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公开(公告)号：US10815201B2
公开(公告)日：2020-10-27
申请号：US16851402
申请日：2020-04-17
Applicant: API CORPORATION
Inventor： Naoyuki Watanabe , Takanobu Iura , Hideki Oomiya , Masaki Nagahama
Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
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公开(公告)号：US11572551B2
公开(公告)日：2023-02-07
申请号：US17043339
申请日：2019-03-29
Applicant: API CORPORATION
Inventor： Toyokazu Yoshida , Koichi Ishida , Ryoma Miyake , Takanobu Iura , Hiroshi Kawabata
Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.
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公开(公告)号：US10676441B2
公开(公告)日：2020-06-09
申请号：US15749377
申请日：2016-08-05
Applicant: API CORPORATION
Inventor： Naoyuki Watanabe , Takanobu Iura , Hideki Oomiya , Masaki Nagahama
IPC: A61K31/47 , C12P17/12 , C07B61/00 , C07D215/14
Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
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