公开(公告)号：US11053546B2

公开(公告)日：2021-07-06

申请号：US15737105

申请日：2016-07-13

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Jurgen Peter Lode Del Favero ,  Michaël Vyverman ,  Paul Vauterin

IPC: G16B20/00 ,  G16H50/20 ,  C12Q1/6881 ,  C12Q1/6827 ,  G16H10/40 ,  G01N33/49 ,  G01N33/68

Abstract: A method for estimating whether a female is pregnant, said method comprising measuring allele presences (D) for a plurality of genetic markers of at least one chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (Fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.

公开(公告)号：US11155854B2

公开(公告)日：2021-10-26

申请号：US15737093

申请日：2016-07-13

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Paul Vauterin ,  Michaël Vyverman ,  Joachim De Schrijver

IPC: C12Q1/6879 ,  G16H50/20 ,  C12Q1/6809 ,  G16B20/00 ,  G16H10/40 ,  C12Q1/686 ,  G01N33/68

Abstract: A method for estimating a gender of a foetus of a pregnant female, said method comprising measuring allele presences (DX) for a first plurality of genetic markers of the X-chromosome and allele presences (DR) for a second plurality of genetic markers of at least one reference chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a pregnant female; based on said measured allele presences for said first plurality, determining a first fraction thereof which is associated with purely homozygous genetic markers; based on said measured allele presences for said second plurality, determining a second fraction thereof which is associated with purely homozygous genetic markers; and estimating a gender of said foetus based on said first and second fraction.