公开(公告)号：US20240009259A1

公开(公告)日：2024-01-11

申请号：US18253662

申请日：2021-11-19

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Yu-Chuan LIANG ,  Yu-Hsin CHEN ,  Chuan-Ju LIN ,  Meng-Ting CHANG ,  Chung-Chih YANG

IPC: A61K36/28 ,  A61K31/7028 ,  A61P21/00 ,  A61P25/24

CPC classification number: A61K36/28 ,  A61K31/7028 ,  A61P21/00 ,  A61P25/24

Abstract: The present disclosure provides a method for preventing and/or treating fatigue and/or depression in a subject in need of such prevention and/or treatment, comprising administering to said subject an effective amount of Crassocephalum rabens plant or extract and optionally a pharmaceutically acceptable carrier or excipient. The present disclosure also provides a method for increasing skeletal muscle lactate dehydrogenase and/or malate dehydrogenase.

公开(公告)号：US20240196931A1

公开(公告)日：2024-06-20

申请号：US18286943

申请日：2022-04-14

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Yu-Chuan LIANG ,  Wen-Yuh LIN ,  Chin-Ting CHANG ,  Meng-Ting CHANG ,  Yu-Hsin CHEN

IPC: A23K10/30 ,  A23K50/30 ,  A61K36/28 ,  A61P31/14

CPC classification number: A23K10/30 ,  A23K50/30 ,  A61K36/28 ,  A61P31/14

Abstract: Provided is an animal feed composition including a plant-based feed additive. Also provided is a method for promoting overall health condition of an animal, including increase of feed efficiency and decrease of feed converting rate, increase of probiotics and decrease of pathogens in gut microbiota of pigs, anti-inflammation, affecting primary metabolism, promoting growth and survival rate, and preventing or treating diseases caused by pathogenic bacteria, porcine reproductive and respiratory syndrome virus (PRRSV).

公开(公告)号：US20190060388A1

公开(公告)日：2019-02-28

申请号：US16172428

申请日：2018-10-26

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Jia-Hua FENG ,  Maria Karmella APAYA

IPC: A61K36/88 ,  A61K31/25 ,  A61K36/28 ,  A61K8/9794

CPC classification number: A61K36/88 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/25 ,  A61K36/28 ,  A61K2236/33 ,  A61P1/16 ,  A61P31/04 ,  A61Q19/02 ,  A61K2300/00

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of :Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

公开(公告)号：US20140356301A1

公开(公告)日：2014-12-04

申请号：US14295173

申请日：2014-06-03

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Jia-Hua FENG ,  Maria Karmella APAYA

IPC: A61K31/7032 ,  A61K36/88 ,  A23L1/30 ,  A61Q19/02 ,  A61K8/60 ,  A61K36/28 ,  A61K8/97

CPC classification number: A61K31/7032 ,  A23L33/105 ,  A61K8/602 ,  A61K8/97 ,  A61K36/28 ,  A61K36/88 ,  A61K2236/00 ,  A61Q19/02

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of: Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

Abstract translation: 本发明涉及通过提取选自以下的植物样品制备的富含半乳糖脂的植物提取物：Gynura divaricata subsp。 菊科（菊科）（GD），小麦（Murdannia bracteata）（C.B.Clarke）J.K.Morton ex D.Y.Hong（Commelinaceae）（MB）和Crassocephalum rabens S.Moore（菊科）（CR）与一系列溶剂。 还提供了用于保护或治疗急性暴发性肝炎，用于保护或治疗败血症或其相关指征的药物，营养或保健组合物和用于皮肤美白的组合物。 这些组合物都包含有效量的富含脂肪体的植物提取物或其纯化的化合物作为生物活性成分。

公开(公告)号：US20200230191A1

公开(公告)日：2020-07-23

申请号：US16585984

申请日：2019-09-27

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen SHYUR ,  Chih-Ting CHANG ,  Yuhsin CHEN

IPC: A61K36/534 ,  A61K31/015 ,  A61K31/122 ,  A61P35/00

Abstract: This disclosure is directed to essential oils, and methods of their use in treating skin conditions. The skin conditions include those involving HRASQ61L mutant keratinocyte activity, wherein the essential oil inhibits said activity to treat and/or prevent skin cancer. Particularly, the present invention denotes to and composition for inhibiting and prevent skin carcinogenesis or BRAF inhibitor, a type of anti-cancer drug induced cutaneous side effect.

公开(公告)号：US20170182001A1

公开(公告)日：2017-06-29

申请号：US15316700

申请日：2015-06-05

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Kuo-Hsiung LEE ,  Kyoko NAKAGAWA-GOTO ,  Jia-Hua FENG ,  Jo-Yu CHEN ,  Wai-Leng LEE ,  Yu-Ting CHENG ,  Jing-Ying HUANG

IPC: A61K31/365 ,  A61K31/655 ,  C07D493/18 ,  A61K31/337 ,  A61K31/437 ,  A61K31/198 ,  A61K45/06

CPC classification number: A61K31/365 ,  A61K31/198 ,  A61K31/337 ,  A61K31/437 ,  A61K31/655 ,  A61K45/06 ,  C07D493/18 ,  A61K2300/00

Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

公开(公告)号：US20140242190A1

公开(公告)日：2014-08-28

申请号：US14269043

申请日：2014-05-02

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Wen-Wan CHAO ,  Ya-Wen CHENG

IPC: A61K31/365 ,  A61K45/06 ,  A61K33/24

CPC classification number: A61K31/365 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/436 ,  A61K31/44 ,  A61K31/454 ,  A61K31/475 ,  A61K31/506 ,  A61K31/56 ,  A61K31/655 ,  A61K31/69 ,  A61K31/704 ,  A61K33/24 ,  A61K36/28 ,  A61K45/06

Abstract: Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analogue thereof; and a pharmaceutically acceptable carrier.

Abstract translation: 公开了在有需要的受试者中预防和/或减少抗癌剂的副作用的方法。 所述方法包括对患有抗癌剂治疗的受试者施用包含治疗有效量的分离的脱氧耳环素和/或其类似物的组合物; 和药学上可接受的载体。