公开(公告)号：US20240280495A1

公开(公告)日：2024-08-22

申请号：US18568555

申请日：2022-06-06

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES ,  ARYBALLE

Inventor： Loic LAPLATINE ,  Cyril HERRIER ,  Thierry LIVACHE

IPC: G01N21/77 ,  G01N21/25

CPC classification number: G01N21/7703 ,  G01N21/253 ,  G01N2021/7779

Abstract: An interferometric system for detecting analytes present in a fluid sample, including: an array of Mach-Zehnder interferometers arranged periodically and rectangularly whose arms extend in a spiral and/or serpentine fashion with an aspect ratio equal to 1; and an array of sensitive surfaces each formed of receptors with which the analytes are able to interact by adsorption/desorption and arranged periodically and hexagonally.

公开(公告)号：US20250110128A1

公开(公告)日：2025-04-03

申请号：US18727911

申请日：2023-01-11

Applicant: ARYBALLE ,  COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE GRENOBLE ALPES

Inventor： Cristina-Cassiana ANDREI ,  Cyril HERRIER ,  Sami SLIMANI ,  Yanxia HOU-BROUTIN ,  Christophe MOREAU ,  Thierry LIVACHE

IPC: G01N33/569 ,  G01N21/552

Abstract: A method for detecting biological objects by means of an SPR imaging detection system comprising an optical measurement device configured to generate plasmon resonance on a functionalized surface when said surface is exposed to a gas; the method comprising: an assimilation step by exposing the functionalized surface to a sample of interest formed of an aqueous carrier liquid containing the biological objects; a step of removing the liquid in contact with the functionalized surface and exposing the surface to a gas not containing the biological objects, said objects remaining bound to the ligands of the sensitive site of the functionalized surface; a step of acquiring an image of the sensitive site; a step of detecting the biological objects from the acquired image.

公开(公告)号：US20220252564A1

公开(公告)日：2022-08-11

申请号：US17626097

申请日：2020-07-08

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES ,  ARYBALLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Yanxia Hou-Broutin ,  Sophie BRENET ,  Arnaud BUHOT ,  Thierry LIVACHE ,  Cyril HERRIER ,  Tristan ROUSSELLE

IPC: G01N33/00

Abstract: A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an α-amino acid. The α-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the α-amino acid of the receptor of another sensor of the first series is hydrophobic, and the α-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.

公开(公告)号：US20200088702A1

公开(公告)日：2020-03-19

申请号：US16490527

申请日：2018-03-02

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE GRENOBLE ALPES ,  ARYBALLE TECHNOLOGIES

Inventor： Cyril HERRIER ,  Yanxia HOU-BROUTIN ,  Francois-Xavier GALLAT ,  Thierry LIVACHE ,  Tristan ROUSSELLE

IPC: G01N33/00 ,  G01N21/61 ,  G01N21/552 ,  G01N21/41

Abstract: The invention relates to a method for calibrating an electronic nose, said electronic nose comprising a plurality of optical sensors arranged on a surface and capable of being in contact with a gaseous medium of interest, said optical sensors being capable of delivering a signal representative of the local optical index of the gaseous medium of interest when they are excited by photons, the method being characterized in that it comprises the following steps: after having placed the electronic nose in a gaseous medium of interest at the initial pressure (P0) and the initial temperature (T0): a) sending photons in the direction of the sensors so as to excite said sensors; b) measuring the signal delivered by each of the sensors, this measurement providing as many responses as there are sensors; c) modifying the pressure and/or temperature of the gaseous medium of interest; d) repeating step b); and e) for each sensor, determining a correction factor such as a variation in the signal between steps d) and b) corrected by the correction factor either equal to or substantially equal to a variation in the signal between these same steps for a reference, said reference being provided by a reference sensor or a combination of reference sensors. Such a method allows a physical calibration, that in the present case is relative, to be performed between the different sensors.

公开(公告)号：US20230012059A1

公开(公告)日：2023-01-12

申请号：US17757533

申请日：2020-12-15

Applicant: ARYBALLE

Inventor： Romain DUBREUIL ,  Cyril HERRIER ,  Thierry LIVACHE ,  Johanna DECORPS ,  Yann GUEGANNO

IPC: G01N33/00 ,  C11B9/00 ,  G16C60/00 ,  G16C20/70

Abstract: The present invention relates to a method for characterising, by means of an electronic nose, the release kinetics of odorous compounds from a sample, comprising the following series of steps: (a) supplying a sample; (b) at a time t1, exposing the sensor array of the electronic nose to some of the gaseous medium comprising the odorous compounds released from the sample, and processing the response emitted by the sensor array of the electronic nose, after said exposure, in the form of a signal; and (c) repeating step (b) at least once, at a time t2 different from the time t1, whereby an olfactory kinetic signature characterising the sample is obtained. The present invention also relates to the use of this method for anti-counterfeiting and/or quality control purposes and for generating a data bank or database of temporal olfactory signatures. The present invention finally relates to certain devices used when implementing such methods.

公开(公告)号：US20220187263A1

公开(公告)日：2022-06-16

申请号：US17442201

申请日：2020-03-25

Applicant: ARYBALLE TECHNOLOGIES

Inventor： Thierry LIVACHE ,  Cyril HERRIER ,  Romain DUBREUIL

IPC: G01N33/00

Abstract: A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose.

公开(公告)号：US20200256793A1

公开(公告)日：2020-08-13

申请号：US16647414

申请日：2018-09-11

Applicant: ARYBALLE TECHNOLOGIES ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  UNIVERSITÉ GRENOBLE ALPES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Yanxia HOU-BROUTIN ,  Sophie BRENET ,  Thierry LIVACHE ,  Cyril HERRIER ,  Tristan ROUSSELLE

IPC: G01N21/552 ,  G01N21/77 ,  G01N33/00

Abstract: The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, which detection system comprises a plurality of cross-reactivity detection sensors (D1, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that it further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. It further relates to an electronic nose comprising such a detection system.