YARN FOR CELL CULTURE SCAFFOLD AND FABRIC COMPRISING THE SAME

    公开(公告)号:US20190338233A1

    公开(公告)日:2019-11-07

    申请号:US16309649

    申请日:2017-06-13

    Abstract: Provided is yarn for a cell culture scaffold. The yarn for a cell culture scaffold according to an exemplary embodiment of the present invention includes slitting yarn produced by cutting a compressed nanofiber web to a predetermined width. Accordingly, by creating microenvironments suitable for migration, proliferation and differentiation of cells, cell viability may be enhanced and cells may be three-dimensionally proliferated. In addition, a scaffold according to the present invention has a mechanical strength sufficient for prevention of disruption of the scaffold which occurs during cell culture, such that cells may be stably proliferated. Further, the scaffold according to the present invention uses slitting yarn formed of the compressed nanofiber web, thereby having pores with various sizes, and therefore cell proliferation and cell viability may be enhanced by creation of an extracellular matrix-like environment.

    CELL CULTURE SHEET ASSEMBLY FOR LARGE-CAPACITY INCUBATOR, AND LARGE-CAPACITY INCUBATOR COMPRISING SAME

    公开(公告)号:US20220002651A1

    公开(公告)日:2022-01-06

    申请号:US17293993

    申请日:2019-11-14

    Abstract: Provided is a cell culture sheet for a large-capacity incubator. A cell culture sheet according to one embodiment of the present invention is a cell culture sheet provided in a large-capacity incubator having a plurality of sheets disposed to be spaced apart at predetermined intervals therein, wherein the cell culture sheet has an area of 100 cm2 or more and a bending depth of 0.5 cm or less. As such, even when the culture sheets are closely placed in a limited volume of space, there is little sagging or shape deformation in a specific direction to prevent the occurrence of contact with adjacent culture sheets, thereby preventing a decrease in cell culture volume due to a dead space. Furthermore, since the flow of a cell culture fluid due to the occurrence of contact can be minimized or prevented, a large capacity of cells can be stably and smoothly cultivated such that the cell culture sheet is very suitable for a large-capacity incubator and can be widely applied to the cell culture industry.

    PORTABLE BIOREACTOR
    5.
    发明申请

    公开(公告)号:US20250136909A1

    公开(公告)日:2025-05-01

    申请号:US18692842

    申请日:2022-09-15

    Abstract: A portable bioreactor is provided. The portable bioreactor may comprise: a frame unit; a cell culture unit which has one side mounted to the frame unit and in which a plurality of supports for cell culture are arranged, the cell culture unit being provided with an inlet, through which a medium supplied from the outside flows in, and an outlet, through which the medium inside the cell culture unit is discharged to the outside, a medium adjustment unit installed in the frame unit and storing therein a certain amount of medium for the cell culture; a circulation pump installed and fixed to the frame unit to circulate the medium stored in the medium adjustment unit; and a gas supply unit for supplying gas to the medium adjustment unit to maintain the medium stored in the medium adjustment unit at a constant pH.

    METHOD FOR MANUFACTURING THERMALLY ADHESIVE FIBER WEB AND THERMALLY ADHESIVE FIBER WEB PRODUCED THEREBY

    公开(公告)号:US20250066962A1

    公开(公告)日:2025-02-27

    申请号:US18723318

    申请日:2022-12-22

    Abstract: A thermally adhesive fiber web implemented by including the steps of: (1) preparing respectively a first spinning solution in which a support component and a second spinning solution in which a thermally adhesive component; (2) performing electrospinning such that the first spinning solution is discharged to a portion of the end surface of a discharge port and the second spinning solution is discharged to the remaining portion, thereby accumulating side-by-side type thermally adhesive composite fibers having a diameter of less than 1 μm; and (3) applying heat to the accumulated side-by-side type thermally adhesive composite fibers. The thermally adhesive fiber web enables easy interfacial bonding to a heterogeneous material with a different material and structural specification and prevents pores formed in an initial stage from being closed during thermal bonding.

    BIOREACTOR FOR SUSPENDED CELLS
    7.
    发明申请

    公开(公告)号:US20240409865A1

    公开(公告)日:2024-12-12

    申请号:US18698784

    申请日:2022-09-15

    Abstract: A bioreactor for suspended cells is provided. The bioreactor for suspended cells comprises: a housing which is formed in the shape of a container having a culture space with a predetermined volume, and which comprises pots for seeding; a support assembly comprising a plurality of supports arranged at intervals in multiple stages in one direction of the housing; at least one gas inlet penetrating the housing by a predetermined area; and a porous member for covering the gas inlet, wherein the culture space comprises a medium storage space filled with a predetermined amount of a medium so that all the plurality of supports are submerged therein, and the medium storage space can comprise a plurality of cell growth spaces divided through the plurality of supports arranged at intervals in multiple stages.

    METHOD FOR MANUFACTURING FIBER ASSEMBLY FOR PROVIDING BINDING SURFACE TO BIOSUBSTANCE AND FIBER ASSEMBLY, MANUFACTURED THEREBY, FOR PROVIDING BINDING SURFACE TO BIOSUBSTANCE

    公开(公告)号:US20230080853A1

    公开(公告)日:2023-03-16

    申请号:US17904339

    申请日:2021-02-17

    Abstract: A method for manufacturing a fiber assembly for providing a binding surface to a bio-substance is provided. A fiber assembly for providing a binding surface to a bio-substance according to an embodiment of the present invention is manufactured by a method comprising the steps of: (1) preparing a fiber assembly in which a plurality of fibers is accumulated; and (2) performing modification to provide the fiber surface with a carboxyl group reactive to an amine group present in a bio-substance. According to the method, a bio-substance can be easily introduced at a high content into the fiber assembly. In addition, bio-substances that are conjugated therebetween and adsorbed through physical adsorption, etc. are remarkably reduced in the introduction procedure of bio-substances, whereby bio-substances can be availed with high precision and reliability in applications employing bio-substances. Furthermore, applications employing bio-substances can undergo minimal property variations attributed to the bio-substances as detachment of the bio-substances is minimized or prevented. Accordingly, the bio-substances fixed on the surface of the fiber assembly according to the present invention can find a broad spectrum of applications in various fields including the material engineering, bio engineering, medical fields, and so on.

    CELL CULTURE APPARATUS
    10.
    发明申请

    公开(公告)号:US20220389362A1

    公开(公告)日:2022-12-08

    申请号:US17754995

    申请日:2020-10-12

    Abstract: A cell culture apparatus is provided. A cell culture apparatus according to one exemplary embodiment of the present invention comprises: a cell culture part comprising an accommodation space in which a plurality of supports for cell culture are disposed; a medium supply part for storing a predetermined amount of medium to be supplied to the cell culture part, and maintaining a predetermined carbon dioxide concentration of the medium stored therein by using carbon dioxide introduced from the outside through a gas supply port; and a pump, which interconnects the cell culture part and the medium supply part so as to circulate, in the cell culture part, a medium stored in the medium supply part.

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