Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Abstract translation: 公开了营养配方，其包括可以对早产儿，婴儿，幼儿和儿童施用的预消化脂肪，用于改善营养物质的耐受性，消化和吸收以及降低坏死性小肠结肠炎，绞痛和短肠综合征的发生率。 预先消化的脂肪包括含脂肪酸的单甘油酯和/或脂肪酸组分。