公开(公告)号：US20170045515A1

公开(公告)日：2017-02-16

申请号：US15307112

申请日：2015-03-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Karen Anderson ,  Marshall Posner ,  Joshua LaBaer

IPC: G01N33/569 ,  G01N33/574

CPC classification number: G01N33/56983 ,  G01N33/57411 ,  G01N2333/025 ,  G01N2469/20

Abstract: Provided herein are methods for the rapid detection of HPV types, such as HPV 16- and HPV18-specific antibodies, in patient samples that contain antibodies. For example, patients with head and neck cancers have detectable antibodies to multiple early genes derived from HPV. These antibodies also are useful as biomarkers for HPV-associated malignancies and premalignant states, for diagnosis and prognosis, and for methods of assessing treatment and cancer-recurrence prediction.

Abstract translation: 本文提供了用于在含有抗体的患者样品中快速检测HPV类型（例如HPV16-和HPV18-特异性抗体）的方法。 例如，患有头颈部癌症的患者对来自HPV的多个早期基因具有可检测的抗体。 这些抗体还可用作HPV相关恶性肿瘤和恶化前状态的生物标志物，用于诊断和预后，以及评估治疗和癌症复发预测的方法。

公开(公告)号：US11524063B2

公开(公告)日：2022-12-13

申请号：US16762085

申请日：2018-11-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  BAYLOR COLLEGE OF MEDICINE

Inventor： Sri Krishna ,  Marshall Posner ,  Andrew Sikora ,  Karen Anderson

IPC: A61K39/12 ,  A61P31/20 ,  A61P35/00 ,  A61K39/00

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.