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    Device and method for thermal cycling
    2.
    发明授权
    Device and method for thermal cycling 有权

    公开(公告)号：US09889448B2

    公开(公告)日：2018-02-13

    申请号：US14635506

    申请日：2015-03-02

    Applicant: APPLIED BIOSYSTEMS, LLC

    Inventor： Donald R. Sandell

    IPC: B01L7/00 ,  B01L9/00 ,  C12Q1/68

    CPC classification number: B01L7/52 ,  B01L9/523 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  C12Q1/686

    Abstract: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block assembly is adapted for movement between a first position permitting the translation of the sample well tray into alignment with sample block assembly, and a second position, upward relative to the first position, where the sample block assembly contacts the sample well tray. A method of performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray in a thermal cycling device is also provided.

    Apparatus and Method for Transporting Sample Well Trays
    3.
    发明申请
    Apparatus and Method for Transporting Sample Well Trays 审中-公开
    用于运输样品井盘的装置和方法

    公开(公告)号：US20160266159A1

    公开(公告)日：2016-09-15

    申请号：US15162393

    申请日：2016-05-23

    Applicant: APPLIED BIOSYSTEMS, LLC

    Inventor： Jessica E. Barzilai ,  Donald R. Sandell

    IPC: G01N35/02 ,  B01L9/00 ,  B01L7/00

    CPC classification number: G01N35/028 ,  B01L7/52 ,  B01L9/523 ,  B01L2300/06 ,  B01L2300/0829 ,  G01N35/04 ,  G01N2035/042 ,  Y10T436/11

    Abstract: An apparatus for transporting sample well trays with respect to a heating device is provided. The apparatus includes a sample well tray holder, a rotational actuator, and a biasing mechanism. The sample well tray holder includes a plate in which a sample well tray may be positioned. The sample well tray holder is configured to rotate about a first rotational axis. The rotational actuator is configured to rotate the sample well tray holder about the first rotational axis. The biasing mechanism is configured to urge the sample well tray holder in a generally upward direction along the first rotational axis.

    Abstract translation: 提供了一种用于相对于加热装置输送样品阱盘的装置。 该装置包括样品井盘托架，旋转致动器和偏置机构。 样品孔盘托架包括其中可以定位样品井托盘的板。 样品井盘托架被构造成围绕第一旋转轴线旋转。 旋转致动器被配置为围绕第一旋转轴线旋转样品阱盘托架。 偏压机构构造成沿着第一旋转轴线沿大致向上的方向推动样品井托盘保持器。

    Device and method for Thermal Cycling
    4.
    发明申请
    Device and method for Thermal Cycling 有权
    热循环的装置和方法

    公开(公告)号：US20150165439A1

    公开(公告)日：2015-06-18

    申请号：US14635506

    申请日：2015-03-02

    Applicant: APPLIED BIOSYSTEMS, LLC

    Inventor： Donald R. Sandell

    IPC: B01L7/00 ,  C12Q1/68

    CPC classification number: B01L7/52 ,  B01L9/523 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  C12Q1/686

    Abstract: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block assembly is adapted for movement between a first position permitting the translation of the sample well tray into alignment with sample block assembly, and a second position, upward relative to the first position, where the sample block assembly contacts the sample well tray. A method of performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray in a thermal cycling device is also provided.

    Abstract translation: 一种热循环装置，用于对位于样品井托盘中的多个生物样品进行核酸扩增。 热循环装置包括样品块组件，光学检测系统和构造成保持样品井托盘的样品孔盘托架。 样品块组件适于在允许样品井盘的平移与样品块组件对准的第一位置和相对于第一位置向上的第二位置之间移动，其中样品块组件接触样品井盘。 还提供了对位于热循环装置中的样品阱托盘中的多个生物样品进行核酸扩增的方法。

    Sample Chamber Array and Method for Processing a Biological Sample
    5.
    发明申请
    Sample Chamber Array and Method for Processing a Biological Sample 审中-公开
    样品室阵列和处理生物样品的方法

    公开(公告)号：US20140242593A1

    公开(公告)日：2014-08-28

    申请号：US14170060

    申请日：2014-01-31

    Applicant: Applied Biosystems, LLC

    Inventor： Donald R. Sandell

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/505 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/0812 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/049 ,  B01L2400/0655 ,  G01N35/00009 ,  Y10T156/10

    Abstract: A sample chamber array is provided. The sample chamber array may comprise at least one reservoir in fluid communication with at least one sample chamber, and a movable portion defining the sample chamber. The reservoir is fillable with a liquid biological sample. The movable portion may be movable with respect to the remainder of the sample chamber from a first position to a second position. In the first position the movable portion is concave and the sample chamber is without biological sample. In the second position the movable portion is convex and the sample chamber comprises biological sample. The movement of the movable portion to the second position causes a pressure drop to transport the biological sample into the sample chamber from the at least one reservoir. Methods for processing a biological sample and methods of making a sample chamber array are also provided.

    Abstract translation: 提供样品室阵列。 样品室阵列可以包括与至少一个样品室流体连通的至少一个储存器和限定样品室的可移动部分。 储存器可用液体生物样品填充。 可移动部分可以相对于样品室的其余部分从第一位置移动到第二位置。 在第一位置，可移动部分是凹的，样品室没有生物样品。 在第二位置，可移动部分是凸的，并且样品室包括生物样品。 可移动部分到第二位置的运动导致压力下降，以将生物样品从至少一个储存器输送到样品室中。 还提供了处理生物样品的方法和制备样品室阵列的方法。

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