公开(公告)号：US20230187026A1

公开(公告)日：2023-06-15

申请号：US17924079

申请日：2021-05-10

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Karen Anderson ,  Abhishek Singharoy ,  Eric Wilson

IPC: G16B35/20 ,  G16B40/10 ,  G16B20/00

CPC classification number: G16B35/20 ,  G16B40/10 ,  G16B20/00

Abstract: A consensus MHC-I binding and processing prediction workflow, methods and systems are described, for improving T-cell immunity against threats such as viruses and cancer. The methods and systems can also be used to determine population fitness against a target antigen such as a pathogen or cancer.

公开(公告)号：US11525831B2

公开(公告)日：2022-12-13

申请号：US16743906

申请日：2020-01-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/564 ,  G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  C12N15/11

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US11243208B2

公开(公告)日：2022-02-08

申请号：US16317184

申请日：2017-07-11

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Benjamin Katchman ,  Karen Anderson ,  Garrick Wallstrom ,  Joshua LaBaer ,  Daniel Cramer

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/574

Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.

公开(公告)号：US11208640B2

公开(公告)日：2021-12-28

申请号：US16632782

申请日：2018-04-27

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Radwa Ewaisha ,  Samira Kiani ,  Shayesteh Roshdi Ferdosi ,  Karen Anderson ,  Farzaneh Moghadam ,  Sri Krishna ,  Mo Reza Ebrahimkhani

IPC: C12N9/22 ,  G01N33/573 ,  A61K48/00

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

公开(公告)号：US20190302122A1

公开(公告)日：2019-10-03

申请号：US16317184

申请日：2017-07-11

Applicant: Benjamin KATCHMAN ,  Karen ANDERSON ,  Garrick WALLSTROM ,  Joshua LABAER ,  Daniel CRAMER ,  ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Benjamin Katchman ,  Karen Anderson ,  Garrick Wallstrom ,  Joshua LaBaer ,  Daniel Cramer

IPC: G01N33/574

Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.

公开(公告)号：US20170363631A1

公开(公告)日：2017-12-21

申请号：US15534203

申请日：2015-12-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL INSTITUTES OF HEALTH

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/574 ,  C12Q1/68 ,  C07K16/30 ,  C12N15/11

CPC classification number: G01N33/57415 ,  C07K16/3015 ,  C12N15/11 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/564

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20170059563A1

公开(公告)日：2017-03-02

申请号：US15308330

申请日：2015-05-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Jennifer Blain Christen ,  Karen Anderson ,  Benjamin Katchman

IPC: G01N33/543 ,  G01N21/64 ,  A61B5/00 ,  B01L3/00

CPC classification number: G01N33/54366 ,  A61B5/0071 ,  A61B5/6802 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/123 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/0221

Abstract: A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.

Abstract translation: 公开了一种完全集成的小型化光学生物传感器及其制造方法。 生物传感器可以包括流体输送系统和光学系统。

公开(公告)号：US12084691B2

公开(公告)日：2024-09-10

申请号：US17546810

申请日：2021-12-09

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Radwa Ewaisha ,  Samira Kiani ,  Shayesteh Roshdi Ferdosi ,  Karen Anderson ,  Farzaneh Moghadam ,  Sri Krishna ,  Mo Reza Ebrahimkhani

IPC: C12N9/22 ,  A61K48/00 ,  G01N33/573

CPC classification number: C12N9/22 ,  G01N33/573 ,  A61K48/00 ,  C12N2310/20 ,  C12N2800/80 ,  G01N2333/922

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

公开(公告)号：US11524063B2

公开(公告)日：2022-12-13

申请号：US16762085

申请日：2018-11-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  BAYLOR COLLEGE OF MEDICINE

Inventor： Sri Krishna ,  Marshall Posner ,  Andrew Sikora ,  Karen Anderson

IPC: A61K39/12 ,  A61P31/20 ,  A61P35/00 ,  A61K39/00

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

公开(公告)号：US20220162574A1

公开(公告)日：2022-05-26

申请号：US17546810

申请日：2021-12-09

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Samira Kiani ,  Radwa Ewaisha ,  Shayesteh Roshdi Ferdosi ,  Karen Anderson ,  Farzaneh Moghadam ,  Sri Krishna ,  Mohammad R Ebrahimkhani

IPC: C12N9/22 ,  G01N33/573

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.