公开(公告)号：US20170182001A1

公开(公告)日：2017-06-29

申请号：US15316700

申请日：2015-06-05

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Kuo-Hsiung LEE ,  Kyoko NAKAGAWA-GOTO ,  Jia-Hua FENG ,  Jo-Yu CHEN ,  Wai-Leng LEE ,  Yu-Ting CHENG ,  Jing-Ying HUANG

IPC: A61K31/365 ,  A61K31/655 ,  C07D493/18 ,  A61K31/337 ,  A61K31/437 ,  A61K31/198 ,  A61K45/06

CPC classification number: A61K31/365 ,  A61K31/198 ,  A61K31/337 ,  A61K31/437 ,  A61K31/655 ,  A61K45/06 ,  C07D493/18 ,  A61K2300/00

Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

公开(公告)号：US20190060388A1

公开(公告)日：2019-02-28

申请号：US16172428

申请日：2018-10-26

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Jia-Hua FENG ,  Maria Karmella APAYA

IPC: A61K36/88 ,  A61K31/25 ,  A61K36/28 ,  A61K8/9794

CPC classification number: A61K36/88 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/25 ,  A61K36/28 ,  A61K2236/33 ,  A61P1/16 ,  A61P31/04 ,  A61Q19/02 ,  A61K2300/00

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of :Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

公开(公告)号：US20140356301A1

公开(公告)日：2014-12-04

申请号：US14295173

申请日：2014-06-03

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Jia-Hua FENG ,  Maria Karmella APAYA

IPC: A61K31/7032 ,  A61K36/88 ,  A23L1/30 ,  A61Q19/02 ,  A61K8/60 ,  A61K36/28 ,  A61K8/97

CPC classification number: A61K31/7032 ,  A23L33/105 ,  A61K8/602 ,  A61K8/97 ,  A61K36/28 ,  A61K36/88 ,  A61K2236/00 ,  A61Q19/02

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of: Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

Abstract translation: 本发明涉及通过提取选自以下的植物样品制备的富含半乳糖脂的植物提取物：Gynura divaricata subsp。 菊科（菊科）（GD），小麦（Murdannia bracteata）（C.B.Clarke）J.K.Morton ex D.Y.Hong（Commelinaceae）（MB）和Crassocephalum rabens S.Moore（菊科）（CR）与一系列溶剂。 还提供了用于保护或治疗急性暴发性肝炎，用于保护或治疗败血症或其相关指征的药物，营养或保健组合物和用于皮肤美白的组合物。 这些组合物都包含有效量的富含脂肪体的植物提取物或其纯化的化合物作为生物活性成分。