公开(公告)号：US12178870B2

公开(公告)日：2024-12-31

申请号：US18662436

申请日：2024-05-13

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/145 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US11992525B2

公开(公告)日：2024-05-28

申请号：US18501578

申请日：2023-11-03

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61P31/16 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US11918641B2

公开(公告)日：2024-03-05

申请号：US17998208

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/145 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).