公开(公告)号：US10815201B2

公开(公告)日：2020-10-27

申请号：US16851402

申请日：2020-04-17

Applicant: API CORPORATION

Inventor： Naoyuki Watanabe ,  Takanobu Iura ,  Hideki Oomiya ,  Masaki Nagahama

IPC: A61P43/00 ,  A61P3/06 ,  A61K31/47 ,  C07D215/14 ,  C07B61/00 ,  C12P17/12

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

公开(公告)号：US12091390B2

公开(公告)日：2024-09-17

申请号：US16442770

申请日：2019-06-17

Applicant: API CORPORATION

Inventor： Naoyuki Watanabe ,  Tomoko Maeda ,  Yasumasa Dekishima ,  Hiroshi Kawabata ,  Masaki Nagahama

IPC: C12N9/00 ,  C07D239/42 ,  C12N9/04 ,  C12P17/12

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12 ,  C12Y101/01184

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

公开(公告)号：US10676441B2

公开(公告)日：2020-06-09

申请号：US15749377

申请日：2016-08-05

Applicant: API CORPORATION

Inventor： Naoyuki Watanabe ,  Takanobu Iura ,  Hideki Oomiya ,  Masaki Nagahama

IPC: A61K31/47 ,  C12P17/12 ,  C07B61/00 ,  C07D215/14

Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.

公开(公告)号：US10377722B2

公开(公告)日：2019-08-13

申请号：US15600196

申请日：2017-05-19

Applicant: API CORPORATION

Inventor： Naoyuki Watanabe ,  Tomoko Maeda ,  Yasumasa Dekishima ,  Hiroshi Kawabata ,  Masaki Nagahama ,  Kosuke Ito

IPC: C12P7/42 ,  C12N9/02 ,  C12N9/04 ,  C07D239/42 ,  C12P17/12

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

公开(公告)号：US09695130B2

公开(公告)日：2017-07-04

申请号：US15116861

申请日：2015-02-06

Applicant: API CORPORATION

Inventor： Naoyuki Watanabe ,  Masaki Nagahama ,  Takashi Ohtani

IPC: C07D239/42 ,  C12P17/12 ,  C12N9/04

CPC classification number: C07D239/42 ,  C12N9/0006 ,  C12P17/12

Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.